Primary sclerosing cholangitis in childhood inflammatory bowel disease.

Stenhammar, Lars; Högberg, Lotta; Lewander, P

doi:10.1136/adc.71.3.281-b

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“…In addition, in classical UC an atypical Th2‐type inflammatory response was described with increased IL‐13 and IL‐4 levels,9 whereas in autoimmune disease predominant Th1 responses were reported. A subgroup of patients with colitis is characterized by an association with autoimmune diseases,10–16 most commonly primary sclerosing cholangitis (PSC),17–20 but also autoimmune hepatitis (AIH) or their combination (“overlap syndrome”) 21. The precise cause of this association is yet unknown.…”

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confidence: 99%