Primary Sjögren's syndrome in children: Is a family approach indicated?

Longhi, Bárbara Sugui; Appenzeller, Simone; Centeville, Maraísa; Gusmão, Reinaldo Jordão; Marini, Roberto

doi:10.1590/s1807-59322011001100023

Cited by 20 publications

(22 citation statements)

References 18 publications

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“…Further support comes from Singer et al [7], who suggest that parotitis may be the most common glandular manifestation seen in pediatric primary SS, with other reports citing an occurrence of up to 75% of cases. Longhi et al [8] also support this conclusion and argue that recurrent parotitis should be included as a diagnostic factor for juvenile SS. Alp et al [9] reported on a child diagnosed with primary SS who presented with 15 episodes of parotid swelling over the course of 4 years, with each episode lasting 1-2 weeks, supporting the idea that recurrent parotitis may be indicative of SS.…”

Section: Clinical Manifestationsmentioning

confidence: 83%

“…According to the Revised International Classification Criteria for Sjögren's Syndrome from the American-European Consensus Group, primary SS can be diagnosed in adults if four of the following six criteria are present: presence of ocular symptoms, presence of oral symptoms, evidence of keratoconjunctivitis sicca, focal sialadenitis upon minor salivary gland biopsy, instrumental evidence of salivary gland involvement and presence of SSA or SSB antibodies [8]. This criteria, however, often does not provide an accurate diagnosis for juvenile SS since the symptoms seen in juvenile SS vary.…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Literature review: the prevalence and indicators of sjögren's syndrome in juveniles

Smolik¹,

Taylor²,

Wilson³

et al. 2017

Oral Health Care

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Sjögren's Syndrome (SS), a chronic auto-immune disorder most frequently diagnosed in women over the age of 40, is becoming progressively more evident in juvenile patients. Coupled with the fact that there is no set diagnostic criteria for diagnosing SS in the pediatric population and the finding that SS manifests differently in pediatric and juvenile patients than in adults, diagnosis in younger patients is often difficult. This review seeks to address this situation by examining proposed diagnostic criteria, advances made in identifying diagnostic markers for juvenile Sjögren's Syndrome, and viable treatment methods for both primary and secondary SS. Although a wide spectrum of possible manifestations of juvenile SS as well as its low prevalence may complicate research studies, the knowledge gained will serve to better organize future research while assisting clinicians and benefiting patients.

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Section: Clinical Manifestationsmentioning

confidence: 83%

Section: Diagnosismentioning

confidence: 99%

Literature review: the prevalence and indicators of sjögren's syndrome in juveniles

Smolik¹,

Taylor²,

Wilson³

et al. 2017

Oral Health Care

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show abstract

“…Barbara S. et al presentan en 2011 el caso de tres pacientes (una madre y sus dos hijas), en el cual se pone de manifiesto la necesidad de realizar criterios diagnósticos diferentes por grupo etario y de agregarle mayor importancia al factor genético; esto es congruente con reportes hechos en los últimos 20 años de la asociación familiar 24 , y en este caso, el aspecto de mayor relevancia, porque el antecedente de SS en la madre y hermana fue lo que llevó a sospechar enfermedad reumatológica en el paciente.…”

Section: Discussionunclassified

Síndrome de Sjögren en un adolescente. Caso Clínico

Ossa¹

2021

Rev. méd. Chile

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“…Familial Sjögren's syndrome has been well described [34,35]. However, in English literature there are no reports of Sjögren's syndrome presenting as RTA in siblings.…”

Section: Discussionmentioning

confidence: 99%

Renal Tubular Acidosis in Sjögren's Syndrome: A Case Series

2014

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Background: The exact frequency of distal and proximal renal tubular acidosis (RTA) in Sjögren's syndrome is unknown. Other features of Sjögren's syndrome like polyuria, glomerular manifestations, familial occurrence and pregnancy are not widely reported. The aim was to prospectively study the clinical features and outcome of distal and proximal RTA in Sjögren's syndrome and also report on other renal manifestations of Sjögren's syndrome. Methods: The present study is a prospective consecutive case series of patients who presented with a history suggestive of RTA and Sjögren's syndrome. All patients were followed for 1 year. The diagnosis of RTA was by fractional excretion of bicarbonate. The diagnosis of Sjögren's syndrome was according to the American-European classification system [modified by Tzioufas and Voulgarelis: Best Pract Res Clin Rheumatol 2007;21:989-1010]. Results: The total number of RTA patients diagnosed during this period was 149. Sjögren's syndrome accounted for 34.8% (52 of 149) of RTA patients. The important symptoms and laboratory parameters were oral and ocular symptoms in 23 (44.2%), dental caries in 12 (23%), body pains in 47 (90.3%), mean serum pH 7.202 ± 0.03, mean serum bicarbonate, 14.03 ± 1.66 mmol/l, and mean urine pH, 7.125 ± 0.54. There were 30 (57.6%) patients with distal RTA and 22 (42.3%) patients with proximal RTA. Conclusions: The clinical implication of the present study is that RTA is a common feature of Sjögren's syndrome. It may be missed if the presentation is not due to oral and ocular symptoms. The present study is also the only one with a 1-year follow-up.

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Primary Sjögren's syndrome in children: Is a family approach indicated?

Cited by 20 publications

References 18 publications

Literature review: the prevalence and indicators of sjögren's syndrome in juveniles

Literature review: the prevalence and indicators of sjögren's syndrome in juveniles

Síndrome de Sjögren en un adolescente. Caso Clínico

Renal Tubular Acidosis in Sjögren's Syndrome: A Case Series

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