Primary Retroperitoneal Mucinous Cystadenomas with Gastric Epithelial Differentiation

Rothacker, D; Knolle, J.; Stiller, D; Borchard, F

doi:10.1016/s0344-0338(11)80844-7

Cited by 14 publications

(6 citation statements)

References 21 publications

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“…In fact, since Bassini's initial description in 1889 of a lesion with similar characteristics, 1 no more than 20 such cases have been documented in the literature to our knowledge. 2 The histogenesis remains unclear; however, four main hypotheses have been proposed to explain the origin of retroperitoneal mucinous tumors. First, these tumors may arise as teratomatous lesions in which the columnar epithelium has overridden all the other components to survive as the single cell component.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic resection of a primary retroperitoneal mucinous cystadenoma: Report of a case

et al. 1998

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Primary retroperitoneal mucinous cystic tumors are extremely rare, and although their histogenesis is still uncertain, several theories have been proposed. Traditionally, transabdominal laparotomy and enucleation of the cyst is the treatment of choice and laparoscopic resection has not previously been reported. This paper presents the case of a 48-year-old woman in whom a primary retroperitoneal cystic mass, 15 x 13 x 9 cm in size, was successfully resected through the laparoscope. Pathological examination revealed a mucinous cystadenoma with borderline malignancy. The patient had a prompt recovery and there was no evidence of recurrence at her 8-month follow-up. However, the prevention of cystic fluid spillage during laparoscopic manipulation is important, especially when the pathology of the retroperitoneal cyst is unclear.

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Section: Discussionmentioning

confidence: 99%

Laparoscopic resection of a primary retroperitoneal mucinous cystadenoma: Report of a case

et al. 1998

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“…Tenti et al studied nine biomarkers of gastric, intestinal and pancreatic ductal epithelium cells in mucinous ovarian adenocarcinoma and found that PGC expression levels in ovary benign tumours and borderline tumours were higher than that in ovary cancer ( P < 0.005) [52]. Rothacker et al also reported PGC expression in ovarian mucinous cystadenoma to prove gastric epithelial differentiation [53]. Fukushima et al compared the differential gene expression between the normal pancreatic ductal epithelial cells and mucinous cystic neoplasms cells, and found that PGC was one of the 114 genes overexpressed in neoplasms cells through oligonucleotide microarray analysis [54].…”

Section: Pgc Expression and Cancermentioning

confidence: 99%

Pepsinogen C expression, regulation and its relationship with cancer

Shen¹,

Jiang

Yuan

2017

Cancer Cell Int

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Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC’s functions is unclear. In normal physiological conditions, PGC is initially detected in the late embryonic stage and is mainly expressed in gastric mucosa. The in situ expression of PGC in gastric mucosa is decreased considerably in the process of superficial gastritis → atrophic gastritis → gastric cancer (GC), proving that PGC is a comparatively ideal negative marker of GC. Serum PGC, and PGA levels and the PGA/PGC ratio have satisfactory sensitivity, specificity and price–quality ratio for predicting high GC risk. Ectopic PGC expression is significantly increased in prostate cancer, breast cancer, ovary cancer and endometrial cancer. In those sex-related cancers high level PGC expression indicates better prognosis and longer survival. The regulation of PGC expression involves genetic and epigenetic alteration of the encoding PGC gene, hormones modulation and interactions between PGC with other transcription factors and protein kinases. More and more research evidence hinted that PGC has strong correlation with cancer. In the systematic review, we respectively elaborate the structure, potential physiological functions, expression characteristics and regulation of PGC, and especially focus on the relationship between PGC expression and cancer to highlight the role of PGC in the tumorigenesis and its application value in clinical practice.

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“…Primary retroperitoneal mucinous cystadenoma (RMC) and mucinous cystadenocarcinoma (RMCCa) are also very rare [15, 19±23]. Rothacker et al [23] reviewed 13 primary RMC and 15 primary RMCCa. These patients were all women, their ages ranging from 17 to 69 years (median 36 years).…”

Section: Pp [1±7]mentioning

confidence: 99%

“…The histogenesis of primary RMC and RMCCa is not clear, but it has been suggested that these tumors may arise from teratomas, ectopic supernumerary or accessory ovaries, or celomic metaplasia [20]. The derivation from celomic epithelium during gonadal descent is now the most widely accepted theory [23].…”

Section: Pp [1±7]mentioning

confidence: 99%