Primary T-cell lymphoblastic lymphoma of the cavernous sinus

Sadruddin, Sarfaraz; Medeiros, L. Jeffrey; DeMonte, Franco

doi:10.3171/2009.7.peds09232

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…Lymphoma has been described in the cavernous sinus but typically does not respond or have a sustained response to steroids; nevertheless, because our case lacks long-term follow-up, it is not possible to definitively rule out the possibility of lymphoma. 8 Given the rapid improvement, this presentation was more consistent with THS. This patient was seen 1 month after discharge with resolution of symptoms but unfortunately was lost to follow-up afterward.…”

Section: Discussionmentioning

confidence: 65%

A Case of Tolosa-Hunt Syndrome With Discoid Lupus Erythematosus

Finkelsztein

Cheng

2019

The Neurohospitalist

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The occurrence of Tolosa-Hunt syndrome (THS) in the setting of discoid lupus erythematosus (DLE) has not been previously reported. We report a case of a 55-year-old Chinese man with established cutaneous lupus who presented with 1 week of worsening blurry vision and ptosis of the left eye with severe headache 2 weeks prior to presentation. His cranial nerve examination was significant for left afferent pupillary defect, red desaturation, ptosis, and oculomotor nerve palsy. He also presented with active DLE lesions. Magnetic resonance imaging brain demonstrated asymmetric thickening and enhancement of the left cavernous sinus consistent with THS. After a 4-week gradual steroid taper his ophthalmoplegia resolved. The unusual occurrence of THS and DLE prompts consideration of nonsystemic autoimmune disorders in diagnosis of THS.

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Section: Discussionmentioning

confidence: 65%

A Case of Tolosa-Hunt Syndrome With Discoid Lupus Erythematosus

Finkelsztein

Cheng

2019

The Neurohospitalist

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“…Among tumor processes which can affect the trigeminal nerve and trigger TN, neurinoma and meningioma are the most common, although many other entities, included lymphoma, have been already described. [ 3 9 12 17 22 25 30 34 36 37 40 ] More rarely, granulomatous diseases, such as Wegener; s granulomatosis,[ 1 7 24 ] tuberculosis,[ 16 ] and sarcoidosis[ 2 5 6 33 ] involving the Meckel's cave have been described as the etiology of TN. However, to our knowledge, there are no previous reports in the literature of LYG affecting the Meckel's cave or describing this entity as an etiological trigger of TN.…”

Section: Discussionmentioning

confidence: 99%

Unique case of trigeminal neuralgia due to Epstein-Barr-virus-associated B-cell lymphomatoid granulomatosis of the Meckel's cave and cavernous sinus: Important clinical and therapeutic implications

Sponton¹,

Ayyad²,

Archavlis³

et al. 2018

Surg Neurol Int

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Background:Trigeminal neuralgia (TN) represents one of the most disabling pain syndromes. Several diseases have been described as etiological triggers of TN, vascular compression of the trigeminal nerve being the most frequent cause. Here, we describe for the first time a rare case of TN caused by an infiltration of an isolated Epstein–Barr virus (EBV) B-cell lymphomatoid granulomatosis (LYG) mass into the Meckel's cave and cavernous sinus.Case Description:A 51-year-old woman undergoing immunosuppressant treatment for Crohn's disease presented due to right-sided TN. Magnetic resonance imaging (MRI) scans revealed an isolated lesion affecting the right Meckel's cave and lateral wall of the cavernous sinus. We accomplished tumor resection through a subtemporal extradural approach and the patient recovered successfully from surgery. Histological examination revealed an LYG, and a blood test confirmed low but positive EBV counts. The immunosuppressant therapy was discontinued and we assumed a watchful waiting management. During a 41-months’ follow-up there was neither evidence of LYG recurrence nor an increase of EBV counts.Conclusions:LYG, an angiodestructive disease associated with EBV reactivation in the context of immune dysfunction and often associated with an aggressive behavior or even malignant transformation, should be considered as a rare differential diagnosis of TN associated with skull base lesions. The management of this rare disease is still controversial and varies from limiting the treatment to correcting immune dysfunction up to chemotherapy. In this case of an isolated mass, surgical excision and discontinuation of immunosuppressants were effective to prevent the relapse of the disease in a long-term follow-up.

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“… 16 Primary cavernous sinus lymphoma is a rare entity with 8 cases described in the literature - however, these lesions are amenable to systemic chemotherapy and the prognosis of cavernous sinus lymphoma with treatment is far better than that of metastasis from colorectal carcinoma with an average survival greater than 18 months. 17 , 18 , 19 , 20 , 21 , 22 Meningioma is the most common CNS tumor (40%) 23 and should be ruled out in any cavernous sinus mass. When arising in the cavernous sinus, meningioma can be managed with a combinations of observation, microsurgical resection and stereotactic radiosurgery (SRS), and generally carries an excellent prognosis with 90% demonstrating tumor control after 5 years.…”

Section: Discussionmentioning

confidence: 99%

Cavernous sinus syndrome associated with metastatic colorectal cancer and perineural spread along the trigeminal nerve

Nassrallah

Sun

Guiot

et al. 2017

American Journal of Ophthalmology Case Reports

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PurposeWe report the case of a patient with cavernous sinus syndrome associated with biopsy-confirmed metastasis from colorectal cancer.ObservationsA patient known for laryngeal carcinoma and metastatic colorectal carcinoma presented with symptoms of left trigeminal neuralgia and progressive, near-complete ophthalmoplegia. Magnetic resonance imaging (MRI) revealed a mass in the left cavernous sinus, extending into Meckel's cave with perineural spread along the mandibular branch of the left trigeminal nerve. A transsphenoidal biopsy was performed and demonstrated metastatic colon adenocarcinoma. We review the existing literature on colorectal cancer associated cavernous sinus syndrome.Conclusions and importanceCavernous sinus metastasis from colorectal cancer is exceedingly rare. We report the second case of this entity with histopathologic confirmation, and the first case with concurrent perineural spread involving the trigeminal nerve. Cavernous sinus metastasis may represent a poor prognostic factor in colorectal cancer.

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Primary T-cell lymphoblastic lymphoma of the cavernous sinus

Cited by 12 publications

References 8 publications

A Case of Tolosa-Hunt Syndrome With Discoid Lupus Erythematosus

A Case of Tolosa-Hunt Syndrome With Discoid Lupus Erythematosus

Unique case of trigeminal neuralgia due to Epstein-Barr-virus-associated B-cell lymphomatoid granulomatosis of the Meckel's cave and cavernous sinus: Important clinical and therapeutic implications

Cavernous sinus syndrome associated with metastatic colorectal cancer and perineural spread along the trigeminal nerve

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