Primary seminal vesicle carcinoma. The usefulness of PAX8 immunohistochemical expression for the differential diagnosis

Posenato, Ilaria; Caliò, Anna; Segala, Diego; Sgroi, Salvatore; Polara, Andrea; Brunelli, Matteo; Martignoni, Guido

doi:10.1016/j.humpath.2017.05.003

Cited by 17 publications

(18 citation statements)

References 27 publications

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“…including digestive and urinary tumors, has also been shown to be a biomarker for the diagnosis of ovarian and kidney cancer, and has been the focus of researchers [25,26]. Recently, the effect of PAX8 has been indicated to support the clearance of tumor cells and be the prediction of survival time in tumor patients [12].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Evaluation of PAX8 Expression Promotes the Proliferation of Stomach Cancer cells

Deng

et al. 2019

Preprint

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Background PAX8 was not only a mitotic factor, but identified as a transcription factor involved in the prognosis of human tumor patients. Elucidating the function of PAX8 on the pathology of stomach cancer was meaningful. Results: PAX8 was found to be upregulated in primary stomach cancer tissue and the TCGA stomach cancer dataset. Interestingly, SOX13 and PAX8 showed consistent expression patterns, and the combined high PAX8 and SOX18 expression induced a worse prognosis of stomach cancer patients. SOX13 was further identified as a transcription factor of PAX8, and further affect Aurora B and Cyclin B1 expression, two cell cycle related factors of the downstream of PAX8, including. Furthermore, PAX8 depletion inducted G1-phase arrest and the decrease of EdU incorporation, cell viability and colony formation can be rescued by SOX13 overexpression. Conclusions: SOX13 participated in the elevated expression of PAX8, which promote the proliferation of stomach cancer cells. Therefore, SOX13 mediated PAX8 expression was recognized as a tumor-promoting role in stomach cancer.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Evaluation of PAX8 Expression Promotes the Proliferation of Stomach Cancer cells

Deng

et al. 2019

Preprint

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“…However, it was later realised to be less specific owing to its positivity in colorectal carcinomas (Hamada et al, ). Newer markers for PSVA are CA‐125 and PAX‐8 (Ormsby et al, ; Posenato et al, ). In the current case, we have ruled out all the possibilities of malignancies from the neighbouring structures as well as defined the neoplastic nature of the lining cells.…”

Section: Discussionmentioning

confidence: 99%

“…On IHC, these atypical cells lining the papillary structures were positive for CK7, CA125 and PAX-8, and negative for PSA, AMACR, CK20, CDX-2, p63, GATA3, WT1, and calretinin. The Ki-67 index is about 30%-40% in these cells ( Figure 2 PSVA is an extremely rare tumour, with about 100 cases reported in the literature (Campobasso, Fornia, Ferretti, Maestroni, & Cortellini, 2012;Egevad, Ehrnström, Håkansson, & Grabe, 2007;Katafigiotis et al, 2016;Montironi et al, 2014;Ormsby, Haskell, Jones, & Goldblum, 2000;Oxley, Brett, Gillatt, & Burton, 1999;Posenato et al, 2017;Terrisse et al, 2017;Thiel & Effert, 2002;Yin & Jiang, 2018). The mean age of presentation is 62 years (range, 17-90 years).…”

Section: A S E Rep Ortmentioning

confidence: 99%

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Primary seminal vesicle adenocarcinoma: A case report of rare entity and discussion of its differential diagnosis using immunohistochemical approach for the core biopsy specimen

et al. 2020

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Primary seminal vesicle adenocarcinoma is a rare malignancy of the male genito‐urinary system with only a few confirmed reported cases. Initial tissue diagnostic modality is often a core biopsy specimen. Here, we report this rare entity in a 50‐year‐old male, highlighting the histomorphological and immunohistochemical approach to the core biopsy specimen of the seminal vesicle mass. The patient presented with a history of haematospermia and gross haematuria for one year, and radiological workup was found to have a right seminal vesicle mass. A trans‐rectal ultrasound guided core biopsy revealed a tumourous lesion with a predominant papillary architecture and cytological features of neoplasia. Based on positivity for CK7, PAX‐8 and CA‐125, and Ki‐67 index of 30%–40% and negativity for PSA, AMACR, CK20, CDX‐2, p63, GATA3, WT1 and calretinin, a diagnosis of primary seminal vesicle adenocarcinoma was offered. The diagnosis was also confirmed on the surgically resected specimen. This case depicts the approach of a pathologist to diagnose this rare entity on the core biopsy specimen and the possible differential diagnoses one must consider.

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“…Therefore, researches on molecules and signal transduction pathways participating in the regulation of gastric cancer cell proliferation is still one of the hot areas of recent research on gastric cancer [23,24]. Studies have shown that PAX8 is usually up-regulated in digestive system tumours and urinary system tumours, and PAX8 has been identified as a diagnostic marker for ovarian cancer and renal cell carcinoma [25,26]. Recent studies have shown that PAX8 has a direct or indirect effect on cell growth and survival [12].…”

Section: Discussionmentioning

confidence: 99%

SOX13 dependent PAX8 expression promotes the proliferation of gastric carcinoma cells

Bie

Yan

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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PAX8 is identified as a regulator in the pathogenesis of human tumours and an indicator of the prognosis for patients. However, the role of PAX8 on proliferation in gastric cancer have not been studied. This study was aimed to explore the expression pattern of PAX8 in gastric cancer, and investigate the effect of PAX8 on the proliferation of gastric cancer cells. PAX8 and SOX13 were identified to be synchronously up-regulated in primary gastric cancer in human gastric cancer tissues and the gastric cancer datasets of TCGA, and gastric cancer patients of combined high PAX8 and SOX13 expression showed poor prognosis. Furthermore, SOX13 can mediate PAX8 and its targeted genes, Aurora B and Cyclin B1, expression in AGS and MGC803 cell lines. Flow cytometry and EdU incorporation assays showed that silencing PAX8 can block the cell cycle of gastric cancer cell in G1 phase and SOX13 expression can rescue the arrested proliferative process induced by PAX8 silenced in CCK8 and colony formation assays. Thus, combined SOX13 and PAX8 expression regulate the proliferation of gastric cancer cells, and both SOX13 and PAX8 play an oncogene function in gastric cancer. ARTICLE HISTORY

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Primary seminal vesicle carcinoma. The usefulness of PAX8 immunohistochemical expression for the differential diagnosis

Cited by 17 publications

References 27 publications

WITHDRAWN: Evaluation of PAX8 Expression Promotes the Proliferation of Stomach Cancer cells

WITHDRAWN: Evaluation of PAX8 Expression Promotes the Proliferation of Stomach Cancer cells

Primary seminal vesicle adenocarcinoma: A case report of rare entity and discussion of its differential diagnosis using immunohistochemical approach for the core biopsy specimen

SOX13 dependent PAX8 expression promotes the proliferation of gastric carcinoma cells

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