Primary renal lymphoma: an unusual finding following radical nephrectomy

Rissman, Cody M.; Dagrosa, Lawrence; Pettus, Jason R.; Dillon, Jessica L.; Sverrisson, Einar F.

doi:10.5414/cncs108955

Cited by 14 publications

(15 citation statements)

References 7 publications

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“…Chronic inflammation invades lymphoid cells which undergo oncogenic transformation in situ . Reports of PRL arising in patients with chronic pyelonephritis support this theory ; however, PRL is known to occur in patients without any primary kidney disease . Association of PRL with other chronic inflammatory and infectious diseases such as Sjogren's disease, systemic lupus erythematosus, and Epstein‐Barr virus infections has also been reported .…”

Section: Introductionmentioning

confidence: 99%

“…3,12 Reports of PRL arising in patients with chronic pyelonephritis support this theory 3 ; however, PRL is known to occur in patients without any primary kidney disease. 7 Association of PRL with other chronic inflammatory and infectious diseases such as Sjogren's disease, systemic lupus erythematosus, and Epstein-Barr virus infections has also been reported. 3 Another theory states that PRL originates in the lymphatics surrounding the renal capsule and progress to infiltrate the kidney manifesting as solitary or multiple focal masses, large infiltrations in unilateral kidney or diffuse bilateral infiltrations.…”

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confidence: 99%

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Primary renal lymphoma: A population‐based analysis using the SEER program (1973‐2015)

Taneja

Kumar

Chandra

2020

European J of Haematology

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Objective Primary renal lymphoma (PRL) is defined as a non‐Hodgkin lymphoma (NHL) restricted to kidneys without extensive nodal disease. The literature on epidemiology and outcome in PRL is limited to case reports and small case series. Methods We utilized Surveillance, Epidemiology, and End Result database (1984‐2015) to study the demographic, clinical, and pathological characteristics of PRL. We conducted analysis to assess factors associated with overall survival (OS) and cause‐specific survival (CSS). Results A total of 599 (0.17% of all NHL) patients were eligible for the study. The age‐adjusted incidence was 0.035/100,000 population and is increasing. The median age was 72 years, and most of the patients were Caucasians and were males. Most of the patients had unilateral tumors, and diffuse large B‐cell lymphoma (DLBCL) was the most common histologic type. The median OS was 112 months, while median CSS was not reached. Age ≥ 60 years was the strongest independent risk factor for worse OS and CSS, while non‐DLBCL histology was associated with better OS and CSS. Discussion Primary renal lymphoma is a rare lymphoma with increasing incidence in more recent years. In this study, we describe demographic, clinical, and pathological characteristics of PRL and factors affecting survival among these patients.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Primary renal lymphoma: A population‐based analysis using the SEER program (1973‐2015)

Taneja

Kumar

Chandra

2020

European J of Haematology

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“…We thoroughly reviewed all 54 cases of PRL reported in the literature since 2002 (Table 1). 4,7–49 DLBCL was found to be the most common pathological type, and more male than female patients (64.8%) were reported. Additionally, PRL was generally located in the bilateral kidneys in younger patients (<30 years old) and in a unilateral kidney in older patients, indicating that the site of PRL is age-related.…”

Section: Discussionmentioning

confidence: 99%

Enormous primary renal diffuse large B-cell lymphoma: A case report and literature review

Huang

et al. 2019

J Int Med Res

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Introduction Primary renal lymphoma is a rare malignant lymphoma that is difficult to differentiate from renal cell carcinoma. Positron emission tomography/computed tomography and image-guided percutaneous biopsy are valuable tools for diagnosis. Case report A 64-year-old woman presented with a 2-year history of repeated right waist pain and a 1-month history of nausea, vomiting, and frequent and urgent urination. A computed tomography scan showed a huge mass that was initially considered to be renal cell carcinoma at the upper pole of the right kidney. The mass had invaded the renal pelvis, narrowed the right renal artery, and constricted the inferior vena cava and liver. Postoperative examination of the tumor confirmed lymphoma. We herein present this case and its multidisciplinary team management. Conclusion Multidisciplinary team management is efficient for preoperative assessment and surgery in difficult and high-risk cases. Based on our literature review, we suggest biopsy before chemotherapy whenever possible. Chemotherapy can be implemented after surgery for better survival outcomes.

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“…Lacking in specific symptoms and laboratory indexes makes PRL difficult to diagnose before surgery. [ 21 , 22 ] To date, the diagnostic criteria of PRL made by Stallone in 2000 are still widely used, [ 1 ] the criteria are as follows: lymphomatous renal infiltration, nonobstructive uni- or bilateral kidney enlargement, and no extra localization at diagnosis. The patient in our case fulfilled all 3 criteria.…”

Section: Discussionmentioning

confidence: 99%

Concomitant occurrence of primary renal non-Hodgkin lymphoma and a colon cancer

Li¹,

Zou²,

Wang

et al. 2019

Medicine

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Rationale:Primary renal lymphoma (PRL) is a rare malignancy due to the absence of lymphatic tissues in the kidney, and patients with PRL have been reported to have a poor prognosis due to its rapid invasiveness and limited treatment strategies. Colon cancer is the third most common cancer, and has a high mortality rate. Both malignant diseases predominantly affected elderly men; however, a case with concomitant occurrence of the 2 cancers is extremely rare.Patient concerns:A 78-year-old male patient with abdominal pain came to our hospital. Computed tomography (CT) indicated malignant masses in the left kidney, left adrenal gland, and the lower part of the descending colon.Diagnoses:PRL and colon cancer were diagnosed based on pathological examinations.Interventions:The patient was treated with laparoscopic radical nephrectomy and laparoscopic radical resection of colon cancer.Outcomes:The patient was then transferred to the intensive care unit (ICU) because of poor condition after surgery. He died 3 months after discharge without receiving any other treatment.Lessons:It is worth thinking about whether surgery was reasonable for elderly patients with double malignancies, or palliative treatment to improve the quality of life was more meaningful. This case also contributes to the understanding of the 2 malignancies and highlights the need to pay more attention to patients with multiple primary malignant neoplasms (MPMNs), explore genetic features, and investigate treatments with more survival benefits.

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Primary renal lymphoma: an unusual finding following radical nephrectomy

Cited by 14 publications

References 7 publications

Primary renal lymphoma: A population‐based analysis using the SEER program (1973‐2015)

Primary renal lymphoma: A population‐based analysis using the SEER program (1973‐2015)

Enormous primary renal diffuse large B-cell lymphoma: A case report and literature review

Concomitant occurrence of primary renal non-Hodgkin lymphoma and a colon cancer

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