Primary Subglottic Cancer

Dahm, J. David; Sessions, Donald G.; Paniello, Randal C.; Harvey, Joseph E.

doi:10.1097/00005537-199805000-00022

Cited by 61 publications

(51 citation statements)

References 25 publications

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“…The symptoms with subglottic or tracheal tumor include prolonged cough and wheezing. It can be misdiagnosed as asthma (Garas and McGuirt, 2006;Dahm et al, 1998;Kokturk et al, 2005;Goyal et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Subglottic adenoid cystic carcinoma mistaken for asthma

Wang

2009

J. Zhejiang Univ. Sci. B

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Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress and cough worsening after physical exertion, and was diagnosed with, and treated as, bronchial asthma. Regular anti-asthmatic therapy did not improve the symptoms. Until a sudden dyspnea, a cervicothoracic computerized tomography (CT) revealed that her upper airway was obstructed by a laryngeal tumor. The patient was diagnosed with a subglottic adenoid cystic carcinoma and treated with complete surgical excision and adjuvant radiation therapy. Follow-up endoscopy and laryngeal magnetic resonance imaging (MRI) at six months showed no recurrence of the tumor. The diagnosis of subglottic adenoid cystic carcinoma should be considered in patients who are characterized by dyspnea, cough, and stridor, but do not respond to regular anti-asthmatic therapy.

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Section: Discussionmentioning

confidence: 99%

Subglottic adenoid cystic carcinoma mistaken for asthma

Wang

2009

J. Zhejiang Univ. Sci. B

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“…This is a generic term used for any type of neck dissection, such as conventional radical neck dissection, modified radical neck dissection, selective neck dissection (3 node levels resected), or limited neck dissection (no more than 2 node levels resected) [14]. Elective (prophylactic) neck dissection has been recommended for the N0 neck in patients with T2-T4 supraglottic cancers [15][16][17], T3-T4 glottic cancers [17][18][19][20][21][22], T3-T4 subglottic cancers [17,[22][23][24] and in patients with recurrent supraglottic and advanced glottic cancers treated by radiotherapy and salvaged by laryngectomy [25].…”

Section: Elective Neck Dissectionmentioning

confidence: 99%

“…The incidence of supraclavicular (level V), middle (level III) and lower jugular (level IV) node metastases, which are only present after the involvement of the paratracheal nodes, is low [24]. Glottic, supraglottic, transglottic and subglottic cancers may metastasize to precricoid or prelaryngeal lymph node or Delphian node and to sub-Delphian nodes in the anterior tracheal compartment of level VI [23,[49][50][51][52][53][54][55]. Rarely, laryngeal cancer has metastasized to the axillary lymph nodes [56][57][58], and the axilla can become the major lymphatic drainage site from the anterior and lateral neck [58].…”

Section: Choice Of Surgical Procedures For Elective Treatment Of the Neckmentioning

confidence: 99%

Surgical Treatment of the Neck in Cancer of the Larynx

Ferlito¹,

Silver²,

Rinaldo³

et al. 2000

ORL

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Current concepts in management of the clinically negative and clinically positive neck in laryngeal cancer are reviewed. Occult disease in the neck not detected by physical and radiographic examination may also be difficult to identify on routine histologic examination. Immunohistochemistry or molecular analysis may detect metastatic involvement not apparent by light microscopy. The surgeon should be aware of the relatively high incidence of micrometastases in patients with laryngeal cancer to establish optimal treatment approaches. Elective treatment of the neck is recommended for supraglottic tumors staged T2 or higher, and glottic or subglottic tumors staged T3 or higher.The neck may be treated electively by either surgery or irradiation, but irradiation is best reserved for cases where that modality is employed for the primary tumor. Elective neck dissection provides important information for prognostic purposes and therapeutic decisions, by establishing the presence, number, location and nature of occult lymph node metastases. The selective lateral neck dissection (levels II, III and IV), unilateral or bilateral, is the procedure of choice for elective treatment. Paratracheal nodes (level VI) should be dissected in cases of advanced glottic and subglottic cancer. Complete radical or functional neck dissections are excessive in extent, as levels I and V are almost never involved. Sentinel lymph node biopsy may fail to detect tumor on frozen section examination or may not reveal ‘skip’ metastases.The clinically involved neck is usually treated by complete radical or functional neck dissection of levels I through V. Selective neck dissection has been employed successfully in selected cases, particularly for N1 or occasionally N2 nodal involvement. The selective neck dissection can be extended to include structures at risk. More advanced disease has been treated in this manner often in association with adjuvant chemotherapy and/or irradiation. While the benefit of adjuvant treatment is difficult to assess, it appears most useful in cases with extranodal spread of disease, a factor associated with the worst prognosis.

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“…Radiotherapy alone has shown a low 5-year survival rate that varies from 22.2% [5] to 36% [23] and up to 61% [24]. Surgery alone has shown a better 5-year survival rate: 42% for some authors [5,23] and as high as 70% for others [19].…”

Section: Introductionmentioning

confidence: 99%

Primary carcinoma of the subglottic larynx

Santoro

Turelli

Polli

2000

European Archives of Oto-Rhino-Laryngology

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Primary cancer of the subglottic region is very rare and delay in diagnosis often leads to a poor prognosis. We retrospectively reviewed 49 patients with primary cancer of the subglottic larynx observed from 1969 to 1993 in the ORL Clinic of the University of Florence. This number constitutes 1.6% of all laryngeal cancers observed during this period. Four (8.2%) patients were stage T1, 13 (26.5%) T2, 27 (55.1%) T3, and 5 (10.2%) T4. Forty-one patients were eligible for assessing the disease-free five-year survival rate, 17 of whom were treated with surgery alone, 6 with radiotherapy alone and 18 with combination therapy (surgery for the primary tumor and postoperative radiotherapy for cervical nodes). The five-year survival rate for the three treatment types was 47%, 0% and 83.3%, respectively. The overall survival rate was 56.1%. Combination therapy produced a significantly higher (P = 0.001) disease-free survival than surgery alone or radiotherapy alone.

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Primary Subglottic Cancer

Cited by 61 publications

References 25 publications

Subglottic adenoid cystic carcinoma mistaken for asthma

Subglottic adenoid cystic carcinoma mistaken for asthma

Surgical Treatment of the Neck in Cancer of the Larynx

Primary carcinoma of the subglottic larynx

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