Primary small cell carcinoma of the larynx. Survival time of 47 months. Case report

Abstract

Small cell carcinoma (SCC) of the larynx is a rare type of neuroendocrine carcinoma (NEC), few cases of which have been described in the literature. The prognosis for this type of carcinoma is poor, with a survival time typically not exceeding two years. We describe the case of a 54-year-old male patient with a primary tumor in the right ventricular band and a biopsy compatible with SCC. The patient underwent radiotherapy (RT) and concomitant chemotherapy (QT) and, after a relapse at 17 months, underwent total laryngectomy with bilateral neck dissection. The survival time was 47 months. Further studies are required to elucidate the possible causes of the better prognosis in some cases.

Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report

“…Raposo et al. published a report of a patient with laryngeal SCC treated with radiotherapy and chemotherapy (cisplatin, etoposide), who experienced recurrence and required additional cycles of treatment, together with laryngectomy, and survived for 47 months ( 27 ). Iqbal and colleagues published a case series of 9 patients with laryngeal small cell neuroendocrine cancers, among whom one patient survived for 99 months ( 28 ).…”