Primary Subcutaneous Synovial Sarcoma: First Reported Subcutaneous Case Showing TLE1 Immunoreactivity

Alegría-Landa, Victoria; Nájera, Laura; Massa, Dolores Suarez; Roustán, Gastón; Río, M. del; Kutzner, Heinz; Requena, Luis

doi:10.1097/dad.0000000000001172

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…Identifying a second, biphasic pattern, such as the formation of neoplastic glands, can be a helpful morphological feature to raise the possibility of superficial synovial sarcoma. Inclusive of this study, only 14 cases of cutaneous synovial sarcoma have been reported 28–32 . These tend to present as small, superficial biphasic tumors (9/15; 60%) centered within the dermis or subcutis.…”

Section: Discussionmentioning

confidence: 77%

“…Inclusive of this study, only 14 cases of cutaneous synovial sarcoma have been reported. [28][29][30][31][32] These tend to present as small, superficial biphasic tumors (9/15; 60%) centered within the dermis or subcutis. One helpful feature is the expression of keratin and EMA without co-expression of p40 or p63 in the spindle cell component, which helps to differentiate these from spindle cell/ sarcomatoid carcinoma of the skin.…”

Section: Immunohistochemical Findingsmentioning

confidence: 99%

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Fusion‐driven cutaneous and superficial mesenchymal and adnexal tumors—A clinicopathologic and molecular study of 15 cases, including a novel case of ACTB::ZMIZ2‐rearranged adnexal carcinoma

Dehner,

Johnson,

Wieland

et al. 2024

J Cutan Pathol

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BackgroundWhile the list of fusion‐driven soft tissue neoplasms is expanding rapidly, their importance among cutaneous and superficial mesenchymal and adnexal neoplasms remains poorly understood. This challenge is especially evident in cases with ambiguous histopathology that are difficult to classify based on morphology.AimsOur goal was to investigate the benefits of next‐generation sequencing in diagnosing complex cutaneous neoplasms.Materials & MethodsDepartmental archives were searched for fusion‐driven cutaneous neoplasms. Slides were retrieved and clinical information including follow‐up was obtained.ResultsFifteen cases occurred in eight female and seven male patients, with a median age of 26 years (range: 1–83) at diagnosis. Tumors involved the extremities (9), scalp (5), and head and neck (1). Predominant features included myoepithelial (5), nested spindled with clear cytoplasm (2), atypical adnexal/squamoid (2), small round blue cell (2), cellular spindled (3), and fibrohistiocytic morphology (1). Most frequently encountered fusions involved EWSR1 (6) fused to ERG (1), FLI1 (1), CREB1 (2), CREM (1), PBX3 (1), followed by PLAG1 (4) with LIFR (2), TRPS1 (1) and CHCHD7. Additional fusions encountered were YAP1::NUTM1, EML4::ALK, SS18::SSX1 (2), and a novel fusion: ACTB::ZMIZ2. Integration of histologic features and molecular findings led to final diagnoses of primary cutaneous Ewing sarcoma (2), soft tissue myoepithelioma (4), cutaneous syncytial myoepithelioma (1), cutaneous adnexal carcinoma (1), porocarcinoma (1), inflammatory myofibroblastic tumor (1), synovial sarcoma (2), clear cell sarcoma (2), and angiomatoid fibrous histiocytoma (1).Discussion and conclusionOur results show that fusion testing can be a helpful diagnostic tool, especially in cases with unusual or uncommon morphology in superficial sites. Furthermore, it can allow for the identification of potential therapeutic targets in some instances.

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Section: Discussionmentioning

confidence: 77%

Section: Immunohistochemical Findingsmentioning

confidence: 99%

Fusion‐driven cutaneous and superficial mesenchymal and adnexal tumors—A clinicopathologic and molecular study of 15 cases, including a novel case of ACTB::ZMIZ2‐rearranged adnexal carcinoma

Dehner,

Johnson,

Wieland

et al. 2024

J Cutan Pathol

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Primary Subcutaneous Spindle Cell Synovial Sarcoma: First Reported Case

Sotiriou

Kotoula

Raptou

et al. 2020

The American Journal of Dermatopathology

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Primary cutaneous solitary fibrous tumor with entrapped eccrine components

Tran

2020

J Cutan Pathol

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First described in the pleura, solitary fibrous tumor (SFT) was subsequently reported in a variety of organ systems. Compared to other anatomic sites, primary cutaneous and superficial SFTs are relatively rare. Although several histopathologic variants of cutaneous and superficial SFT have been described, a primary cutaneous SFT harboring glandular components has not hitherto been documented in the literature. The current case report describes a spindle cell neoplasm of the right finger in a female patient with characteristic morphologic and immunohistochemical features of a SFT. Unexpectedly, various glandular and ductal components were identified in the SFT. A few hyperplastic lobules of sweat glands demonstrating similar morphology as the intratumoral glandular components and composed of secretory coils displaying mucinous metaplasia and ducts were detected in the attached subcutaneous tissue, suggestive of an inductive or obstructive effect of the SFT on the eccrine units. The intratumoral glands and ducts were judged to represent entrapped benign eccrine components from the attached subcutaneous tissue. Since this variant of SFT with entrapped eccrine components could mimic many biphasic epithelial and stromal tumors, pathologists should be aware of this unusual variant of SFT to avoid potential erroneous diagnosis, particularly mistaken confusion with a biphasic synovial sarcoma.

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Primary Subcutaneous Synovial Sarcoma: First Reported Subcutaneous Case Showing TLE1 Immunoreactivity

Cited by 5 publications

References 12 publications

Fusion‐driven cutaneous and superficial mesenchymal and adnexal tumors—A clinicopathologic and molecular study of 15 cases, including a novel case of ACTB::ZMIZ2‐rearranged adnexal carcinoma

Fusion‐driven cutaneous and superficial mesenchymal and adnexal tumors—A clinicopathologic and molecular study of 15 cases, including a novel case of ACTB::ZMIZ2‐rearranged adnexal carcinoma

Primary Subcutaneous Spindle Cell Synovial Sarcoma: First Reported Case

Primary cutaneous solitary fibrous tumor with entrapped eccrine components

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