Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review

Bayramoğlu, Zuhal; Kebudi, Rejin; Yılmaz, Ravza; Bay, Sema Büyükkapu; Kebudi, Abut; Karanlık, Hasan; İribaş, Ayça; Darendeliler, Emin; Önder, Semen; Bılgıç, Bilge; Adaletli, İbrahim

doi:10.1159/000487750

Cited by 12 publications

(12 citation statements)

References 30 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sonographic examination has been shown to demonstrate an inhomogeneous, hypoechoic mass with defined margins and an oval shape, characteristics that are typically considered probably benign. RMS has also been shown to have posterior acoustic enhancement, a finding that has also been described with fibroadenomas [8].…”

Section: Discussionmentioning

confidence: 95%

“…All, in young females, with ages ranging from 11.5 to 20.2 years. A review of demographic data and treatment of 24 cases of primary RMs in children and adolescents previously reported in the literature, is reported by Bayramoglu et al (2018)[8]. There was only one IHC proven case of primary RMS of the breast, presenting after the fourth decade [1].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Trihia

Novkovic

Provatas

et al. 2019

Case Reports in Pathology

View full text Add to dashboard Cite

Sarcomas of the breast constitute less than 1% of all malignant breast tumors and primary rhabdomyosarcoma (RMS) is a very rare entity with limited case reports in the literature. RMS is common in children and adolescents and rare in adults. Primary RMS arising from the breast is exceedingly rare in adults. We report a case of a primary RMS of the breast in a 60-year-old woman, who presented in an early stage, mimicking invasive ductal carcinoma clinically and is in complete remission after three years of diagnosis and one year of treatment.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Trihia

Novkovic

Provatas

et al. 2019

Case Reports in Pathology

View full text Add to dashboard Cite

show abstract

“…It needs comprehensive treatment such as surgery and chemotherapy. 18 Surgery can be used only when the whole tumor can be resected or there is a little residue. If tumors cannot be completely resected or organs and their functions need to be preserved, chemotherapy can be used to reduce the size of the tumor before surgery.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical efficacy of Chemotherapy for Rhabdomyosarcoma in children

Ning¹,

Liu²,

Wei³

et al. 2020

Pak J Med Sci

View full text Add to dashboard Cite

Objective: To investigate the clinical characteristics and treatment methods of rhabdomyosarcoma in children and the efficacy of the methods. Methods: The clinical data of 30 children with rhabdomyosarcoma who were admitted to our hospital from August 2013 to August 2017 were retrospectively analyzed. The clinical characteristics were summarized, and the curative effect and prognosis were evaluated. Results: Among all the children (N=30), there were 20 males and 10 females, with a median age of 3.5 years. As to the primary site, there were 13 cases of head and neck, 11 cases of trunk, three cases of urogenital system and three cases of limbs. There were 25 cases of embryonic type, 4 cases of alveolar type and one case of polymorphic type. As to the clinical stage, there were one case of stage I, 9 cases of stage II, 13 cases of stage III and 7 cases of stage IV. There were one case of low risk, 19 cases of medium risk and 10 cases of high risk. Eight cases received surgery alone, 22 cases received combined treatment of surgery and chemotherapy (the chemotherapeutics followed three schemes, low-risk group (VAC+VA), moderate risk group (VAC) and high risk group (alternating use of VDC and IE). Among all the cases (N=30), there were 14 cases of complete remission (CR), five cases of partial remission (PR), four cases of stable disease (SD), and 7 cases of progressive disease (PD). The CR rate was (N=14, 46.7%). The three-year overall survival (OS) rate was (N=19, 63.3%). The clinical efficacy and prognosis of children receiving surgery and chemotherapy were better than those of children receiving surgery alone, and the difference was statistically significant (P<0.05). Conclusion: Rhabdomyosarcoma in children frequently happens in the head, neck and trunk. Embryonic type is the main pathological type of rhabdomyosarcoma. Comprehensive and standardized treatment based on surgery and chemotherapy is an important way to improve the curative effect in the treatment of rhabdomyosarcoma in children. doi: https://doi.org/10.12669/pjms.36.5.1829 How to cite this:Ning Z, Liu X, Qin G, Wei L, Li X, Shen J. Evaluation of clinical efficacy of Chemotherapy for Rhabdomyosarcoma in children. Pak J Med Sci. 2020;36(5):1069-1074. doi: https://doi.org/10.12669/pjms.36.5.1829 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

“…Breast RMS shows variable, non-specific imaging characteristics on mammography (oval or nodular mass) and ultrasonography (oval, hypoechoic, and inhomogenous mass) [8]. Cytologic subtyping of pediatric sarcomas by FNAC seems highly accurate technique and fulfills the needs as a quick, minimally invasive, safe, and accurate diagnostic procedure required to initiate pre-operative chemotherapy protocols [3].…”

Section: Discussionmentioning

confidence: 99%

Metastatic rhabdomyosarcoma of breast: A rare presentation

Gahlot¹,

Chatterjee²,

Mukherjee³

et al. 2020

IJCR

View full text Add to dashboard Cite

R habdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children constituting 3.5% of all cancers in them with the head and neck as the predominant site. RMS has a propensity to metastasize to the bone, bone marrow, lung, liver, brain, and lymph nodes in 14-28%, whereas, to the breast in 3.7-6.7% of cases [1,2]. Hays et al. (92%), Howarth et al. (86%), and D'Angelo et al. (100%) have observed alveolar RMS as the predominant histological subtype metastasizing to the breast [2]. Fine-needle aspiration cytology (FNAC) being a quick, safe, and economical technique, thus acquires an important role in providing morphological diagnosis for timely management [3]. FNAC smears show increased cellularity of discohesive, homogenous small round tumor cells with mildto-moderate cytological atypia, fine granular chromatin, and conspicuous nucleoli in a tigroid background [4].Histomorphology of trucut biopsy from the lesion shows primitive round to spindle cells having scant cytoplasm, hyperchromatic nuclei with admixed scattered rhabdomyoblasts exhibiting brightly eosinophilic abundant cytoplasm, and eccentric hyperchromatic nuclei. These tumor cells are immunopositive for desmin, muscle-specific antigen (MSA), myogenin, and negative for pan-cytokeratin, CD45, CD99, and synaptophysin, therefore, a definitive diagnosis of metastatic RMS of the breast was offered. The treatment of metastatic RMS of the breast comprises chemotherapy, radiotherapy, or surgery depending on the clinical profile. Embryonal RMS has a more favorable prognosis than alveolar or pleomorphic subtypes [5]. CASE REPORTA 16-year-old girl presented 2 years back with complaints of swelling over the right cheek and associated intermittent, scanty bleeding from the nose for 2 months duration. Contrast-enhanced computed tomography (CECT) of the nose and paranasal sinus revealed a large, heterogeneously enhancing soft-tissue mass in the right maxillary antrum associated with thinning/erosion of its wall thus suggestive of neoplastic etiology. Positron emission tomography-CT scan revealed FDG avid, heterogeneously enhancing soft-tissue mass in the right maxillary sinus measuring 5.1×4.3×5.4 cm with extension to the right ethmoidal, sphenoidal sinuses and reported as mitotic pathology.Biopsy from the right maxillary mass was reviewed at our hospital and diagnosed as embryonal RMS.

show abstract

Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review

Cited by 12 publications

References 30 publications

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Evaluation of clinical efficacy of Chemotherapy for Rhabdomyosarcoma in children

Metastatic rhabdomyosarcoma of breast: A rare presentation

Contact Info

Product

Resources

About