Primary synovial sarcoma of the prostate

Abstract

up to 80 h post mortem for quantitative analyses of immunologically relevant cellular molecules. acknowledgementsThe authors express their gratitude to Karin Westermann for assisting with the immunohistochemistry and Sheila Fryk for correction of the English. This study was supported by the 'Deutsche Forschungsgemeinschaft', project grant SFB587-B5.

Synovial sarcoma of nerve

“…Synovial sarcomas most often involve the extremities of adolescents and young adults but may occur in patients of any age and in any soft tissue or even visceral location. Indeed, with the discovery that synovial sarcomas carry a variety of specific translocations, including t(X;18)(p11.23;q11)(SS18-SSX1) (∼65% of cases), t(X;18)(p11.21;q11) (SS18-SSX2) (∼35% of cases), t(X;18)(p11;q11) (SS18-SSX4) (b1% of cases), and t(X;20)(p11;q13.3) (SS181-SSX1) (b1% of cases), the diagnostic application of molecular techniques (RT-PCR, FISH) has made it increasingly apparent that many synovial sarcomas occur in unusual locations [18,19]. Primary synovial sarcomas of nerve are very rare, there being only 22 reported cases, inclusive of those in the present series (Tables 1 and 2) [5][6][7][8][9][10][11][12]14,15].…”

Spindle cell lesions of the adult prostate

“…Other sarcomas involving the prostate that have been described as case reports include synovial sarcoma, [38][39][40] osteogenic sarcoma, 41 malignant fibrous histiocytoma, [42][43][44] angiosarcoma, 45 and malignant peripheral nerve sheath tumors. 47 A single case of granular cell tumor of the prostate has also been recorded.…”

Primary Intraprostatic Synovial Sarcoma

“…Only 2 of the 10 documented cases of intraprostatic synovial sarcoma have reported the tumor's specific SYT-SSX fusion gene, one exhibiting the SYT-SSX1 fusion and the other the SYT-SSX2 fusion. 10,11 The correlation between fusion transcript and histologic pattern discussed above was not observed, as both tumors were of the monophasic fibrous type. Beyond the t(X;18) translocation, synovial sarcomas demonstrate a diverse array of genetic mutations.…”

“…Tumors ranged in size from 4 to 15 cm, with a mean size of 9.9 cm in greatest dimension. [7][8][9][10][11][12][13] HISTOPATHOLOGY Not surprisingly, intraprostatic synovial sarcoma histologically mirrors those found elsewhere in the body. However, to the best of our knowledge only the biphasic and monophasic fibrous types have been described in the English literature to date.…”

“…[7][8][9][10][11][12][13] Of these, the mean age at time of diagnosis is 42 years old, with an overall age range of 28 to 63 years. It typically presents with nonspecific lower urinary tract symptoms, including dysuria, increased urinary frequency, and nocturia.…”