Primary rhegmatogenous retinal detachment – surgical methods and anatomical outcome

Haugstad, Marta; Moosmayer, Stefan; Bragadóttir, Ragnheiður

doi:10.1111/aos.13295

Cited by 80 publications

(81 citation statements)

References 21 publications

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“…In our study, the RRD eyes operated with conventional SB surgery without vitrectomy were not included or analysed. Rates of RRD patients undergoing vitrectomy have shown a more than 10-fold increase from 1985 to 2004 in UK (El-Amir et al 2009), and in our centre, vitrectomy has become the preferred surgical technique for primary RRD (Sahanne et al 2017), being in line with other latest studies (Poulsen et al 2016;Haugstad et al 2017).…”

Section: Discussionsupporting

confidence: 60%

Statin use and vitreoretinal surgery: Findings from a Finnish population‐based cohort study

Loukovaara

Sahanne

Takala

et al. 2018

Acta Ophthalmologica

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Section: Discussionsupporting

confidence: 60%

Statin use and vitreoretinal surgery: Findings from a Finnish population‐based cohort study

Loukovaara

Sahanne

Takala

et al. 2018

Acta Ophthalmologica

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“…The treatment of RD has dramatically improved over the past decades. Surgical procedures including scleral buckling, pars plana vitrectomy, and pneumatic retinopexy have been successfully used for the treatment of RRD, with primary success rates of up to 90% [ 6 , 8 , 9 ]. However, when RRD is associated with macular detachment, choroidal detachment (RRDCD) or PVR, the patients experience poor visual recovery and low reattachment rates [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

iTRAQ Quantitative Proteomic Analysis of Vitreous from Patients with Retinal Detachment

Santos

Gaspar

Ciordia

et al. 2018

IJMS

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Rhegmatogenous retinal detachment (RRD) is a potentially blinding condition characterized by a physical separation between neurosensory retina and retinal pigment epithelium. Quantitative proteomics can help to understand the changes that occur at the cellular level during RRD, providing additional information about the molecular mechanisms underlying its pathogenesis. In the present study, iTRAQ labeling was combined with two-dimensional LC-ESI-MS/MS to find expression changes in the proteome of vitreous from patients with RRD when compared to control samples. A total of 150 proteins were found differentially expressed in the vitreous of patients with RRD, including 96 overexpressed and 54 underexpressed. Several overexpressed proteins, several such as glycolytic enzymes (fructose-bisphosphate aldolase A, gamma-enolase, and phosphoglycerate kinase 1), glucose transporters (GLUT-1), growth factors (metalloproteinase inhibitor 1), and serine protease inhibitors (plasminogen activator inhibitor 1) are regulated by HIF-1, which suggests that HIF-1 signaling pathway can be triggered in response to RRD. Also, the accumulation of photoreceptor proteins, including phosducin, rhodopsin, and s-arrestin, and vimentin in vitreous may indicate that photoreceptor degeneration occurs in RRD. Also, the accumulation of photoreceptor proteins, including phosducin, rhodopsin, and s-arrestin, and vimentin in vitreous may indicate that photoreceptor degeneration occurs in RRD. Nevertheless, the differentially expressed proteins found in this study suggest that different mechanisms are activated after RRD to promote the survival of retinal cells through complex cellular responses.

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“…SB was introduced in 1957, and PPV in 1976 8,9. These techniques can also be used combined 10,11. During the last two decades, plenty of clinical studies have been published related to clinical risk factors, ocular characteristics, and features of RRD, as well as methods of reattachment surgery and development of instrumentation.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study comparing outcomes of primary rhegmatogenous retinal detachment repair by scleral buckling and pars plana vitrectomy in Finland

Sahanne¹,

Tuuminen²,

Haukka³

et al. 2017

OPTH

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BackgroundRhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment and an ophthalmic emergency. Here, we compared outcomes of primary RRD eyes operated with conventional scleral buckling (SB) with cryoretinopexy to those operated with standard pars plana vitrectomy (PPV).MethodsThis is an institutional, retrospective, register-based, observational, comparative study. Based on the surgical procedure, 319 eyes of 319 patients were divided into two groups: SB plus cryotherapy (n=50) and PPV (n=269). Changes in intraocular pressure (IOP) and best-corrected visual acuity (BCVA) were recorded at 30 days and reoperation rates within 180 days postoperatively.ResultsEyes operated with PPV had less reoperations within the first 180 days as compared with SB eyes (P=0.001, log-rank test); however, changes in IOP were more prominent (mean ± standard deviation: +8.1±8.8 vs. +4.4±7.0 mmHg, respectively; P=0.006). Changes in BCVA did not differ between the surgical procedures.ConclusionPPV was associated with higher primary anatomic success rates and lower risk of reoperation but significant IOP elevation when compared to SB. These factors should be case-specifically considered when choosing treatment modality for primary RRD.

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Primary rhegmatogenous retinal detachment – surgical methods and anatomical outcome

Cited by 80 publications

References 21 publications

Statin use and vitreoretinal surgery: Findings from a Finnish population‐based cohort study

Statin use and vitreoretinal surgery: Findings from a Finnish population‐based cohort study

iTRAQ Quantitative Proteomic Analysis of Vitreous from Patients with Retinal Detachment

A retrospective study comparing outcomes of primary rhegmatogenous retinal detachment repair by scleral buckling and pars plana vitrectomy in Finland

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