Primary Small-Bowel Malignancy: Update in Tumor Biology, Markers, and Management Strategies

Abstract

Recent advances in molecular characterization holds promise in novel targeted therapies. Currently ongoing trials are exploring efficacy of targeted therapies and role of adjuvant therapy for adenocarcinoma and results are awaited. Early detection and aggressive surgical therapy for all localized tumors and lymph node sampling particularly for adenocarcinoma remains the main treatment modality.

Rare Coexistance of Ileal Diverticulosis, Crohn’s Disease and Small Bowel Adenocarcinoma: Report of a Case

“…This apparent "neoplastic resistance" finds its eventual explanation in the low bacterial content capable of transforming food components into carcinogens, along with the large amount of alkaline fluid secretion, the rapid transit time, and the high concentration of the enzyme benzopyrene hydroxylase, which reduce the mucosal contact with potential carcinogens (8). The mean age of diagnosis of small bowel tumors is 60 years of age, with a slight male preponderance.…”

Small bowel sarcoma: Tumor biology and advances in therapeutics

“…GIST arises from interstitial cells of Cajal, while leiomyosarcoma arises from denovo mutations in the smooth muscles of the gastrointestinal tract [3].…”

“…In humans it is localized in chromosome 11q13 and is identified as calcium dependent, receptor activated chloride channel protein [10]. Together KIT and DOG1 confirm nearly 100% of sporadic GIST and is the standard IHC tests used to diagnose GIST [3,10].…”

“…Actin binding proteins such as calponin and h-caldesmon are more specific myogenic markers [3]. Smoothelin is another novel marker for differentiated contractile smooth muscle cells and is not expressed in myofibroblasts or striated muscle cells [2].…”

Akut karın ağrısında nadir bir sebep: ince bağırsak adenokarsinomu

“…Tahmini yıllık insidansı 2.1/100.000'dir (1). İnce bağırsağın primer malignitelerinde 40' dan fazla histopatolojik neoplasm türü tanımlanmış olmakla birlikte %95' ini adenokarsinomlar, gastrointestinal stromal tümörler, karsinoidler ve lenfomalar oluşturmaktadır.…”