1991
DOI: 10.1038/350398a0
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Primary structure and functional expression from complementary DNA of a brain calcium channel

Abstract: The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha 2 and beta subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinj… Show more

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Cited by 826 publications
(539 citation statements)
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“…Mature X. laevis female frogs were from Nasco (Wisconsin, USA). The ~A subunit (pSPCBI-2) was from Mori et al [6] and thefll ~ clone from Pragnell et al [25].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Mature X. laevis female frogs were from Nasco (Wisconsin, USA). The ~A subunit (pSPCBI-2) was from Mori et al [6] and thefll ~ clone from Pragnell et al [25].…”
Section: Methodsmentioning
confidence: 99%
“…Both domains determine the attachment of the fl subunit to the c~ 1 channel. This linkage is required for the observed 13 subunit regulation of the current properties of the C~l subunit, that is the increase in current amplitude [6][7][8][9][10] and the modifications in kinetics and voltage dependence of the channel [11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%
“…Calcium channels transiently expressed from cRNA of CaCh4 induce high-voltage-activated calcium currents that are insensitive to nifedipine and o-conotoxin but are inhibited by a mixture of toxins from the funnel web spider that characterize this channel as a P-type calcium channel (Mori et al 1991).…”
Section: The a Subunitmentioning
confidence: 99%
“…The gene codes for the α 1A pore‐forming subunit of Ca 2+ voltage‐gated Cav2.1 channels and is widely expressed throughout the central nervous system (CNS) (Mori et al. 1991; Westenbroek et al. 1995).…”
Section: Introductionmentioning
confidence: 99%