Primary Synovial Sarcoma of the Lung

Zamarrón, Carlos; Abdulkader, Ihab; Alvarez, Uxio Calvo; Barón, Franciisco Javiver; Prim, Jose Maria Garcia; Ledo, Ramiro; Forteza, Jerónimo

doi:10.2169/internalmedicine.45.1508

Cited by 19 publications

(20 citation statements)

References 18 publications

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“…Other presentations include haemoptysis and cough and a growing mass. Mostly patients present with non-specific symptoms [2,11]. Our patient presented with cough and dyspnoea.…”

Section: Discussionmentioning

confidence: 72%

“…S ynovial sarcoma accounts for 5-14% of all soft tissue tumours [1,2]. Approximately 800 new cases occur in United States every year [1].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 800 new cases occur in United States every year [1]. Primary pulmonary sarcomas are extremely rare accounting for 0.1-0.5% of all lung malignancies [2,3]. This rare incidence makes the immediate diagnosis a challenge.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synovial sarcoma of the lung presenting late with compression of mediastinal structures and its successful resection: A case report

Fatimi

Anees

Hanif

et al. 2011

Heart, Lung and Circulation

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“…Other presentations include haemoptysis and cough and a growing mass. Mostly patients present with non-specific symptoms [2,11]. Our patient presented with cough and dyspnoea.…”

Section: Discussionmentioning

confidence: 72%

“…S ynovial sarcoma accounts for 5-14% of all soft tissue tumours [1,2]. Approximately 800 new cases occur in United States every year [1].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synovial sarcoma of the lung presenting late with compression of mediastinal structures and its successful resection: A case report

Fatimi

Anees

Hanif

et al. 2011

Heart, Lung and Circulation

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“…Review of literature shows only few case reports and small case series that report tumours of similar lineage [1,[11][12][13]. The English literature documents barely 60 cases of synovial sarcoma at pleuropulmonary region till 2005 [14].…”

Section: Discussionmentioning

confidence: 99%

Primary Pleuropulmonary Synovial Sarcoma with Brain Metastases in a Paediatric Patient: An Unusual Presentation

Chirmade

Parikh

Anand

et al. 2017

Advances in Respiratory Medicine

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Primary lung neoplasms are rare in children. The most common primary lung malignancies in children are pleuropulmonary blastoma and carcinoid tumour. Synovial sarcoma (SS) accounts for approximately 1% of all childhood malignancies. In absolute terms, the SS of the lungs and pleura are extremely rare and pose a diagnostic difficulty. Soft tissue sarcomas usually have a high potential for metastases, however, metastasis to the brain is rare, even in widely disseminated disease, and it has been described only in 3 case reports previously. Primary pleuropulmonary SS with brain metastases is even rarer. Here we present a case of an 11-year-old boy who presented with respiratory complaints, viz. fever and cough for 20 days. Initial impression was lung abscess, however, on histopathological, immunohistochemical and molecular study, the disorder was diagnosed as synovial sarcoma. After a week from the first consult, the child developed neurological symptoms, viz., an episode of convulsion and gradually worsening power of the lower limb. Computed tomography scan and Magnetic Resonance Spectroscopy was suggestive of brain metastases. Given the rarity of primary lung neoplasms in children, clinical detection remains a challenge. Delayed diagnoses are common as respiratory symptoms may be attributed to inflammatory or infective processes. Primary pleuropulmonary synovial sarcoma is a rare tumour and it is not known to commonly metastasise to the brain. Though rare, primary pleuropulmonary SS should be considered an important differential among peadiatric primary lung neoplasms due to its potential for curability if detected early, and more aggressive metastatic pattern, e.g. brain metastases making early detection imperative.

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“…[14] Immunohistochemical expression of the Mic2 gene product (CD99) in ES/PNET is helpful in separating this entity from other small round-cell tumours. [15] However, CD99 expression is not specific for ES/PNET, as it can be expressed by other sarcomas, including poorly differentiated synovial sarcoma[16] and mesenchymal chondrosarcoma. Other ancillary techniques, including cytogenetic analysis, reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization may provide further aid in confirming the diagnosis of ES/PNET.…”

Section: Discussionmentioning

confidence: 99%

A rare mediastinal tumour in a young male mimicking massive pleural effusion

et al. 2012

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A 30-year-old male, carpenter by profession, presented with a history of dry cough and progressive shortness of breath for two months along with right-sided chest pain for one and a half months. The clinico-radiological picture was suggestive of right-sided massive pleural effusion. Computed tomography (CT) scan of the thorax showed a huge mediastinal mass occupying the entire right hemithorax with very small amount of pleural effusion. CT-guided fine needle aspiration cytology and tru-cut biopsy from the mass both revealed small round-cell tumour, possibly small cell carcinoma of the lung. However, on immunohistochemistry tumour cells expressed Mic-2 and it was consistent with a diagnosis of primitive neuroectodermal tumour.

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Primary Synovial Sarcoma of the Lung

Abstract: A 45 -year-old

Cited by 19 publications

References 18 publications

Synovial sarcoma of the lung presenting late with compression of mediastinal structures and its successful resection: A case report

Synovial sarcoma of the lung presenting late with compression of mediastinal structures and its successful resection: A case report

Primary Pleuropulmonary Synovial Sarcoma with Brain Metastases in a Paediatric Patient: An Unusual Presentation

A rare mediastinal tumour in a young male mimicking massive pleural effusion

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