Primary somatosensory evoked magnetic fields elicited by sacral surface electrical stimulation

Matsushita, Mabumi; Nakasato, Nobukazu; Nakagawa, Haruo; Kanno, Akira; Kaiho, Yasuhiro; Arai, Yoichi

doi:10.1016/j.neulet.2007.11.025

Cited by 10 publications

(5 citation statements)

References 22 publications

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“…Fifteen hertz stimulation results in an inter-stimulus interval of 67 ms between consecutive stimuli and this may somehow be optimal for cortical excitation. The average afferent latency response when using sacral surface electrical stimulation is 20-30 ms 23 and we would predict a similar response will be found from stimulating over S2/S3 with MS which would feasibly allow the afferent response to reach the cortex followed closely by subsequent stimuli potentially evoking LTP like excitation in the motor cortex. Why this degree of excitation was not observed at 5 Hz may be explained by the longer inter-stimulus interval of 200 ms allowing for a degree of cortical recovery preceding subsequent stimuli.…”

Section: Discussionmentioning

confidence: 67%

Rapid rate magnetic stimulation of human sacral nerve roots alters excitability within the cortico‐anal pathway

Harris

Singh

Rothwell

et al. 2008

Neurogastroenterology Motil

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Sacral nerve root stimulation (SNS) can produce dramatic symptomatic improvement in faecal incontinence (FI). However, the physiological mechanism behind this improvement remains unknown. One hypothesis is that SNS may modulate cortico-anal pathways and drive compensatory changes within the spinal cord or cerebral cortex that beneficially alter sphincter function. Our aim was to assess whether short-term experimental SNS can induce changes in the human cortico-anal pathway. Eight healthy volunteers (mean age 30 years) were studied. Subjects were investigated on three separate occasions and randomized to either active (5 and 15 Hz) or sham rapid-rate lumbosacral magnetic stimulation (rLSMS). Anal sphincter electromyograms (EMG) were recorded from an anal probe following single-pulse transcranial magnetic stimulation, at baseline, immediately, 30 and 60 min following rLSMS at either (i) 5 Hz for 15 min, (ii) 15 Hz for 15 min or (iii) sham stimulation for 15 min. In addition, manometry and anal sphincter sensation was measured in a subset of subjects. Interventions were compared to sham using anova. Fifteen hertz rLSMS increased cortico-anal EMG response amplitude in the 1 h postintervention (F(4, 28) = 3.2, P = 0.027), without a shift in response latency. This effect was not demonstrated with either 5 Hz or sham stimulation. rLSMS had no short-term effect on sensation or physiology. Short-term magnetic stimulation of the sacral nerve roots induces changes in cortico-anal excitability which is frequency specific. These data support the hypothesis that SNS produces some of its beneficial effect in patients with FI by altering the excitability of the cortico-anal pathway.

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Section: Discussionmentioning

confidence: 67%

Rapid rate magnetic stimulation of human sacral nerve roots alters excitability within the cortico‐anal pathway

Harris

Singh

Rothwell

et al. 2008

Neurogastroenterology Motil

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“…Bladder afferent information is transmitted to the parietal sensory cortex in humans. 26 However, it remains unclear whether a parietal lesion causes bladder dysfunction in humans. Just two studies have thus far reported this association, and the authors of those studies hypothesized that parietal lobe infarction might cause the following: (i) impaired bladder sensation during filling; and (ii) hypoactive detrusor muscle during micturition.…”

Section: Discussionmentioning

confidence: 99%

Relationships between overactive bladder and cerebral white matter hyperintensity in outpatients at a memory clinic

Komiya

Umegaki

Ogama

et al. 2021

Geriatrics Gerontology Int

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Aim: Cerebral small vessel disease and lower urinary tract symptoms are common in older people. However, the association between white matter hyperintensity (WMH) and overactive bladder (OAB) is not fully understood. We aimed to identify the relationship between WMH and OAB.Methods: We carried out neuropsychological testing and head magnetic resonance imaging (T2-weighted and fluid-attenuated inversion recovery) of 72 outpatients at a memory clinic and evaluated their Overactive Bladder Symptom Score. WMH was assessed using the Fazekas scale, and WMH volumes were determined using Software for Neuro-Image Processing in Experimental Research. OAB was diagnosed based on a urinary urgency score (the third question of the Overactive Bladder Symptom Score) of two or higher and a total Overactive Bladder Symptom Score of three or higher. Multivariate logistic analysis was carried out, with the presence/absence of overactive bladder as the outcome variable, and age, sex, body mass index and diabetes mellitus as covariates.Results: Of the 72 participants, 17 (24%) were diagnosed with OAB. WMH assessed by the visual rating scale was not associated with OAB. However, participants with OAB showed significantly higher WMH volume than those without OAB. Regionally, participants with OAB showed high WMH volume in the frontal, occipital and parietal lobes. Multiple logistic regression analysis showed that WMH was significantly associated with OAB (OR 1.82, 95% CI 1.11-2.98), after adjustment for clinically important confounders.Conclusions: Cerebral WMH volume is associated with OAB, independent of age, sex, body mass index and diabetes mellitus.

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“…Three-dimensional (3D) anatomical images were obtained with a 3.0 T MRI (Signa 3.0T; General Electric Medical System, Milwaukee, WI, USA) using three fiducial markers formed by small oil-containing capsules as outer landmarks. 14 All SEFs were filtered from 0.1 Hz to 260.4 Hz and digitized at 1001.5 Hz. Data from À100 ms to 300 ms were recorded for each stimulus.…”

Section: Methodsmentioning

confidence: 99%

Evoked magnetic fields as a tool to optimize therapeutic electrical stimulation of the sacral surface

Matsushita

Nakasato

Nakagawa

et al. 2009

Journal of Clinical Neuroscience

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Primary somatosensory evoked magnetic fields elicited by sacral surface electrical stimulation

Cited by 10 publications

References 22 publications

Rapid rate magnetic stimulation of human sacral nerve roots alters excitability within the cortico‐anal pathway

Rapid rate magnetic stimulation of human sacral nerve roots alters excitability within the cortico‐anal pathway

Relationships between overactive bladder and cerebral white matter hyperintensity in outpatients at a memory clinic

Evoked magnetic fields as a tool to optimize therapeutic electrical stimulation of the sacral surface

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