Primary Signet-Ring Cell Carcinoma of the Urinary Bladder
(Linitis plastica)

Ponz, M. Serrano; Luzuriaga, Jon; Je, Robles García; Guillén, Francisco J.; Jm, Urmeneta Sanromá; Salva, Antonio José Ramis; Jj, Zudaire Bergera; Jm, Berián Polo

doi:10.1159/000472497

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…Due to the growth pattern of diffuse infiltration and early propensity of metastasis [13,14] , transurethral resection and partial cystectomy carry the risk of incomplete tumor removal. Therefore, radical cystectomy appears to be the treatment of choice [24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, most patients present in middle age with symptoms indistinguishable from the much more common urothelial carcinoma of the bladder. Signet-ring cells first invade the mucosa and submucosa of a hollow organ with eventual fullthickness involvement [11][12][13] . This pattern of invasion can produce extensive lateral spread without the development of a protruding neoplasm.…”

Section: Introductionmentioning

confidence: 99%

“…The histogenesis of SRCC of the urinary bladder remains a matter of controversy [13][14][15][16][17] . Three theories have been suggested in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

Wang

2011

Urol Int

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Objective: The aim of this study was to examine the epidemiology, natural history, treatment pattern and predictors of long-term survival of patients with signet-ring cell carcinoma (SRCC) of the urinary bladder based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database. Methods and Results: In total, 230 patients with pathologically confirmed SRCC of the urinary bladder were identified between 1973 and 2004. The mean age was 65 ± 13 years. Overall, 75.7% of the patients had a poorly differentiated or undifferentiated histology grade, 26.5% presented with metastatic disease, 59 (25.7%) underwent transurethral resection for bladder tumor only and 107 (46.5%) had partial or radical cystectomy. The 1-, 3- and 10-year cancer-specific survival rates were 66.8, 40.6 and 25.8%, respectively. Using multivariable Cox proportional hazard model, age (HR 1.024; p = 0.004), stage (distant vs. local, HR 6.2; p < 0.001) and cystectomy (HR 0.53; p = 0.002) were identified as independent predictors for cancer-specific survival. Conclusions: Receipt of cystectomy was strongly associated with improved survival in the patients with SRCC of urinary bladder. However, many patients with localized tumors did not receive potentially curative cystectomy. Further studies to address the barriers to the delivery of appropriate care to these patients are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

Wang

2011

Urol Int

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“…In our study, the most common surgery for PSRCC was TURB (49, 31.2%), followed by radical cystectomy with reconstruction (42, 26.8%). Due to the infiltrative pattern of growth and the early propensity of metastasis, nevertheless, certain scholars [ 23 , 24 ] reported that TURB and partial cystectomy carry the risk of tumor recurrence. Therefore, radical cystectomy appears to be the treatment of first choice [ 25 – 27 ].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics and Prognostic Factors of Primary Bladder Signet Ring Cell Carcinoma

Liu

Wang

Yuan

2022

Journal of Healthcare Engineering

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Introduction. The aim of this study is to examine the treatment pattern and predictors of long-term survival of patients with primary signet ring cell carcinoma (PSRCC) of the urinary bladder based on the analysis of the SEER database. Methods. The 3-year and 5-year overall survival (OS) and cancer-specific survival (CSS) were calculated using the Kaplan–Meier method. Then, we compared the CSS curves by the log-rank test. The independent risk factors were determined using univariate and multivariate Cox regression. Results. The 3-year OS and CSS rates for PSRCC of the bladder were 25.3% and 33.3%. The 5-year OS and CSS rates for the entire cohort were 16.4% and 25.2%. The CSS rates, respectively, were 0, 25.0, 66.7, 33.2, 42.4, and 31.7% at 3 years and 0, 25.0, 34.3, 24.1, 27.2, and 31.7% at 5 years for none, transurethral resection of the bladder (TURB), partial cystectomy, radical cystectomy with reconstruction, pelvic exenteration, and other surgeries (P = 0.001). Multivariate analyses showed independent risk factors only including T stage, M stage, lymph node removal, and surgical approach. Conclusions. T stage, M stage, lymph node removal, and surgical approach are independent risk factors of PSRCC of the urinary bladder. TURB and radical cystectomy with reconstruction appear to provide a better outcome.

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“…Whilst haematuria is the most common presenting symptom for conventional transitional cell carcinoma of the bladder, up to 40% of cases of bladder SRCC do not present with haematuria, with dysuria or distant symptoms being the most common initial features [4,8]. This differing mode of presentation may relate to the pattern of growth of SRCC which characteristically infiltrates the submucosa without projecting into the lumen of the bladder, and it can present with advanced disease or a linitis plastica like picture despite relatively normal cytsoscopy findings [4,9,10].…”

Section: Presentation and Diagnosismentioning

confidence: 99%

Signet Ring Cell Carcinoma of the Bladder and Urachus

Aggarwal

Christmas

Seckl

et al. 2011

British Journal of Medical and Surgical Urology

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Primary signet ring cell carcinomas (SRCCs) of the bladder and urachus are extremely rare malignancies with only 28 cases of urachal SRCC recorded and bladder SRCC comprising less than 0.1% of bladder malignancies.These rare cases of urothelial SRCC occur largely in men and the disease characteristically presents in patients in their 40s for urachal SRCC and 60s for bladder SRCC. Despite the rarity of the diagnosis, a knowledge of the natural history and management of urothelial SRCC may be valuable as the illness has a number of important differences from conventional bladder TCC.The characteristic pathological findings of sub-mucosal infiltration and spread are often reflected in the clinical presentation and progress of the disease. Bladder SRCC is frequently characterised by a late presentation at an advanced stage, with dysuria the most frequent presenting symptom whilst haematuria is relatively rare. Metastatic spread can occur with retroperitoneal disease that can be difficult to visualise on imaging and can lead to ureteric or small bowel obstruction.As a result of their rarity there is no structured clinical research in urothelial SRCC and the optimal management of early and advanced cases of this rare tumour is unknown. A number of differing chemotherapy regimens have been reported for advanced disease in various case reports and series with variable responses and generally modest benefits.

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Primary Signet-Ring Cell Carcinoma of the Urinary Bladder (Linitis plastica)

Cited by 8 publications

References 10 publications

Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

Clinicopathological Characteristics and Prognostic Factors of Primary Bladder Signet Ring Cell Carcinoma

Signet Ring Cell Carcinoma of the Bladder and Urachus

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