Primary Renal Neoplasia of Dogs

Abstract

Primary renal tumors in dogs are generally highly malignant with surgery being the only treatment that improves survival.

Marked serum GGT elevations in two dogs with renal carcinoma

“…Of five dogs (our two cases plus those reported by Lee et al 2005, Kye et al 2011, Whitehead et al 2012 with RC and markedly elevated GGT (>100 U/L), two died the day following surgery, and the remaining three lived three, six and 11 months. This contrasts with a reported median survival of 16 months in 49 dogs with RC (Bryan et al 2006 ).…”

The use of contrast‐enhanced ultrasonography for the detection of active renal hemorrhage in a dog with spontaneous kidney rupture resulting in hemoperitoneum

“…Splenic, hepatic, and adrenal masses have been associated with nontraumatic hemoperitoneum in the dog, 2,3 with the spleen reported as the most common source of hemorrhage; however, any mass of the kidney could outgrow its blood supply and result in hemorrhage. [33][34][35] In this case, culture of hemorrhagic fluid was not performed during the initial diagnostic work up because of logistic concerns, while PCR was attempted at a later date 10 because the final histological diagnosis of nematode larvae was unexpected. The absence of DNA amplification by PCR might have been due to DNA deterioration after paraffin embedding of the specimens.…”

Urinary Tract

“…Primary renal tumors are rare in dogs and cats (Bryan et al, 2006;Henry et al, 1999). Tumors can arise from epithelial tissue, mesenchymal tissue, or embryonal tissue of mixed origin.…”

“…Several paraneoplastic syndromes, including polycythemia, leukocytosis, hypertrophic osteopathy, and hypercalcemia, have been described secondary to renal tumors (Chiang et al, 2007;Durno et al, 2011;Gajanayake et al, 2010;Johnson and Lenz, 2011;Petterino et al, 2011;Peeters et al, 2001). Most primary renal tumors in both dogs and cats consist of malignant epithelial tumors (renal cell carcinomas, transitional cell carcinomas [TCCs], and adenocarcinomas) (Bryan et al, 2006;Gil da Costa et al, 2011;Henry et al, 1999;Ramos-Vara et al, 2003). Other tumors include fibromas, sarcomas-including hemangiosarcoma, fibrosarcoma, leiomyosarcoma (Sato et al, 2003), and osteosarcoma-and nephroblastoma.…”