Primary Renal Lymphoma: A Rare Neoplasm That May Present as a Primary Renal Mass

Ahmad, Asad Hayat; MacLennan, Gregory T.; Listinsky, Catherine M.

doi:10.1097/01.ju.0000148570.46368.c0

Cited by 34 publications

(18 citation statements)

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“…PRL is often present on only one side of the kidney in adult patients, whereas it can be bilateral in pediatric patients (6,7). PRL lacks clear clinical manifestations and appears to be similar to renal cell carcinoma (RCC), renal abscess and other kidney tumor metastases.…”

Section: Introductionmentioning

confidence: 99%

Primary renal lymphoma: A case report and literature review

Chen

Fang

et al. 2016

Oncology Letters

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Abstract. Primary renal lymphoma (PRL) is a rare disease, with no more than 70 cases reported in the literature. The present study reports the case of a 70-year-old woman with PRL. The patient was asymptomatic, however, a mass on the right kidney was identified incidentally during routine physical examination. Computed tomography revealed a mass in the right kidney that was 3.6 cm in diameter. Subsequently, right nephrectomy was performed. The histological evaluation of the nephrectomy specimen showed diffuse large B-cell non-Hodgkin's lymphoma. The patient was treated with 6-8 cycles of a cyclophosphamide, epirubicin, vindesine and dexamethasone regimen. Follow-up examination performed after 2 months of treatment revealed no evidence of local recurrence. The present study also reviewed 49 cases of PRL that have been reported since 1989. It was found that a shorter survival time was experienced by patients with bilateral PRL (mean, 21 months) compared with unilateral PRL (mean, 68 months). A shorter survival time was also experienced by patients who were treated with chemotherapy only (mean, 15.8 months) compared with those who were treated with combination chemotherapy and surgery (mean, 49.4 months).

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Section: Introductionmentioning

confidence: 99%

Primary renal lymphoma: A case report and literature review

Chen

Fang

et al. 2016

Oncology Letters

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“…[1][2][3][4][5][6][7][8][9][10][11][12] Furthermore, primary renal lymphoma, accounting for 0.1-0.7% of extranodal lymphomas, can also be a very rare cause of ARF. [13][14][15][16][17][18][19] To date, approximately 150 glomerulonephropathy cases have been reported among all cases with Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (non-HL), and 6.8% of them were reported as membranous glomerulonephritis (MGN). This rate is about 5% in HL cases, and only 5 MGN cases have been reported to date.…”

Section: Introductionmentioning

confidence: 99%

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

et al. 2011

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Although acute renal failure developing due to malignancies is a frequent condition, malignant renal infiltration is rarely observed among these causes. Among all malignant diseases, the hematolymphoid malignancies are the most prone to renal infiltration. Other types involved in cases with lymphoma are glomerulopathies, including immune-complex glomerular diseases such as minimal change disease, membranous glomerulonephritis, membranoproliferative glomerulonephritis, and focal segmental glomerulosclerosis. We present herein the rare case of a 22-year-old male with both membranous glomerulonephritis and CD20 (+) lymphoid infiltration related to Hodgkin's lymphoma in the renal interstitial tissue, as detected on biopsy. The patient was treated with adriamycin, bleomycin, vinblastine, and dacarbazine protocol after pulse corticosteroid treatment, and a dramatic improvement in renal function was observed after 2 days of treatment. In this article, an exceptional renal involvement of Hodgkin's lymphoma is discussed in light of the related literature.

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“…Kidney involvement is mostly secondary to a lymphoma nearby or more distant, due to hematogeneous dissemination [1,3]. Primary lymphomas of the kidney develop in the parenchyma, resulting in the production of a renal mass [1,9], which sometimes extends preferentially into the hilum. In one of the most recent reviews of the literature [10], 60 cases were accepted as being primary renal lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Marginal zone lymphoma of both spleen and kidney displaying transformation into large B-cell lymphoma

et al. 2006

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We report a case of simultaneous involvement of the spleen and the left kidney in a marginal zone lymphoma with a monotypic lymphoplasmacytic cell component, which transformed into a diffuse large B-cell lymphoma of the immunoblastic type. PCR showed that the small and large B-cell populations carried the same type of immunoglobulin heavy chain gene rearrangement. This type of rearrangement was detected in the spleen, the latero-aortic lymphadenopathy and the kidney demonstrating that it is the same lymphoma that affected both organs and the lymph nodes. Primary renal lymphoma is very rare and only a few cases of renal marginal zone lymphoma, MALT type, have been reported. Involvement of simultaneous multiple sites has been described in MALT type lymphoma, but splenic involvement secondary to renal MALT lymphoma seems to have never been observed. Nevertheless, in our case the huge size of the spleen associated with splenic hilar node involvement is consistent with primary splenic marginal zone lymphoma. The extension into latero-aortic lymph nodes of this lymphoma can explain secondary kidney involvement. The nodal Kaposi's sarcoma observed in this patient of Mediterranean origin was probably coincidental.

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Primary Renal Lymphoma: A Rare Neoplasm That May Present as a Primary Renal Mass

Cited by 34 publications

References 0 publications

Primary renal lymphoma: A case report and literature review

Primary renal lymphoma: A case report and literature review

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

Marginal zone lymphoma of both spleen and kidney displaying transformation into large B-cell lymphoma

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