2010
DOI: 10.1016/j.ijid.2009.06.021
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Primary retroperitoneal abscesses due to Rhodococcus equi in a patient with severe nephrotic syndrome: successful antibiotic treatment with linezolid and tigecycline

Abstract: We present a case of Rhodococcus equi primary retroperitoneal abscesses without pulmonary involvement in an immunocompromised patient with severe nephrotic syndrome. No risk factors for exposure to R. equi were present. The infection was successfully treated with long-term combination antibiotic treatment including linezolid and tigecycline.

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Cited by 10 publications
(14 citation statements)
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“…This may be caused by lower activity of renal immune mechanism [20] and was supported by Kato et al [21] showing that end-stage renal disease is associated with the state of immune dysfunction. In addition, Russo et al [22] also stated that immuno-compromised host with severe nephrotic syndrome was associated with risk factor of retroperitoneal abscess. Therefore, renal failure as risk factors suggested by those studies may offer the evidence and attention for the readers or physicians taking care of the patients with renal or retroperitoneal abscesses.…”
Section: Discussionmentioning
confidence: 99%
“…This may be caused by lower activity of renal immune mechanism [20] and was supported by Kato et al [21] showing that end-stage renal disease is associated with the state of immune dysfunction. In addition, Russo et al [22] also stated that immuno-compromised host with severe nephrotic syndrome was associated with risk factor of retroperitoneal abscess. Therefore, renal failure as risk factors suggested by those studies may offer the evidence and attention for the readers or physicians taking care of the patients with renal or retroperitoneal abscesses.…”
Section: Discussionmentioning
confidence: 99%
“…Other less commonly reported sites of infection were gastrointestinal, pericarditis, meningitis and mastoiditis with other cases of reported liver, kidney and psoas muscle abscesses [3]. It is unusual for rhodococcus to cause an infective endocarditis [4]. Here, we report a case of refractory rhodococcal infective endocarditis in an immunocompetent intravenous drug user.…”
Section: Introductionmentioning
confidence: 73%
“…As he groups of antibiotics. There had been no guideline published for treatment of Rhodococcus equi infection, with no standardised antibiotic regimen [4]. Based on expert opinions consensus, recommendation of treatment had been the utilization of at least two types of antibiotics from different classes for a minimum of two months duration [3], Relapse is quite common and therefore for full eradication of the infection and prevention of disease relapse, a long term course of maintenance antibiotic treatment is deemed necessary especially in an immunocompromised patient [4].…”
Section: Case Reportmentioning
confidence: 99%
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“…Combined antibiotic treatment is the cornerstone of the therapy for R. equi infection, but surgical incision and drainage of abscess formation can also be useful. Treatment of severe forms of the disease should start with combined parenteral antibiotics and after clinical and laboratory improvement should switch to a combined peroral antibiotic therapy, we also applied [37][38][39][40][41][42][43] . Because of high incidence of bacteriemia and large bacterial inoculum it is necessary to apply adequate combination of antibacterial drugs with bactericidal activity, with simultaneous application of lipophilic antibiotics with good intracellular penetration.…”
Section: Discussionmentioning
confidence: 99%