Primary Squamous Cell Carcinoma Arising From a Breast Implant Capsule: A Case Report and Review of the Literature

Buchanan, Patrick J.; Chopra, Vinod K; Walker, Kristen; Rudolph, Ray; Greco, Richard J.

doi:10.1093/asj/sjy092

Cited by 30 publications

(65 citation statements)

References 14 publications

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“…Primary SCC of the breast is a rare tumour, accounting for an estimated frequency of 0.1-3.6% of all invasive breast cancers with poor clinical outcomes [9][10][11]. Skin or nipple cancer and metastasis sites should be excluded when SCC is diagnosed [12].…”

Section: Discussionmentioning

confidence: 99%

Breast prosthetic implant-associated Squamous Cell Carcinoma: A case report and Literature Review

Liu

Zhao

et al. 2021

Preprint

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BackgroundBreast reconstruction is widely used for women undergoing mastectomy. Prosthetic implants have become a common technique performed for these women because of their safety, flexibility and adjustable size. There are few reports of implant-associated squamous cell carcinoma. In addition to this report, only 8 reports including 11 cases have been reported in the English literature.Case presentationWe report the case of a patient with breast prosthetic implant-associated squamous cell carcinoma who received mastectomy and prosthetic implants 10 years ago. She was recently hospitalized with unilateral breast enlargement. Surgical pathology showed squamous cell carcinoma around the breast implant. There was no evidence of primary squamous cell carcinoma at any other anatomic site. We analysed all 11 patients with breast implant-derived squamous cell carcinoma (SCC) from a thorough literature search to identify studies. The median age of patients at SCC diagnosis was 56.8 years old. The average time from initial breast augmentation until SCC diagnosis was 21.9 years. The prognosis was poor; 4 of the 11 patients eventually progressed or died within 1 year, 3 of the 11 patients were disease free during the follow-up period, and 4 of the 11 patients were lost to follow-up. The most widespread opinion is that chronic inflammation from breast implants plays a substantial role in the disease progression of SCC.ConclusionsWe reported the rare complications associated with breast prosthetic implants and reviewed the literature. This malignancy should be taken into account in patients with breast prosthetic implants who have acute breast pain and enlargement.

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Section: Discussionmentioning

confidence: 99%

Breast prosthetic implant-associated Squamous Cell Carcinoma: A case report and Literature Review

Liu

Zhao

et al. 2021

Preprint

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“…Graziano et al (12) reported that IDC of the breast could progress to metaplastic SCC after induction chemotherapy. Previous research revealed that long-standing breast implants and acute unilateral breast pain and enlargement might also cause secondary PSCC of the breast (13,14). Furthermore, PSCC of the breast possibly arises from previous radiation (15).…”

Section: Discussionmentioning

confidence: 99%

Change of Pathological Type to Metaplastic Squamous Cell Carcinoma of the Breast During Disease Recurrence: Case Report and Literature Review

Guo

Chen

et al. 2020

Front. Oncol.

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Background: Metaplastic squamous cell carcinoma (SCC) of the breast is a rare and heterogeneous group of primary breast malignancies. The etiology, pathogenesis, and proper treatment for this kind rare breast cancer are still unclear. Case presentation: We reported a case of a 55-year-old woman with a palpable lump in the inner quadrant of the right breast. She underwent a right breast mass resection and sentinel lymph node biopsy, which revealed that the tumor was an invasive ductal carcinoma, followed by four cycles of doxorubicin plus cyclophosphamide and four cycles of docetaxel as adjuvant chemotherapy, and then simultaneous integrated boost intensity modulated radiotherapy to the whole right breast. After 2 years' follow-up, she had biopsy-proven disease recurrence in the right breast, which revealed SCC, and a mammogram showed abnormalities in the lower inner quadrant of the right breast and left axillary lymph nodes. Then we performed bilateral breast modified radical mastectomy, which confirmed that the recurrent tumors were metaplastic SCC, followed by adjuvant chemotherapy and adjuvant radiotherapy of the left supraclavicular and apical axillary regions. There has been no recurrent or metastatic evidence in the 16 months' follow-up since the second surgery. Conclusion: This case report shows that evolution of pathology type in recurrent breast cancer after initial treatment is possible. Detailed pathologic and immunohistochemical analyses are needed for identification of this change. Surgery and adjuvant radiation and chemotherapy are appropriate treatments for recurrent primary SCC of the breast.

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“…The last case described by Buchanan et al 10 was a 65-year-old woman with a remote history of breast augmentation using foam-covered silicone implants. Again, these cases lend support to the theory that the presence of chronic inflammation results in metaplasia and finally the development of squamous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…If it is of squamous origin, keratinized squamous cells can be observed in the histological study of the sample. 10 , 24 …”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma as a Result of Likely Industrial Grade Ruptured Poly Implant Prosthèse Silicone Buttock Implants

Camacho

Obaíd

Bustos

et al. 2020

Aesthetic Surgery Journal Open Forum

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The Poly Implant Prosthèse (PIP) implants were withdrawn from the market in 2010 due to the use of a nonmedical grade silicone filler. In 2012, the French medical authorities and the International Confederation of Societies of Plastic, Reconstructive and Aesthetic Surgery recommended the extraction of PIP implants. However, during the duration of this scandal, each country in the world did not agree with a uniform procedure, and this rule was not implemented in its entirety. Although laboratory test results on PIP implants were negative for cytotoxicity and genotoxicity, there are many reports in the literature of several complications associated with PIP implants, including high rupture rates and the fact that they are 3 to 5 times more likely to produce local tissue reactions. On the other hand, the development of more strange and worse prognosis complications, such as the development of squamous carcinoma associated with the use of silicone implants (not necessarily related to PIP implants), is less known. To date, only 6 cases have been reported, and all are related to breast augmentation. The authors made the first report of primary gluteal squamous cell cancer related to rupture and delayed removal of PIP silicone buttock implants. Level of Evidence: 5

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Primary Squamous Cell Carcinoma Arising From a Breast Implant Capsule: A Case Report and Review of the Literature

Cited by 30 publications

References 14 publications

Breast prosthetic implant-associated Squamous Cell Carcinoma: A case report and Literature Review

Breast prosthetic implant-associated Squamous Cell Carcinoma: A case report and Literature Review

Change of Pathological Type to Metaplastic Squamous Cell Carcinoma of the Breast During Disease Recurrence: Case Report and Literature Review

Squamous Cell Carcinoma as a Result of Likely Industrial Grade Ruptured Poly Implant Prosthèse Silicone Buttock Implants

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