Primary squamous cell carcinoma of the breast

Toikkanen, Sakari

doi:10.1002/1097-0142(19811001)48:7<1629::aid-cncr2820480726>3.0.co;2-#

Cited by 82 publications

(63 citation statements)

References 13 publications

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“…In the multiparous cohort of double CDK4(R24C);myrp110a, we found a mix of tumors with and without a squamous component. A squamous component is rarely observed in malignant human breast cancer but the mammary epithelium of older mice under chronic prolactin stimulation commonly has squamous metaplasias (39). In human breast tumors, activation of cyclin D1 is a common event.…”

Section: Discussionmentioning

confidence: 99%

Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110α Predisposes Mammary Glands to Neoplastic Transformation

et al. 2008

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Phosphatidylinositol 3-kinases (PI3K) constitute important regulators of various signaling pathways with relevance in cancer. Enhanced activation of p110A, the catalytic subunit of PI3K, was found in a high proportion of many human tumor types. We generated a mouse model in which PI3K is activated by forced recruitment of p110A to the membrane. Different transgenic lines expressing myristoylated p110A protein under the control of the epithelial-specific mouse mammary tumor virus promoter were selected according to different levels of PI3K activity and characterized. Delayed mammary gland involution and morphologic changes of the mammary ducts could be detected in young transgenic female mice. These changes were more pronounced in old animals, especially in mutiparous females, in which we observed increased ductal branching, alveolar hyperplasia, and intraductal neoplasia. We also observed a small percentage of mammary tumors. Crosses of myrp110A transgenic mice with heterozygous p53(+/À) knockout mice resulted in neither enhanced tumorigenesis nor in a stronger mammary gland phenotype. However, the CDK4 activating mutation (R24C) lead to increased tumorigenesis in transgenic myrp110A mice, emphasizing the postulated perturbation of the interaction of the CDK4/Rb/E2F cascade and the PI3K signaling in many human cancers. Interestingly, in tumors of myrp110A transgenic mice, we observed an increased phosphorylation of the estrogen receptor-A, a typical feature of human breast cancer. The model presented here will help to discover additional factors which influence the progression of preneoplastic lesions to tumors in the mammary gland and to explore antitumor therapies based on PI3K or estrogen receptor-A pathway inhibition. [Cancer Res 2008;68(23):9643-53]

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Section: Discussionmentioning

confidence: 99%

Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110α Predisposes Mammary Glands to Neoplastic Transformation

et al. 2008

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“…Proportion of breast cancers 0.1% [1][2][3] 0.4% [4,5] 0.1 %-0.6% [1,6,7] 0.2%-0.6% [1,[8][9][10] Ͻ0.1% [11][12][13] 0.7% [1,14,15] 0.15% [16] Male incidence Case reports [2,[17][18][19] with aggressive disease in two cases [2,19], an unremarkable clinical course in a third [18], and limited data in a series [17] No male cases noted Rare male cases have been reported [20] No male cases noted Only female cases [21] 3.5% of cases are male [22] 0.2% of male breast cancers [23]; occurs in both genders in children, but more common in girls [24,25] Age, yrs Median, 58-66 [2,3,17,26,27] Mean, 52-61 [4,28,29] Median, 54-63 [1 ,6] Median, 47-61 [1, 8-10, 30- [48,49] May arise from preexisting benign apocrine epithelium [50]; microscopically cells have abundant foamy to granular eosinophilic cytoplasm and round nuclei with prominent nucleoli …”

Section: Secretory Breast Cancermentioning

confidence: 99%

Management of Unusual Histological Types of Breast Cancer

et al. 2012

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There is increased understanding of the heterogeneity of breast tumors, with greater emphasis now being placed on histological and molecular profiles and, in particular, their implications for prognosis and therapy. This review addresses breast cancers of unusual histological subtype with an approximate incidence <1%. Given the rarity of these tumors, the literature contains primarily case reports, small series, and population-based studies. Data are heterogeneous and almost entirely retrospective, frequently gathered over long time periods, in the context of changing pathological techniques and reporting. In addition, our understanding of the disease biology and therapeutic context has also evolved significantly over this time. There is often limited information about the specific therapies used and the rationale for choosing such an approach. Meaningful comparisons of treatment modalities are not feasible and it is not possible to define management guidelines. Instead, this review correlates the available information to give an impression of how each subgroup behaves-of the favored surgical technique, responses to therapy, and prognosis-as well as the emerging molecular data, highlighting new research areas for potential target in clinical trials. Each tumor subtype described represents a small but real cohort of patients with breast cancer, and although inferences may be made from this review, we are mindful of the paucity of data. The management of each patient must be considered in the context of their unique clinical presentation and correlated with the evidence-based principles that apply to more common breast cancer histologies. The Oncologist 2012;17:1135-1145

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“…The most consistent feature of SCCB on mammogram is the lack of microcalcifications. [10] In our patient mammography was not done. Diagnosis was confirmed on tru cut biopsy.…”

Section: Discussionmentioning

confidence: 82%

Squamous Cell Carcinoma of Breast in a 21 Years Old Female - A Rare Case Report

Kamra¹,

Munde²,

Kaur³

et al. 2016

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Squamous cell carcinoma of breast is a very aggressive, treatment-refractory tumor, with a poor prognosis. The case is being presented in view of the age of the patient for this extremely rare tumor of which histogenesis is unclear and biologic studies are urgently needed to find out relevant treatment targets. To the best of our knowledge no case of SCC of breast has been reported in 21 years of age.

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Primary squamous cell carcinoma of the breast

Cited by 82 publications

References 13 publications

Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110α Predisposes Mammary Glands to Neoplastic Transformation

Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110α Predisposes Mammary Glands to Neoplastic Transformation

Management of Unusual Histological Types of Breast Cancer

Squamous Cell Carcinoma of Breast in a 21 Years Old Female - A Rare Case Report

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