Primary superficial femoral vein leiomyosarcoma: Report of a case

Yfadopoulos, Dimitrios K; Nikolopoulos, Dimitrios; Novi, Evanthia; Psaroudakis, A.

doi:10.1007/s00595-010-4507-6

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…Only 5% of all reported leiomyosarcoma cases were of vascular origin ( 6 ). Among the reported cases of vascular leiomyosarcoma, 40 were located in the iliac vein ( 7 ), while 8 were located in the superficial femoral vein ( 8 ). Among these 48 cases, there were no cases of PE due to leiomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Embolism Caused by Intravenous Leiomyosarcoma of the Lower Limb

et al. 2018

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Pulmonary embolism (PE) is usually caused by thrombosis or tumor. We report the long-term survival of a patient with PE due to a leiomyosarcoma in the deep vein. A 71-year-old woman complained of dyspnea and swelling of the left lower limb. Computed tomography revealed filling defects in the pulmonary arteries and deep vein. She was diagnosed with PE caused by venous thrombosis and treated with anticoagulant therapy. Her symptoms were prolonged, and D-dimer tests remained negative. Biopsy of the substance in the deep vein revealed leiomyosarcoma. The possibility of PE caused by extravascular or intravascular tumors should be considered when a patient is negative for D-dimer.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Embolism Caused by Intravenous Leiomyosarcoma of the Lower Limb

et al. 2018

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“…MRI and CT allow visualization of the tumor, determination of the venous origin, and relationship with surrounding structures. Current treatment of choice exists of limb-preserving surgery and adjuvant radiotherapy and/ or chemotherapy (1).…”

Section: Commentmentioning

confidence: 99%

Leiomyosarcoma of the great saphenous vein

Werbrouck

Marrannes

Gellens

et al. 2013

Journal of the Belgian Society of Radiology

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A 57-year-old man presented to his general practitioner with a palpable, painless mass in the right groin. There was no swelling of the ipsilateral leg. He was referred for diagnostic imaging. Ultrasound (US) identified a moderate circumscribed, heterogeneous hypoechogenic mass in the right groin, probably in or next to the distal great saphenous vein, measuring approximately 18 × 25 × 26 mm. Power Doppler revealed a centrally strong vascular signal, with both arterial and venous signals (Fig. A). The origin of the mass was not entirely clear on US and subsequently an MRI and an US-guided puncture were performed. A homogeneous hypo-intense mass on T1 weighted imaging (WI) and slightly heterogeneous hyperintense lesion on T2 WI (Fig. B) was revealed, arising from the great saphenous vein, extending into the subcutaneous fat. The great saphenous vein was at least partially thrombosed, with a thickened wall and a mild surrounding infiltration. There were no susceptibility artefacts on gradient echo. Intravenous injection of gadolinium resulted in a strong enhancement in of the lesion (Fig. C, D). Small superficial veins ran into the lesion. The soft tissues surrounding the mass were edematous. There were multiple, slightly enlarged inguinal lymph most parts nodes. No evidence for invasion of the adjacent inguinal canal or muscular structures was found. These finding were suggestive of a primary, possibly malign, tumor. Puncure of the lesion showed a spindle cell mesenchymal proliferation. Total resection of the lesion was performed (Fig. E, F), and anatomopathological examination showed a moderately differentiated intravascular leiomyosarcoma with limited pleiomorphic dedifferentiation (5-10%). A subsequent CT of the thorax and the abdomen was negative for tumoral spread. CommentLeiomyosarcomas are aggressive soft tissue sarcomas arising from smooth muscle cells, and can be divided in three types according to their site of origin: soft tissue (most common), cutaneous (best prognosis) and vascular (arising from the muscular wall). Although five times more common than arterial leiomyosarcomas, primary venous leiomyosarcomas constitute for less than one in every 100,000 malignant tumours, and only 10% of these originate from the great saphenous vein. The inferior caval vein is the predominant venous location, accounting for almost half of the cases, followed by the pulmonary, renal, common femoral, saphenous, superior mesenteric, and ovarian veins, and superior caval vein. The development can be divided into three stages; nonocclusive stage (asymptomatic or nonspecific symptoms), occlusive stage (ranging from asymptomatic to phlebitis or deep vein thrombosis), and terminal stage (distant metastases, especially in the lungs and liver). Color Doppler US is highly reliable in the early, nonocclusive stage. MRI and CT allow visualization of the tumor, determination of the venous origin, and relationship with surrounding structures. Current treatment of choice exists of limb-preserving surgery and adjuvant radiotherapy and...

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“…This malignant lesion arises from the smooth muscle cells mostly found in the uterus and the gastrointestinal tract 2. Primary venous leiomyosarcomas are even rarer, representing less than 2% of all leiomyosarcomas, and majority of them occur in large veins, specifically the inferior vena cava 3.…”

Section: Introductionmentioning

confidence: 99%

Leiomyosarcoma presenting as ‘idiopathic’ unilateral lower limb lymphoedema

Kadir¹,

Naik

Chandrasekar

2017

BMJ Case Reports

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A 74-year-old woman presented with an 8-year history of unilateral swelling of her right lower limb, which was thought to be 'idiopathic' lymphoedema until she noticed a painless swelling in her right groin. Physical examination showed a painless, non-pulsatile, deep-seated mass in her right proximal thigh with significant lymphoedema distally. MRI scan showed a large mass at her right inguinal region, involving the common femoral vein. Histological examination on complete excision revealed leiomyosarcoma. It is important to exclude proximal obstructive lesion before making a diagnosis of unilateral idiopathic lower limb lymphoedema.

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Primary superficial femoral vein leiomyosarcoma: Report of a case

Cited by 6 publications

References 19 publications

Pulmonary Embolism Caused by Intravenous Leiomyosarcoma of the Lower Limb

Pulmonary Embolism Caused by Intravenous Leiomyosarcoma of the Lower Limb

Leiomyosarcoma of the great saphenous vein

Leiomyosarcoma presenting as ‘idiopathic’ unilateral lower limb lymphoedema

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