Primary Signet Ring Cell Adenocarcinoma of the Urinary Bladder: A Report of 2 Cases

Boukettaya, Wiem; Feki, J.; Toumi, Nabil; Khanfir, Afef; Boudawara, Tahia; Daoud, J.; Frikha, M.

doi:10.1016/j.eucr.2014.03.004

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Furthermore, the histological appearance of primary signet-ring cell carcinoma of the urinary bladder is the same as that of other sites. Thus, evaluation of other primary sites is mandatory in view of excluding a metastasis [ 13 ]. In a female patient, possible primary tumours include tumours from colon, breast, and genital system that should be considered as differential diagnosis [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature

Jayarajah

Fernando

Herath

et al. 2017

Case Reports in Urology

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Primary signet-ring cell carcinoma is a variant of adenocarcinoma which is extremely rare, associated with poor prognosis and generally found to be resistant to chemotherapy and radiotherapy. We report a case of primary signet-ring cell carcinoma of the bladder which was successfully treated with partial cystectomy. A 71-year-old female with a history of type 2 diabetes, hypertension, and ischaemic heart disease presented with painless haematuria for 2 months' duration. The abdominal ultrasonography showed a localised polypoidal vesical growth arising from the bladder dome. Cystoscopy revealed an exophytic solid tumour in the anterior fundal wall. A deep transurethral resection of bladder tumour was done and histology revealed an adenocarcinoma composed of mucinous and signet-ring cell components. Later, considering the patient's age and the poor general condition, a partial cystectomy was done. Follow-up cystoscopy and ultrasonography were done at 12 months and there was no evidence of tumour recurrence and the patient is currently symptom-free. Partial cystectomy may be considered in patients with localised tumour without evidence of metastasis and poor general condition. Regular cystoscopies and ultrasound imaging are necessary for follow-up and early identification of recurrences.

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Section: Discussionmentioning

confidence: 99%

Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature

Jayarajah

Fernando

Herath

et al. 2017

Case Reports in Urology

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“…However, in line with signet ring cell carcinoma of bladder and stomach, both 5-Fluorouracil and Cisplatin-based chemotherapy regimens have been reported. Our patient had good response with Cisplatin-based chemotherapy [4,13].…”

Section: Discussionmentioning

confidence: 56%

“…On the other hand, squamous cell carcinoma contributes to 80%, transitional cell carcinoma to 10% and adenocarcinoma to 10% of UC in the bulbo-membranous urethra [2]. Adenocarcinoma of the urethra arises from the periurethral glands and can be of the following subtypes-enteric, not otherwise specified, mucinous, clear cell and signet ring cell [3].Primary signet ring cell adenocarcinoma of the urinary tract is extremely rare, with only a handful of cases involving the bladder and upper tracts and female urethra [4][5][6][7]. Our case is the first report of signet ring cell adenocarcinoma of the male urethra in the English literature.…”

Section: Discussionmentioning

confidence: 99%

“…Primary signet ring cell carcinoma of the urethra is an extremely rare disease, and therefore, treatment protocols for this malignancy are unclear. The treatment is usually extrapolated from signet ring cell adenocarcinoma occurring in other organs of the genitourinary tract [4,6]. Distal UC can be treated by penile preserving procedures with or without pelvic lymph node dissection [11].Positive surgical margins, lymphovascular invasion and perineural invasion are risk factors for recurrence after penile preserving surgeries [12].Radical cystoprostatectomy with urethrectomy/penectomy and bilateral pelvic lymph node dissection is the surgical treatment of choice in proximal tumours [12].…”

Section: Discussionmentioning

confidence: 99%

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Primary signet ring cell carcinoma of the male urethra

Joseph¹,

Chinnathambi²,

Jamburaj³

2022

ecancer Journal

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Malignant tumours of the male urethra are rare and commonly present at an advanced stage. The most common type of urethral cancer is urothelial carcinoma, followed by squamous cell carcinoma. Less than 5% of urethral cancers are adenocarcinoma. We report a young male with signet ring cell carcinoma of the membranous urethra who presented with recurrent lower urinary tract symptoms. Although he was initially treated for a urinary tract infection, the correct diagnosis was made with an appropriate imaging workup. He underwent radical urethrectomy with total pelvic exenteration with bilateral extended pelvic lymph node dissection. Ileal conduit and colostomy were performed as urinary and bowel diversions, respectively. The patient received adjuvant chemotherapy, however, succumbed to COVID-19 8 months after the procedure. This case has been presented to highlight the high index of suspicion required to diagnose this rare malignancy.

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“…Linitis plastica has been reported in signetring cell adenocarcinoma of the GI tract and bladder. 1,2 It was first coined in 1854 by William Brinton to describe the leather bottle shape of the stomach. 3 Over time, the term linitis plastica has been extended to include macroscopic thickening and reduced elasticity of any hollow organ.…”

Section: Discussionmentioning

confidence: 99%