Primary sclerosing cholangitis: MR imaging findings with pathologic correlation.

Revelon, Geraldine; Rashid, Asif; Kawamoto, Satomi; Bluemke, David A.

doi:10.2214/ajr.173.4.10511174

Cited by 65 publications

(40 citation statements)

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“…Calcification and T1-weighted hyperintense areas were not present. The peripheral wedge-shaped lesion type with increased enhancement on arterial phase images corresponds well to the findings in primary sclerosing cholangitis (PSC) and may be attributed to decreased portal flow in this area [16,17]. The disseminated, partly circumscribed hyperechoic and hypoattenuated areas as well as the inhomogeneity emphasized with fat saturation in T1-weighted MR images are compatible with increased fat content.…”

Section: Discussionsupporting

confidence: 69%

MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans' cell histiocytosis

et al. 2001

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Langerhans' cell histiocytosis (LCH) is a disorder of histiocytic proliferation that primarily affects infants. Imaging findings of a rare case of lung and liver involvement in an adult are presented. High-resolution computed tomography (HRCT) of the lungs showed confluent thin-walled cystic air spaces compatible with advanced LCH. Liver CT and MRI revealed unspecific signs of fatty infiltration. Irregular widening of peripheral bile ducts was displayed in breath-hold MR cholangiography. This pattern is considered characteristic for sclerosing cholangitis and should support the diagnosis of LCH in case of concomitant cystic pulmonary disease, even in adult patients.

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Section: Discussionsupporting

confidence: 69%

MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans' cell histiocytosis

et al. 2001

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“…The risks are probably greater in patients with PSC than those with other diagnoses, and instances of life-threatening and even fatal cholangitis have been reported. In recent years, MR techniques have been developed and improved such that MRCP has replaced ERCP for diagnosis of PSC in many centers 43,44,49,50 (Fig. 3).…”

Section: Session Two Diagnosis and Assessment Of Primary Sclerosing mentioning

confidence: 99%

Primary sclerosing cholangitis: Summary of a workshop

et al. 2006

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Primary sclerosing cholangitis (PSC) is a rare but important liver disease that leads to cirrhosis and need for liver transplantation in a high proportion of cases. The disease occurs in approximately 1 per 100,000 population per year, usually presents in adulthood, and affects men more often than women. Typical serum biochemical results, autoantibodies and liver biopsy are suggestive but not diagnostic of PSC, the diagnosis requiring cholangiographic demonstration of stricturing and dilatation of the intra-and/or extra-hepatic bile ducts. The natural history of PSC is variable, the average survival being 12 to 17 years. The cause of PSC is still unknown. Although considered an autoimmune disease, PSC has several atypical features and a strong genetic component. The therapy of PSC is unsatisfactory. Standard doses of ursodeoxycholic acid (UDCA) lead to improvements in biochemical abnormalities but not in histology, cholangiographic appearance or survival. Several innovative therapies have been tried in PSC, but with scant evidence of benefit. For patients with high grade strictures, endoscopic dilatation is beneficial. Liver transplantation is successful for end-stage liver disease due to PSC and improves survival. PSC may recur after transplantation but is rarely progressive. The most dreaded complication of PSC is cholangiocarcinoma. Diagnosis of this highly malignant tumor is difficult, and there are no biomarkers for its early detection. Liver transplantation for cholangiocarcinoma has an exceedingly poor outcome, although transplantation with neoadjuvant chemoirradiation holds promise in selected patients. Thus, significant opportunities remain for basic and clinical research into the cause, natural history, and therapy of PSC. 44:746-764.)

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“…As to the absence of first ductules, it is important for clinical practice for two reasons: the first as a sign of fibro-obliterative deseases [18][19][20][21][22][23][24][25][26] and the second considering minimum detectable duct caliber in imaging radiologic researches [27][28][29]. From LDLT point of view it is important in evaluation of age and functional-size-mass related liver parenchyma changes for donors and recipients.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Confluence of Intrahepatic Biliary Ducts - A Case Report

Jurkovikj

Korneti-Pekevska

2013

Maced J Med Sci

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Aim: Besides the most frequent-modal type of confluent patterns intrahepatic biliary ducts, there are cases with aberrant type of confluence. The aim of this report is to present a case with aberrant confluence of intrahepatic biliary ducts. Material and Methods:Injection-corrosive method was used to obtain acrylic cast from biliary and portal systems of one human liver. Biliary ducts were followed parallel to the adjoint portal ramification from the initial part of segmental ductules.

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Primary sclerosing cholangitis: MR imaging findings with pathologic correlation.

Cited by 65 publications

References 0 publications

MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans' cell histiocytosis

MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans' cell histiocytosis

Primary sclerosing cholangitis: Summary of a workshop

Aberrant Confluence of Intrahepatic Biliary Ducts - A Case Report

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