Primary small bowel melanoma. A case report and a review of the literature

Spiridakis, K

doi:10.11138/gchir/2015.36.3.128

Cited by 16 publications

(28 citation statements)

References 26 publications

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“…Although small bowel does not contain melanocytes, these cells have been found in the alimentary tract occasionally, thus supporting the theory of primary lesion in these sites [ 12 ]. Furthermore, a second theory suggests that malignant melanoma develops from intestinal Schwann cells, even if this theory is not confirmed [ 12 ]. Finally, a third theory suggests that malignant melanomas originate from the neural crest, and these potential cells migrate via the umbilical-mesenteric canal and later differentiate into specialized cells, i.e.…”

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

“…There are different theories for the origin of malignant melanomas in the small bowel [ 12 ]. Although small bowel does not contain melanocytes, these cells have been found in the alimentary tract occasionally, thus supporting the theory of primary lesion in these sites [ 12 ]. Furthermore, a second theory suggests that malignant melanoma develops from intestinal Schwann cells, even if this theory is not confirmed [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, a third theory suggests that malignant melanomas originate from the neural crest, and these potential cells migrate via the umbilical-mesenteric canal and later differentiate into specialized cells, i.e. amine precursors uptake and decarboxylation (APUD) cells, which undergo neoplastic transformation [ 12 ]. According to this theory (APUD theory), ileum, representing the distal end of the umbilical mesenteric canal, should be the commonest site of primary malignant melanoma of the small intestine [ 12 - 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Ileal Melanoma, A Rare Cause of Small Bowel Obstruction: Report of a Case, and Short Literature Review

Sinagra

Sciumè

2020

CRP

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Background: Malignant melanoma frequently spreads to the gastrointestinal tract, with 60% of patients with advanced metastatic disease showing digestive involvement; however, primary MM of the small intestine is a controversial diagnosis. In fact, whether these lesions arise as true small bowel primary neoplasms or represent metastases from unidentified cutaneous melanomas remains debatable. The most common complications are intestinal obstruction, massive gastrointestinal bleeding, and perforation. Objective & Methods: We report a case of a 64-year-old patient, with an unremarkable medical history, in which a late diagnosis of primary ileal malignant melanoma in the setting of an emergency laparotomy due to small bowel obstruction, and where PET-scan showed costal metastasis. Therefore, we provide a narrative review of the scientific literature about this topic. Results: 36 cases of primary small bowel melanoma, included that in the present study, were found through our search in the scientific literature. Conclusion: Primary small bowel MM appears to be an extremely rare entity which clinicians should be more aware of, in order to plan better a correct strategy of early diagnosis and appropriate treatment.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ileal Melanoma, A Rare Cause of Small Bowel Obstruction: Report of a Case, and Short Literature Review

Sinagra

Sciumè

2020

CRP

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“…In some patients with mucosal melanoma metastasis, it is difficult to identify a precedent or a coexistent primary lesion [8]. The criteria for diagnosing primary melanoma include the absence of another site of primary melanoma and the absence of previous history of removing either melanoma or atypical melanocytic nevi in the skin, retina, anal canal, or occasionally in other locations such as esophagus, penis, and vagina [10].…”

Section: Discussionmentioning

confidence: 99%

Distal Jejunal Intussusception from Melanoma Metastasis: Case Report

Gatelli¹,

Gatelli²,

Arendt³

et al. 2018

JPP

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Introduction: The invagination of one intestinal loop within another rarely occurs in adults and it is usually caused by a polyp or another intraluminal lesion. Intussusceptions occur mostly in children; an organic lesion is not necessary, and colic pain syndrome, rectal bleeding, and a palpable mass (the intussuscepted segment) are characteristics. Justification: To compare data from a tertiary reference hospital with data described in the literature, considering the evolution of such patients is unknown in our field. Objective: To report the case of a patient with distal jejunal intussusception from melanoma metastasis. Method: Information was obtained through medical record reviews, patient interviews, photographic records of the diagnostic methods and the surgery to which patients were subjected, and literature review. Final considerations: The case reported and the publications surveyed bring to light the discussion on the therapeutics of the complex condition that is melanoma metastasis, showing that some patients may present satisfactory and lasting results regarding symptom relief and improvement of quality of life.

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