Primary signet‐ring cell carcinoma of the urinary bladder

Torenbeek, R.; Koot, R.A.C.; Blomjous, C. E. M.; Bruin, Peter C. de; Newling, Don; Meijer, Chris J.L.M.

doi:10.1046/j.1365-2559.1996.262303.x

Cited by 38 publications

(35 citation statements)

References 30 publications

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“…This appears related to a linitis plastic-like growth pattern rendering cystoscopic detection difficult and the outlook poor. 7 Adeno-or signet-ring cell carcinomas identified in the bladder are rare entities and may represent metastases from other primary sites, usually from the gastrointestinal tract. Clinical imaging and immunohistochemical findings in our patient were compatible with the primary source of signet cell cancer arising from the bladder.…”

Section: Discussionmentioning

confidence: 99%

Metastatic signet-ring cell cancer of the bladder responding to chemotherapy with capecitabine: case report and review of literature

Michels

Barbour

Cavers

et al. 2013

CUAJ

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Signet-ring cell cancers deriving from the bladder are rare entities and usually present with advanced incurable disease and associated poor outlook. No standard effective chemotherapeutic option has been described largely due to the rarity of this malignancy. We report a case of a patient with metastatic bladder cancer, signet-ring cell variant. The patient progressed rapidly on standard first-line bladder cancer chemotherapy with gemcitabine and carboplatin. He responded well to second-line capecitabine with a clinically meaningful progression-free survival.

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Section: Discussionmentioning

confidence: 99%

Metastatic signet-ring cell cancer of the bladder responding to chemotherapy with capecitabine: case report and review of literature

Michels

Barbour

Cavers

et al. 2013

CUAJ

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“…9 In the recent WHO classification of urinary system tumor (2004), infiltrative urothelial carcinoma with a component Pure signet-ring cells carcinoma is a highly malignant deep-infiltrating tumor with a very poor outcome. 14 The real content of the vacuoles in the cytoplasm of lipoid cells remains uncertain. Borzacchiello et al 3 have reported a case of lipid-cell variant of urothelial carcinoma of the urinary bladder in a cow.…”

Section: Discussionmentioning

confidence: 99%

Lipoid-cell Variant of Urothelial Carcinoma: A Clinicopathologic and Immunohistochemical Study of Five Cases

Leroy¹,

Gonzalez²,

Zini

et al. 2007

American Journal of Surgical Pathology

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Invasive urothelial carcinoma may present with many deceptive morphologic variants. We report the clinicopathologic and immunohistochemical features of 5 cases of the so-called lipid-cell variant of urothelial carcinoma. The tumors occurred in 4 men and 1 women aged from 56 to 80 years. Four cases were developed in the bladder and 1 case in the renal pelvis. All cases were revealed by a macroscopic hematuria. The tumors were composed of sheets and nests of large epithelial cells with an abundant clear multivacuolated cytoplasm mimicking lipoblasts. Nuclei were irregular, hyperchromatic, eccentric, and frequently indented by cytoplasmic vacuoles. Mucin stains (PAS, Alcian Blue) were negative. Tumor cells were strongly stained with cytokeratin 7, cytokeratin 20, and EMA but were negative with S-100 protein. In all cases, a usual high-grade urothelial carcinoma component was admixed with lipoid tumor cells. Two tumors infiltrated the bladder muscle, 2 cases invaded the bladder submucosa, and 1 case invaded the renal parenchyma. In the follow-up, despite appropriate surgical treatment, 4 patients died of the disease and 1 patient is alive without recurrence. Because of its rarity and the tumor cells' appearance, the lipoid-cell variant may be misdiagnosed and must be distinguished from liposarcoma or signet-ring cell carcinoma. In the present series, the lipoid-cell variant of urothelial carcinoma was associated with an aggressive behavior and a poor prognosis.

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“…Such adenocarcinomas are thought to arise from totipotent cells of the transitional epithelium or from the remnants of the cloaca. [5]…”

Section: Discussionmentioning

confidence: 99%

A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation

et al. 2011

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Primary signet ring cell adenocarcinoma (PSRCC) of the bladder is a relatively rare variant of adenocarcinoma of the bladder with poor prognosis. Also PSRCC of the bladder presenting with spontaneous urinary extravasation is very rare. We present the case of a 48-year male who presented with spontaneous urinary extravasation and was diagnosed to have PSRCC of the urinary bladder on evaluation. He was treated with radical cystectomy and adjuvant chemotherapy. This report emphasizes the need to rule out other primary sites of adenocarcinoma in the body, which may metastasize to the urinary bladder.

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Primary signet‐ring cell carcinoma of the urinary bladder

Cited by 38 publications

References 30 publications

Metastatic signet-ring cell cancer of the bladder responding to chemotherapy with capecitabine: case report and review of literature

Metastatic signet-ring cell cancer of the bladder responding to chemotherapy with capecitabine: case report and review of literature

Lipoid-cell Variant of Urothelial Carcinoma: A Clinicopathologic and Immunohistochemical Study of Five Cases

A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation

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