Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein

Abstract

We report here an autopsy case of primary squamous cell carcinoma of the liver in a 63-year-old man who had hypercalcemia and an elevated serum level of parathyroid hormone-related protein. At autopsy, primary squamous cell carcinoma of the liver was found, without distinct preceding or associated hepatic or biliary diseases; no extrahepatic primary focus of squamous cell carcinoma was found. Bone involvement was not demonstrated, either radiologically or pathologically. Immunohistochemically, parathyroid hormone-related protein was detectable in the squamous cell carcinoma cells and it may have been responsible for the hypercalcemia. Such a case has not been reported so far in the English-language or the Japanese literature.

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

“…Contrast CT showed that the solid component and irregular wall had enhancement [42][43][44][45]. MRI showed that the mass was hypointense on T1-weighted images and hyperintense on T2-weighted images [42]. Furthermore, given the current knowledge about the origin of SCC, sonographic follow-up of hepatic cysts should be needed, and surgical resection may be recommended in the case of large cysts with unclear sonographic findings [54].…”

“…It has been reported to be associated with hepatic teratoma, hepatolithiasis, or hepatic cysts with chronic inflammation and metaplasia [42,[48][49][50][51]. Because of portal vein invasion and disseminated metastases, the prognosis is very poor, with no survival longer than 1 year ever having been reported [42,52,53].…”

“…Microscopically, the tumor tissues consist of variablesized solid tumor nests with middle-to large-sized cells with intercellular bridge formation and focal keratinization [42]. Hepatectomy, systemic chemotherapy (5-fluorouracil and cisplatin), or TACE could be considered for the treatment [55,56].…”

“…Calcifications were seen in the solid components. Contrast CT showed that the solid component and irregular wall had enhancement [42][43][44][45]. MRI showed that the mass was hypointense on T1-weighted images and hyperintense on T2-weighted images [42].…”

“…Calcifications could be seen in the solid components. Contrast CT showed that the solid component had slight enhancement [42][43][44][45]. MRI imaging can provide more useful information than CT, and shows the characteristic features of hyperintense on T1WI and hypointense on T2WI [39].…”