Primary Sjögren's Syndrome After Infectious Mononucleosis

Whittingham, Senga; McNeilage, Jane; Mackay, Ian R.

doi:10.7326/0003-4819-102-4-490

Cited by 79 publications

(25 citation statements)

References 14 publications

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“…Several previous studies (26)(27)(28)(29) have implicated EBV in other types of autoimmune diseases. Most rheumatoid arthritis patients (70-90%) have antibodies directed against the rheumatoid arthritis precipitant, which is an antigen extracted from EBV-infected cells, and >90% of the patients have antibodies to the rheumatoid arthritis nuclear antigen (26).…”

Section: Discussionmentioning

confidence: 99%

“…Most rheumatoid arthritis patients (70-90%) have antibodies directed against the rheumatoid arthritis precipitant, which is an antigen extracted from EBV-infected cells, and >90% of the patients have antibodies to the rheumatoid arthritis nuclear antigen (26). Some patients with acute polyarthritis were also found to have EBV (27)(28)(29). Thus, in addition to ND-associated diseases, EBV may be involved directly or indirectly in several types of autoimmune disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

Xie

Snyder

1995

Proc. Natl. Acad. Sci. U.S.A.

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To understand the relationship between antibodies present in patients with anti-nuclear dot (ND) autoimmune disease and the proteins they recognize, epitopes that react with the autoantibodies were mapped. A panel of fusion proteins containing different portions of the ND protein were overproduced in Escherichia coli. Immunoblot analysis with anti-ND antibodies revealed that most (10 of 12) sera recognize two major autoepitopes that are each a maximum of 8 amino acids long. The other two sera recognize one of the two epitopes. In addition to the short linear autoepitopes, a conformational epitope appears to be present on the ND antigen. Each of the two linear epitope sequences shares sequence similarities with those of several viral proteins found in the databases. Furthermore, two fusion proteins containing short Epstein-Barr virus (EBV) protein sequences that are similar to the ND epitopes were recognized by the human autoimmune sera, indicating that the autoepitopes are present in EBV protein sequences. Our results are consistent with the hypothesis that ND autoimmune disease might be associated with EBV infections. Anti-nuclear antibodies are found in a variety of different autoimmune disease patients. In many cases, the reactivity of the antibody produced often correlates with the particular disease (e.g., ref. 1). Despite this fact, the etiology of both the disease and antibodies is unknown. Furthermore, since many autoantigens reside in the nucleus and are, therefore, presumably inaccessible to autoantibodies, it is also unclear to what extent the antibodies contribute to the pathogenesis, especially in the initial stages of the autoimmune disease.Several models have been proposed to account for the etiology and pathogenesis of autoimmune disease. One of these, the molecular mimicry model (2), states that an infecting agent such as a bacteria or virus might be involved in the onset or pathology of the disease. Antibodies produced against the infecting agent might cross-react with cellular antigens and, potentially, contribute to the disease state.Recently, efforts have been directed toward mapping epitopes recognized by antibodies isolated from patients with different types of autoimmune diseases. Thus far, epitopes have been mapped for a variety of different autoantigens, and some of these are similar to viral sequences (3-6). For example, autoepitopes have been mapped on the a subunit of the acetylcholine receptor that is associated with myasthenia gravis (3) and on the diffuse systemic sclerosis antigen DNA topoisomerase I (4). The a subunit of acetylcholine receptor exhibits immunological cross-reactivity with a homologous domain on herpes simplex virus glycoprotein D (3), while the antigenic 11-amino acid region of DNA topoisomerase I contains a 6-amino acid sequence that is identical to a sequence present in the group-specific antigen (p309ag) of some mammalian retroviruses (4). However, the usefulness of these studies is limited because in most instances mapping was doneThe publication cost...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

Xie

Snyder

1995

Proc. Natl. Acad. Sci. U.S.A.

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“…They also have decreased EBVspecific T-cell cytotoxicity [55] which accounts for the impaired ability to abort in-vitro outgrowth in regression assays of EBV-induced B-cell transformation [54,55]. Decreased EBV-specific T-cell cytotoxicity might be explained by the reported decrease in MHC class I expression on B cells of patients with Sjögren's syndrome [37].…”

Section: Sjögren's Syndromementioning

confidence: 99%

Epstein-Barr Virus and Autoimmunity

Pender¹

2004

Infection and Autoimmunity

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“…There is increasing evidence suggesting that EBV infection may be related to lacrimal gland lymphocytic proliferation of Sjögren syndrome, which leads to decreased aqueous tear production and severe DED (40,41) . Many studies have reported primary Sjögren syndrome development immediately after serological confirmation of infectious mononucleosis (42)(43)(44) .…”

Section: Hepatitis Cmentioning

confidence: 99%

Dry eye disease caused by viral infection: review

Alves¹,

Angerami²,

Rocha³

2013

Arq. Bras. Oftalmol.

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Dry eye disease and ocular surface disorders may be caused or worsened by viral agents. There are several known and suspected virus associated to ocular surface diseases. The possible pathogenic mechanisms for virus-related dry eye disease are presented herein. This review serves to reinforce the importance of ophthalmologists as one of the healthcare professional able to diagnose a potentially large number of infected patients with high prevalent viral agents. Keywords

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Primary Sjögren's Syndrome After Infectious Mononucleosis

Cited by 79 publications

References 14 publications

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

Epstein-Barr Virus and Autoimmunity

Dry eye disease caused by viral infection: review

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