Primary Squamous Cell Carcinoma of the Ureter and Squamos Adenocarcinoma of the Renal Pelvis: 2 Case Reports

Papadopoulos, I.; Wirth, B.; Weichert-Jacobsen, K.; Loch, Tillmann; Wacker, Hans‐Heinrich

doi:10.1016/s0022-5347(01)66621-7

Cited by 13 publications

(14 citation statements)

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“…Thus, the identification of independent prognostic factors is an essential step for the evaluation of affected patients not only to predict disease evolution, thus aiding surveillance strategies, but also to identify subgroups that might benefit from adjuvant cancer therapy. Primary squamous cell carcinoma and adenocarcinoma of the renal pelvis and ureter, defined as tumors showing pure squamous or pure glandular phenotype, are highly uncommon, representing less than 1% of all primary tumors of the upper urinary tract [36]. Their pathogenesis was related to urothelial metaplasia due to long-standing chronic irritation and/or inflammation leading to dysplasia (intraepithelial neoplasia) and ultimately to squamous cell carcinoma or adenocarcinoma [28].…”

Section: Discussionmentioning

confidence: 99%

Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

et al. 2006

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The biological significance of squamous and glandular differentiation and different patterns of invasion in upper urinary tract urothelial carcinoma is unclear. We reviewed 268 cases of consecutive upper urinary tract carcinomas with respect to the presence of squamous and/or glandular differentiation and different patterns of invasion (nodular, trabecular, and infiltrative) and correlated data with patient outcome. Squamous or glandular differentiation occurred in 47/268 (18%) tumors and its presence correlated with high tumor stage (P<0.001) and grade (P<0.001). Invasive patterns were nodular in 49/227 (22%), trabecular in 95/227 (42%), and infiltrative in 83/227 (37%) tumors. The nodular pattern prevailed in low stage (P<0.001) and low-grade (P<0.001) tumors, whereas the infiltrative pattern prevailed in high stage (P<0.001) and high-grade (P<0.001) tumors. Multivariate analysis proved that tumor stage (P<0.001) and the infiltrative pattern (P<0.001) are independent predictors of metastasis-free survival, whereas tumor grade and squamous and glandular differentiation lacked independent influence on patient outcome. In conclusion, the infiltrative pattern of invasion significantly correlated with advanced disease and poor patient outcome. In contrast, the presence of squamous and/or glandular invasion did not prove independent influence on patient outcome. The pattern of invasion should be commented upon separately in the pathology report.

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Section: Discussionmentioning

confidence: 99%

Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

et al. 2006

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“…The process is assumed to be benign with urothelial metaplasia resulting from a reaction to chronic irritation, which leads to de-differentiation, dysplasia and ultimately squamous cell carcinoma or adenocarcinoma [7] . The relevant medical history often includes episodes of chronic pyelonephritis or nephrolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metastases from Squamous Cell Carcinoma of the Ureter

Ko¹,

Tsang²,

Chi³

2007

Med Princ Pract

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Objective: To present an extremely rare case of squamous cell carcinoma of the ureter with cutaneous metastases. Clinical Presentation and Intervention: A case is presented involving a 67-year-old woman presenting with a clinical history of squamous cell carcinoma of the ureter and who had undergone a nephro-ureterectomy with a bladder cuff excision in May 2004. The pathologic report showed squamous differentiation, as well as keratin pearl formation. A large regional cutaneous lesion on the chest wall was found in January 2006, and a biopsy showed metastatic malignant urothelial tumors consisting of squamous cell carcinomas. Conclusion: This report describes a case of cutaneous metastasis from a squamous cell carcinoma of the ureter that is extremely rare with a generally dismal prognosis.

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“…En consecuencia la metaplasia pavimentosa se desarrolla en un contexto de inflamación establecida, pero puede desarrollarse en forma espontánea sin que ocurra lesión urotelial identificable. Por ello, es razonable suponer que los carcinomas epidermoides podrían originarse en una superficie urotelial que ha experimentdo metaplasia pavimentosa, lo cual podría ser explicado por la acción continua del agente agresor sobre la población celular metaplásica (2,29). Este tipo de carcinoma constituye una entidad clínica poco frecuente que tiende a extenderse rápidamente, compromete estructuras perirrenales y perihiliares, incluyendo ganglios linfáticos regionales y por ello cualquier tipo de tratamiento no modifica su sobrevida, siendo casi siempre mortal en el plazo de un año y con una sobrevida quinquenal inferior al 10% (5).…”

Section: Rev Med Hered 9(1) 1998unclassified

“…El adenocarcinoma es uno de los tumores más raros del aparto urinario (6.3% en el presente estudio), con una frecuencia elevada de litiasis, presencia de hidronefrosis, cronicidad de los síntomas antes del diagnóstico y de pronóstico malo (7,29). El único caso en nuestra serie con adenocarcinomaa falleció de evidencia de enfermedad a los 45 meses después de la cirugía por secuelas de traumatismo encefalocraneano.…”

Section: Rev Med Hered 9(1) 1998unclassified

Cáncer de pelvis renal: Cuadro clínico-patológico y sobrevida.

Plasencia

Ferrer-Valle

Mantilla³

et al. 2013

Rev Med Hered

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SUMMARYstage III-IV, with a 5 year survival of 100%, and 0% respectively. The most common histologic type was the transitional cell carcinoma (75%), followed by the squamous cell carcinoma (18.7%), and adenocarcinoma (6.3%). The survival at 5 years in patients with the transitional cell carcinoma was 36%, and for all other histologic types was of 0%. Eleven patients underwent surgical treatment, 4 received surgical and radiation therapy, and one was treated with radiotherapy alone, with a 5-year survival of 19%, 75%, and 0% respectively. The 5-year survival for the entire group was of 32%. Conclusion: An early diagnosis and an adequate management using nephroureterectomy combined with incision of bladder cuff for renal pelvis tumors should be considered to obtain a longer survival. ( Rev Med Hered 1998; 9:3-9).KEY WORDS: Carcinoma, renal pelvis, clínico-pathologic picture, survival. RESUMEN Objetivo:Identificar el cuadro clínico-patológico y determinar la influencia del estadío clínico, tipo histológico y tipo de tratamiento en la sobrevida a 5 años. Material y Métodos: Revisamos las historias clínicas de 16 pacientes con carcinoma de pelvis renal tratados en el Hospital Belén, Trujillo, Perú, entre 1966 y 1995. La edad varió de 45 a 85 años, con una media de 64.7 años. Ocho pacientes fueron varones y 8 fueron mujeres. Resultados: El tiempo medio de enfermedad fue de 30 meses. Los síntomas más comunes fueron hematuria (81.3%) y dolor en en el flanco (37.5%). La mayoría de pacientes presentó palidez (43.8%) y masa palpable (32.3%) al examen clínico. El riñón izquierdo fue el más afectado (56.3%). La citología exfoliativa (PAP) detectó células neoplásicas en el 28.8% de los casos. La etapificación final fue: estadíos I-II, 31.2% y estadíos III-IV, 68.8%, con una sobrevida quinquenial de 100% y 0%, respectivamente. El tipo histológico más frecuente fue el carcinoma de células transicionales (75%), seguido por el carcinoma epidermoide (18.7%) y adenocarcinoma (6.3%). La sobrevida a 5 años para el carcinoma de células transicionales fue de 36% y para aquellos con otro tipo histológico fue de 0%. Once pacientes recibieron tratamiento quirúrgico, 4 cirugía más radioterapia y uno sólo radioterapia, con una sobrevida a 5 años de 19%, 75% y 0%, respectivamente. En la presente serie la sobrevida a 5 años fue de 32%. Conclusión: El diagnóstico precoz y el uso de la nefroureterectomía con resección en cuña en vejiga deberían ser considerados para obtener una mejor sobrevida en estos pacientes. ( Rev Med Hered 1998; 9:3-9).

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Primary Squamous Cell Carcinoma of the Ureter and Squamos Adenocarcinoma of the Renal Pelvis: 2 Case Reports

Cited by 13 publications

References 1 publication

Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

Cutaneous Metastases from Squamous Cell Carcinoma of the Ureter

Cáncer de pelvis renal: Cuadro clínico-patológico y sobrevida.

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