Primary squamous cell carcinoma of the frontal sinus

Abstract

We report a 74-year-old Japanese man with squamous cell carcinoma (SCC) originating in the frontal sinus. It presented as a cutaneous nodule on his right forehead. Magnetic resonance imaging (MRI) revealed invasion of the anterior wall of the ethmoid sinus, the frontal bone, and possibly the meninx by a frontal sinus carcinoma. Despite right fronto craniotomy with en bloc resection followed by two courses of radiation therapy and chemotherapy with 5-fluorouracil and nedaplatin or TS-1 he died of disease-related causes 20 months later. Herein, we present a detailed description of this patient and a review of the published work.

Primary carcinoma of the frontal sinus with extensive intracranial invasion: A case report and review of the literature

“…In 1907, Prawssud (6) was the first to report cell carcinoma of the frontal sinus, and in 1999 Huang (7) was the first to report a case of primary carcinoma of the frontal sinus in China. Paranasal sinus carcinomas present most commonly with nasal obstruction, nasal bleeding, nasal discharge, anosmia, proptosis, diplopia, facial pain, headache and oppressive sensation (8). These symptoms of frontal sinus cancers have been mimicked with other lesions, including mucoceles, pyoceles or osteomyelitis.…”

“…In 1969, Frew (15) reported 6 cases of frontal sinus cancer, and the average survival duration was only 14 months. Yoshida et al (8) reported the case of a 74-year-old male with frontal sinus cancer. Although this patient underwent total resection followed by radiotherapy (50 Gy), the tumor recurred three months after surgery and the patient succumbed 20 months after surgery due to a tumor-associated reason.…”

Primary Squamous Cell Carcinoma of the Frontal Sinus Treated With En Bloc Resection -Case Report-

“…Approximately 3% of all head and neck cancers originate in the nasal or paranasal sinuses; the annual incidence is 1-3 cases per 100 000 population. Primary frontal sinus carcinoma accounts for 0.3-1.0% of the nasal or paranasal sinus cancers, 2,11) so the standard therapy has not been well established. Generally, nasal and paranasal carcinomas are treated with multimodal combined therapy such as surgery and radiotherapy with or without chemotherapy.…”

“…2,11) Surgical cure of this lesion is very difficult because of the anatomical complexity of the frontal sinus, and the prognosis is poor, despite use of radiation and/or chemotherapy. 1,2,[4][5][6][7]10,11) En bloc resection with a clear margin is undoubtedly essential to achieve tumor control. 4,9) Here we present a case of primary frontal sinus squamous cell carcinoma (SCC) which was successfully treated by surgical resection.…”

Superior orbitectomy and chemotherapy in a dog with frontal sinus squamous cell carcinoma: a case report and review of the literature

“…It was first described in humans in 1907 by Prawssud . Only 0.009–0.03% of all head and neck cancers in men are primary frontal sinus‐SCC (pFS‐SCC) . Mine et al.…”