Primary sarcoma of the liver in the adult

Chang, Wenguang; Agha, Farooq P.; Morgan, Winfield S.

doi:10.1002/1097-0142(19830415)51:8<1510::aid-cncr2820510826>3.0.co;2-k

Cited by 53 publications

(21 citation statements)

References 20 publications

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“…Most hepatic tumors with sarcomatous features are sarcomatoid carcinoma, whereas true hepatic sarcomas are extremely rare. 3,4 Most investigators have found by histogenetic analysis that the sarcomatoid elements in liver cancers seen to be derived from a dedifferentiation of hepatocellular carcinomas (HCC), 5-8 although a few reports have described sarcomatoid dedifferentiation in the cancer cells of cholangiocellular carcinomas (CCC), namely, intrahepatic bile duct carcinomas. 9,10 In this report, we describe the immunohistochemical characteristics, including the epithelial and nonepithelial cell markers, of tumor cells in the liver of a 65-year-old man.…”

Section: Introductionmentioning

confidence: 99%

Malignant Sarcomatoid Tumor of the Liver: Report of a Case

et al. 2001

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A 65-year-old man was referred to our hospital for treatment of a liver tumor. Abdominal ultrasonography (US) demonstrated a low echoic mass in the S2-S4 region of the liver, which was confirmed by abdominal computed tomography (CT). In the delayed phase of angio-CT, the inside of the mass was not enhanced. Abdominal angiography showed a hypovascular area in the liver. An extended left lobectomy was performed. Macroscopically, the tumor was 9.5 x 9.5 cm in size, and on cross section, it was white and clearly demarcated from the surrounding tissue. Microscopic observation of hematoxylin-eosin-stained specimens did not show any glandular or trabecular formation. Histologically, there was diffuse proliferation of atypical spindle cells that had hyperchromatic, short, spindle-shaped nuclei, and pale cytoplasm with poor intercellular adhesion. The nontumorous tissue was almost normal with no sign of cirrhosis. Immunohistochemical examination showed that the spindle cells were positive for vimentin and cytokeratins (AE1/AE3, CAM 5.2), but negative for all other markers. The final diagnosis was a sarcomatoid carcinoma, the origin of which was not able to be confirmed immunohistochemically. This case of a primary hepatic tumor composed of malignant cells with sarcomatous features is described, and the immunohistochemical findings are discussed.

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Section: Introductionmentioning

confidence: 99%

Malignant Sarcomatoid Tumor of the Liver: Report of a Case

et al. 2001

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“…Among such histological varieties, a Correspondence to: H. Honda sarcomatous appearance has been sporadically reported [1][2][3][4][5][6][7][8][9]. Because of its poor prognosis, the diagnosis of HCC with sarcomatous change (HCCSC) is especially important.…”

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confidence: 99%

Hepatocellular carcinoma with sarcomatous change: characteristic findings of two-phased incremental CT

et al. 1996

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“…In most cases of UESL, no pre-existing liver disease is detected [28]; however, some of the middle-aged and elderly patients diagnosed with UESL also suffered from multiple sclerosis [22], concomitant coronary heart disease [5], CREST syndrome [6], or community-acquired pneumonia [12]. In addition, some of these patients have a past history of malaria [8] or cancer, including patients who have undergone resection for colonic carcinoma [8] or chemotherapy for ovarian cancer [15].…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of this rare disease remains largely unknown, especially in adult patients. However, a potential association with inflammatory disease has been suggested based upon some cases with co-morbidities, such as CREST syndrome, malaria, community-acquired pneumonia, cancer-related chemotherapy, and multiple sclerosis [6,8,12,15,22]. …”

Section: Introductionmentioning

confidence: 99%

Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus

et al. 2013

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Adult primary undifferentiated embryonal sarcoma of the liver (UESL) is a rare disease. While the etiology of UESL remains largely unknown, association with systemic inflammatory disorders has been observed. Here, we report a case of UESL in a 46-year-old woman with systemic lupus erythematosus (SLE) and without chronic hepatitis or liver cirrhosis. Systematic review of the publicly available English language medical literature identified only 27 cases of UESL in patients aged >45 years and none with SLE. Our patient presented with abdominal pain and had a 2-year history of SLE. Abdominal ultrasonography and enhanced computed tomography revealed a solid mass in the right lobe of the liver. Presumptive diagnosis of atypical hepatocellular carcinoma was made and the patient was treated with segmentectomy of S5 and S4a and cholecystectomy. The final diagnosis of UESL was made according to the pathology results. Since SLE patients may be at increased risk of malignancy, it is possible that the SLE pathogenesis may have contributed to the development of UESL in our patient. According to this case, UESL should be considered when SLE patients present with hepatic space-occupying lesions.

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Primary sarcoma of the liver in the adult

Cited by 53 publications

References 20 publications

Malignant Sarcomatoid Tumor of the Liver: Report of a Case

Malignant Sarcomatoid Tumor of the Liver: Report of a Case

Hepatocellular carcinoma with sarcomatous change: characteristic findings of two-phased incremental CT

Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus

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