Primary Sjoegren's Syndrome Complicated by Sarcoidosis.

Miyata, Masayuki; Takase, Yuuko; Kobayashi, Hiroko; Kokubun, Masae; Yoshimura, Akiko; Y, Katsuura; Nishimaki, Tomoe; Kasukawa, Reiji

doi:10.2169/internalmedicine.37.174

Cited by 18 publications

(7 citation statements)

References 19 publications

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“…To our knowledge, about 10 cases with SS and sarcoidosis have been reported previously [11][12][13][14]. The reason why non-caseating granulomas were seen only in the mediastinal lymph node and not in the pulmonary nodular lesions was unclear.…”

Section: Discussionmentioning

confidence: 96%

Lymphocytic interstitial pneumonia and non-caseating epithelioid granuloma in mediastinal lymph nodes in a patient with primary Sjögren’s syndrome

Banno

Matsumoto

Sugiura

et al. 1999

Japanese Journal of Rheumatology

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A 63-year-old woman diagnosed with Sj6gren's syndrome (SS) was indicated as having interstitial pneumonia with enlarged mediastinal lymph nodes. Lung tissue specimens showed lymphocytic interstitial pneumonia (LIP) and non-caseating epithelioid granulomas were recognized in only the mediastinal lymph nodes. Monoclonality was not detected using polymerase chain reaction of IgH rearrangement. The pulmonary lesions including lymphadenopathy were remarkably reduced by admistration of prednisolone. In this case, the sarcoid-like granulomas may have been associated with LIE rather than co-existence of SS with sarcoidosis.

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Section: Discussionmentioning

confidence: 96%

Lymphocytic interstitial pneumonia and non-caseating epithelioid granuloma in mediastinal lymph nodes in a patient with primary Sjögren’s syndrome

Banno

Matsumoto

Sugiura

et al. 1999

Japanese Journal of Rheumatology

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“…Several drugs are reported to produce a BS-like phenotype, including aminoglycosides [ 11 , 12 ], colistin [ 13 ], and amphotericin B [ 14 ]. Acquired BS is reported in autoimmune conditions such as Sjögren’s disease [ 15 ] and granulomatous conditions like sarcoidosis [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Bartter syndrome-like phenotype in a patient with diabetes: a case report

2018

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BackgroundBartter’s syndrome is a rare genetic tubulopathy affecting the loop of Henle leading to salt wasting. It is commonly seen in utero or in early neonatal period. Rare cases of acquired Bartter’s syndrome are reported in association with infections like tuberculosis, granulomatous conditions like sarcoidosis, autoimmune diseases, and drugs. The mainstay of management includes potassium, calcium, and magnesium supplementation.Case presentationWe report the case of a 62-year-old Sri Lankan Sinhalese man with diabetes and hypertension presenting with generalized weakness with clinical evidence of proximal myopathy. He was severely hypokalemic with high urinary potassium excretion and hypochloremic metabolic alkalosis. He poorly responded to intravenously administered potassium supplements. A diagnosis of idiopathic Bartter-like phenotype was made. He responded well to spironolactone and indomethacin.ConclusionsPatients presenting with body weakness need serum potassium estimation. Acquired Bartter’s syndrome although rare, should be ruled out in those with hypokalemia and metabolic alkalosis with increased urinary potassium loss with poor response to potassium replacement.

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“…The various cutaneous manifestations of SS include dry skin, immunological inflammatory conditions such as vasculitis, and hypergammaglobulinemic purpura (4). Among them, in rare cases, SS is associated with granulomatous disorders, such as sarcoidosis (5). We describe here a case of GPPD associated with SS and demonstrate immunohistochemical staining for granuloma-forming cells, focusing especially on Foxp3+ regulatory T cells.…”

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confidence: 87%