Primary renal osteosarcoma: A case report and review of literature

Namdari, Farshad; Pour, Mohammad Javad Nazar; Behzadi, Arya; Akbari, Mona; Moradi, Hedieh; Dialameh, Hossein

doi:10.1002/ccr3.5957

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Most of the regimens prescribed in the reports are ifosfamide and cisplatin based. 7 , 8 , 12 Fan et al 6 suggested treating ESOS like soft tissue sarcomas with the same chemotherapy regimen because they have similar behavior and prognostic factors. As we know, there are significant data limitations in applying this idea to the treatment of renal ESOS.…”

Section: Discussionmentioning

confidence: 99%

A staghorn kidney stone or extraskeletal osteosarcoma of the kidney? A case report and literature review

et al. 2023

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Extraskeletal osteosarcoma (ESOS) is a very rare entity among renal malignancies. There are few reports of renal ESOS in the database. Renal ESOS was found to have a high rate of local recurrence and distant metastasis. In most reports, the overall survival of patients was less than 1 year. We present a 51-year-old man who presented with gross hematuria and a clinical diagnosis of a staghorn stone in the left kidney. He underwent radical nephrectomy. The pathologic diagnosis of osteosarcoma was evident.

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Section: Discussionmentioning

confidence: 99%

A staghorn kidney stone or extraskeletal osteosarcoma of the kidney? A case report and literature review

et al. 2023

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“…Fewer than 30 cases have been reported so far. [ 1 , 2 ] It accounts for less than 4% of osteosarcomas and less than 1% of soft tissue sarcomas. [ 3 ] The condition can manifest in individuals aged 29 to 82 years.…”

Section: Introductionmentioning

confidence: 99%

Case report: A case of primary renal osteosarcoma

Su,

Fu,

Mao

2024

Medicine

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Rationale: Primary renal osteosarcoma is an exceedingly rare malignant tumor. Fewer than 30 cases have been reported in the literature since 1936. Furthermore, it has a high risk of metastasis and a poor overall prognosis rate. Patient’s concerns: In this report, we present a case of osteosarcoma originating from the left kidney (21 cm × 18 cm × 11 cm) with adhesions of the descending colon mesentery and the abdominal wall. A 63-year-old male patient presented with flank pain and gross hematuria. Diagnoses: A computed tomography scan revealed that the lesion with irregular margins was observed at the lower pole of the left kidney. Enhanced CT scan showed significant inhomogeneous enhancement of the lesion, with non-enhancing necrotic areas. A radical nephrectomy was performed. The immunohistochemistry results support the diagnosis of osteosarcoma. Interventions: Postoperatively, the patient participated in clinical trials and received treatment with a PD-1 antibody (2 weeks/once). Outcomes: At the one-year follow-up, the patient reported late-stage systemic cancer-related pain, necessitating daily pain relief medication. Unfortunately, the patient passed away 18 months after the surgery. Lessons: The case reported here is an exceedingly rare malignant osteosarcoma that originated from the kidney with the invasion of the descending colon mesentery and the abdominal wall. The patient received treatment with a PD-1 antibody (2 weeks/once). However, the patient passed away 18 months after the surgery. With the application of genetic testing technology and advancements in molecular biology, it was expected that specific targeted therapies for this condition would emerge in the future.

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“…Generally, patients will not go to the hospital for examination until they have symptoms, such as physical weakness and gross hematuria [ 15 ]. However, when kidney cancer has such symptoms, patients are basically in the advanced stage of cancer, which significantly increases the difficulty of treatment and results in a lower survival rate [ 16 ]. Therefore, simple and efficient means of early cancer screening can effectively assist in cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

A Novel, Simple, and Low-Cost Approach for Machine Learning Screening of Kidney Cancer: An Eight-Indicator Blood Test Panel with Predictive Value for Early Diagnosis

Wang

Huang

2022

Current Oncology

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Clear cell renal cell carcinoma (ccRCC) accounts for more than 90% of all renal cancers. The five-year survival rate of early-stage (TNM 1) ccRCC reaches 96%, while the advanced-stage (TNM 4) is only 23%. Therefore, early screening of patients with renal cancer is essential for the treatment of renal cancer and the long-term survival of patients. In this study, blood samples of patients were collected and a pre-defined set of blood indicators were measured. A random forest (RF) model was established to predict based on each indicator in the blood, and was trained with all relevant indicators for comprehensive predictions. In our study, we found that there was a high statistical significance (p < 0.001) for all indicators of healthy individuals and early cancer patients, except for uric acid (UA). At the same time, ccRCC also presented great differences in most blood indicators between males and females. In addition, patients with ccRCC had a higher probability of developing a low ratio of albumin (ALB) to globulin (GLB) (AGR < 1.2). Eight key indicators were used to classify and predict renal cell carcinoma. The area under the receiver operating characteristic (ROC) curve (AUC) of the eight-indicator model was as high as 0.932, the sensitivity was 88.2%, and the specificity was 86.3%, which are acceptable in many applications, thus realising early screening for renal cancer by blood indicators in a simple blood-draw physical examination. Furthermore, the composite indicator prediction method described in our study can be applied to other clinical conditions or diseases, where multiple blood indicators may be key to enhancing the diagnostic potential of screening strategies.

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Primary renal osteosarcoma: A case report and review of literature

Cited by 3 publications

References 20 publications

A staghorn kidney stone or extraskeletal osteosarcoma of the kidney? A case report and literature review

A staghorn kidney stone or extraskeletal osteosarcoma of the kidney? A case report and literature review

Case report: A case of primary renal osteosarcoma

A Novel, Simple, and Low-Cost Approach for Machine Learning Screening of Kidney Cancer: An Eight-Indicator Blood Test Panel with Predictive Value for Early Diagnosis

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