Primary spinal intradural extramedullary lymphoma: A novel management strategy

Sao-Mai, Angelique; Smith, Gabriel A.; Pace, Jonathan; Hdeib, Alia; Kasliwal, Manish K.

doi:10.1016/j.jocn.2016.10.033

Cited by 6 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spinal lymphoma responds very well to radiation treatment alone. 18,19 The combined chemo-radiation, including intrathecal cytarabine and methotrexate, showed a better outcome and long-term survival. 12 The patient was put on chemo-radiation, CHOP plus intrathecal cytarabine, methotrexate and radiation following decompression surgery and histopathologic diagnosis of the lesion.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Intradural Extramedullary Spinal Burkitt’s Lymphoma: A Case Report

Sereke

Bongomin

Muyinda

2020

IMCRJ

View full text Add to dashboard Cite

Background: Non-Hodgkin's lymphoma (NHL) rarely involves the spine primarily, and if it does, is almost always associated with advanced disease. Case Presentation: An 8-year-old male presented with a one month history of nuchal pain followed by stiffness and rapidly progressive upper and lower limb weakness. He was seronegative for HIV and EBV. Computed tomography myelogram and magnetic resonance imaging of the cervical and thoracic spine showed a long segment (C2 to T1) complete absence of cerebrospinal fluid signal and mildly enhancing intradural extramedullary lesion with an extradural and right paravertebral muscle extension, respectively. Post-excision biopsy histopathology and immunohistochemistry confirmed the diagnosis of a CD 10+, CD20+, CD45+, Bcl-2+, Ki67+, and EBER in situ hybridization for EBV negative, Burkitt's lymphoma (BL). Cytogenetic analysis showed chromosomal translocations of 8q24. CHOP plus intrathecal cytarabine, methotrexate was given as chemotherapy regimen. 1.8 grays (Gy) per fraction to the local area for an average total dose of 36 Gy was given with a resultant significant clinical improvement. Conclusion:Though considered uncommon spinal canal tumors, BL should be in the differential diagnosis, if multilevel involvement is demonstrated on imaging.

show abstract

Section: Discussionmentioning

confidence: 99%

“…All patients with primary spinal extramedullary lymphoma reported in the literature underwent surgery, which was similar to our patient's initial management to decompress the spinal stenosis. 17,18 The patient was first treated by surgical decompression of the spinal cord stenosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Intradural Extramedullary Spinal Burkitt’s Lymphoma: A Case Report

Sereke

Bongomin

Muyinda

2020

IMCRJ

View full text Add to dashboard Cite

show abstract

“…Secondary spinal lymphomas are more frequent than primary lymphomas [ 2 ]. Intraspinal location of non-Hodgkin lymphoma usually occurs in the extradural space, where it can be diagnosed in 0.1%–6.5% of patients with non-Hodgkin lymphomas [ 2 3 ].…”

Section: Commentmentioning

confidence: 99%

Spinal Non-Hodgkin Lymphoma Mimicking Epidural Hematoma

Vangeel

Bleyen

Cocker

2022

Journal of the Belgian Society of Radiology

View full text Add to dashboard Cite

A patient, recently diagnosed with non-Hodgkin lymphoma, presented with acute tetraplegia after surgical cervical lymph node biopsy. MRI of the cervical spine demonstrated an epidural space-occupying lesion with compressive myelopathy. While epidural hematoma was the tentative diagnosis, intra-operatively non-Hodgkin lymphoma was found. Several factors may have accounted for the inaccurate interpretation of the MRI: the acute clinical presentation appearing shortly after surgery, the non-specific signal intensities of (hyper-) acute hematomas, the lack of contrast-enhanced images, and the absence of the FDG-avid spinal mass in the PET/CT-report. Without radiological features of invasiveness and contrast-enhanced images, careful interpretation is mandatory for space-occupying epidural lesions.Teaching Point: Caution is needed when interpreting an epidural space-occupying lesion in the absence of contrast-enhanced images.

show abstract