Primary resistance of Helicobacter pylori to clarithromycin in different region of Hungary

Tiszai, A; Sükösd, Farkas; Lénárt, Z; Bálint, L; Kiss, Z. F; Rosztóczy, A; Garamszegi, M.; Váry, A.; Fricz, P; Rácz, I; Wittmann, Tibor

doi:10.1055/s-0030-1254829

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“…Ennek a világszerte tapasztalt jelenségnek [17,18] a következtében a hagyományos első vonalbeli eradicatiós terápiák hatékonysága 80% alá csökkent, ami elfogadhatatlanul alacsony [19]. Hazai szerzők több közleményben hívták föl a figyelmet arra, hogy az első vonalbeli kezelés hatékonysága Magyarországon is kritikusan alacsony, 75% alatti, aminek az oka lehet, hogy a H. p. kiirtására gyakorta alkalmazott antibiotikumokkal szembeni rezisztencia magas [17,[20][21][22][23]. Mindezek alapján javasolták új első vonalbeli kezelési protokoll bevezetését az eradicatio sikerességének növelésére [21].…”

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A Helicobacter pylori-fertőzés első vonalbeli megszüntetésére alkalmazott hagyományos hármas és egy új, bizmuttartalmú négyes kezelés összehasonlítása

Varga

Drácz

Kolbenheyer³

et al. 2019

Orvosi Hetilap

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Introduction and aim: As the efficacy of the first-line traditional treatment used to eradicate Helicobacter pylori (H. p.) decreased below 75% in Hungary, a new protocol had to be created. Method: Supposing the success rate of the traditional therapy (14-day double dose of proton pump inhibitor [PPI], 1000 mg amoxicillin b.i.d., 500 mg clarithromycin b.i.d. [PAC]) to be 75% and the efficacy of the new protocol (10-day 120 mg bismuth dicitrate q.i.d., double dose PPI b.i.d., 500 mg tetracycline q.i.d. and 500 mg tinidazole b.i.d. [BQT]) to be 90%, we calculated 109 patients on each arm. Patients were recruited after upper gastrointestinal endoscopy from 5 endoscopic units in Vas county. The heterogeneity of groups, success rate and side effects of both therapies were evaluated by Fisher exact test; p<0.05 was considered significant. Results: 110 patients were included in the BQT and 109 patients in the PAC group. There was no heterogeneity between the two groups in age, gender and indication of eradication. H. p. eradication was successful in 103/110 (93.6%) in the BQT and 81/109 (74.3%) in the PAC group (p<0.001). The odds ratio in the BQT group for successful eradication was 5.05 (95% confidence interval: 2.02–14.42) as compared to the PAC group (p<0.001). The side effects of the two groups were similar, in the BQT group the frequency was 34.5%. Conclusion: 10 day-long BQT containing double dose PPI with 120 mg bismuth dicitrate q.i.d., 500 mg tetracycline q.i.d. and 500 mg tinidazole b.i.d. is recommended as the first-line treatment for the eradication of H. p. because of its high efficacy and tolerable side effects. Orv Hetil. 2019; 160(34): 1340–1345.

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