Primary squamous cell carcinoma of the common bile duct

Zhong, Lin; Qi, Wenjing; Tao, Fengming; Zhang, Lizhi; Kong, Jienan

doi:10.4103/ijpm.ijpm_633_20

Cited by 1 publication

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“…Laboratory examinations indicated impaired liver function with elevated CA19-9 levels. However, only five of the 14 patients listed in Table 1 had elevated CA19-9 levels, suggesting that the specificity of CA 19-9 is lower for SCC than for cholangioadenocarcinoma[ 19 ]. However, the relevant data are limited.…”

Section: Discussionmentioning

confidence: 99%

Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature

Ma,

Wang,

Yang

et al. 2024

World J Clin Oncol

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BACKGROUND Cholangiocarcinoma is the most common malignancy of the biliary tree and has a poor prognosis. Adenocarcinoma is the most common pathological type of cholangiocarcinomas, but rare squamous, adenosquamous, and mucinous variants have been reported without adequate clinical data. CASE SUMMARY This report describes a rare case of primary squamous cell carcinoma (SCC) of the intrahepatic bile duct. The patient was admitted with a tumor in the hepatic caudate lobe with no obvious clinical symptoms. Examination revealed hepatitis B surface antigen positivity, a slight increase in alfa-fetoprotein to 16.34 ng/mL, and an irregular slightly heterogeneous enhancing lesion in the hepatic caudate lobe, which was initially thought to be hepatocellular carcinoma. Laparoscopic resection was performed, and the final pathology suggested a rare primary SCC of the intrahepatic bile duct. Immunohistochemistry indicated positivity for villin, partial positivity for p63, and negativity for hepatocyte, CK7, CK8, CK19, and CK20. The Ki-67 index was approximately 60%. The patient received six cycles of Tegio chemotherapy. A new lesion was detected in the liver after 15 months. The surgery was performed, and the patient was followed-up at a local hospital. To date, no new lesions have been observed. CONCLUSION Surgery is the first choice for resectable lesions, and combined chemotherapy based on pathology is essential for increasing overall survival.

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Section: Discussionmentioning

confidence: 99%