Primary small cell carcinoma of the breast: a case report

Dalle, Iman Abou; Abbas, Jaber; Boulos, Fouad; Salem, Ziad; Assi, Hazem

doi:10.1186/s13256-017-1467-0

Cited by 27 publications

(32 citation statements)

References 24 publications

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“…Small cell carcinoma, whether the primary site is the breast or any other site of the body, the histopathologic features and immunohistochemical findings are the same. Therefore, to diagnose a primary breast small cell carcinoma we need to exclude if there is any other primary cancer outside the breast with the help of imaging studies, neuroendocrine differentiation not less than 50%, and/or presence of in situ carcinoma component histologically [ 4 ]. A case reported by Adegbola et al [ 1 ] exhibited foci of an in situ component of neuroendocrine pattern which confirms the primary breast origin.…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal markers (ER or PR) were positive in 35–54% of cases and HER2-neu was almost always negative [ 9 ]. The case reported by Abou Dalle et al [ 4 ] was receiving tamoxifen since progesterone receptor was positive in 20% of the tumor cells. Her2-neu, PR, and ER were negative in our case.…”

Section: Discussionmentioning

confidence: 99%

“…The second criterion is by excluding any primary cancer site in the body other than the breast by the use of imaging techniques other than mammography. The third method of diagnosis is by histopathologic testing of the breast when it shows carcinoma in situ [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report

et al. 2021

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Patient: Female, 39-year-old Final Diagnosis: Primary neuroendocrine small cell carcinoma of the breast Symptoms: Left breast mass • recurrent mastitis Medication: — Clinical Procedure: — Specialty: Pathology • Radiology Objective: Rare disease Background: Primary breast small cell neuroendocrine carcinoma is a rare subtype of breast cancer with about 57 cases reported in the literature. This rare type of cancer represents about 0.1% of breast carcinomas. Recently, the World Health Organization defined this type of cancer as a separate entity from other breast cancer types. The diagnosis of this type of cancer in the breast is difficult because the histological pattern is similar to the small cell neuroendocrine carcinoma of other more common primary sites of origin, including the lung. Case Report: A 39-year-old woman presented to our hospital with a left breast mass and recurrent mastitis. Physical examination revealed a painless lump in her left breast with a brown-colored discharge from the nipple, and her child refused breastfeeding from the left breast. A high-density well-defined rounded mass was observed upon mammography in the upper lateral aspect of the left breast. This mass lesion appeared hypoechoic with no posterior acoustic shadowing on ultrasound scan. A core-needle biopsy of the mass was performed and the diagnosis of small cell neuroendocrine carcinoma was rendered after histopathologic examination. Positron emission tomography scanning was helpful in the exclusion of primary origin from other organ sites; thus, the primary breast origin of the tumor was confirmed. Conclusions: This case report provides a comprehensive approach to diagnose this type of small cell carcinoma originating primarily in the breast. The suspicion of this type of breast cancer should be raised if there is presence of characteristic histopathologic findings with the exclusion of any primary origin from other organ sites by the help of imaging studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report

et al. 2021

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“…It is high time that a well-researched, objectively proven guidelines for treatment of this rare entity is placed on record. Yet the best management algorithm is still an enigma and prognosis for PSCNET breast is not established [1,10].…”

Section: Discussionmentioning

confidence: 99%

“…Breast cancer is the leading cause of cancerrelated death in women. With an incidence of <1%, primary small cell neuroendocrine tumors (PSCNET) of breast, are a rare entity, amongst all breast malignancies [1,2]. First described in 1983, by Wade et al, there are fewer than hundred cases reported in medical literature [3].…”

Section: Introductionmentioning

confidence: 99%

Primary Small Cell Neuroendocrine Tumor of Breast: A Mammary Gland Enigma

Sharma¹,

Mehra²,

Singh³

et al. 2019

JCR

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Background: Primary small cell neuroendocrine tumor of the breast is a rare form of tumor with very few reported cases in the medical literature. The rarity of the disease has produced a lacuna in the management algorithms of the disease. Most of the times extrapolation of management protocols of small cell carcinoma lung is employed. Case Report: We report here a primary small cell neuroendocrine tumor of the breast in a post-menopausal lady. The diagnosis was reached by DOTA-NOC scan, considered highly specific for neuroendocrine tumors and post-operative histopathological examination. Conclusion: Breast is an extremely rare site for primary small cell carcinoma. Management protocols in existence are yet to be standardized.

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