Primary therapy for early-stage cervical cancer: radical hysterectomy vs radiation

Bansal, Nisha; Herzog, Thomas J.; Shaw, Richard E.; Burke, William M.; Deutsch, Israel; Wright, Jason D.

doi:10.1016/j.ajog.2009.06.015

Cited by 105 publications

(97 citation statements)

References 26 publications

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“…With the introduction of cervical cytological scanning and improved early diagnosis, its morbidity and mortality have significantly decreased in the past four decades (Bansal et al 2009;Kosmas et al 2009). Most cases of clinical early-stage disease (stages IA1-IIA, according to the International Federation of Gynecology and Obstetrics) are treated and cured with either hysterectomy or primary radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of cancer stem cells from cervical cancer HeLa cells

et al. 2012

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Cervical cancer is one of the most common gynecologic malignancies and poses a serious health problem worldwide. Identification and characterization of cervical cancer stem cells may facilitate the development of novel strategies for the treatment of advanced and metastatic cervical cancer. Breast cancer-resistance protein (Bcrp1)-positive cells were selected from a population of parent HeLa cells using flow cytometry. The invasion capacity of Bcrp1-positive and -negative cells was analyzed with a Boyden chamber invasion test. The tumorigenicity of these cells was determined by in vivo transplantation in non-obesity diabetes/severe combined immunodeficiency (NOD/SCID) mice. The Bcrp1-positive subpopulation accounted for about 7% of the parent HeLa cell population. The proliferative capacity of the Bcrp1-positive cells was greater than that of the Bcrp1-negative cells (P \ 0.05). In the invasion assay, the Bcrp1-positive cells demonstrated a greater invasive capacity through the artificial basement membrane than their Bcrp1-negative counterparts. Following transplantation of 10 4 cells, only the Bcrp1-positive cells formed tumors in NOD/SCID mice. When 10 5 or 10 6 cells were transplanted, the tumor incidence and the tumor mass were greater in the Bcrp1-positive groups than those in the Bcrp1-negative groups (P \ 0.05). The Bcrp1-positive subpopulation cervical cancer stem cells.

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Section: Introductionmentioning

confidence: 99%

Isolation and characterization of cancer stem cells from cervical cancer HeLa cells

et al. 2012

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“…However, the patient population with endothelial injury becomes much younger recently and the disease rate is rising. The treatment options for patients including surgical repairing, PCI or drug therapy [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…MIF is a type of cytokine which can promote tumor genesis and produced by activated T cells. It can also inhibit the migration of mononuclear and macrophage, influence the cell divides and induce malignant transformation [9]. MIF is not only limited to generate angiogenesis in tumor, but also expressed in ECM and basement membrane; rather, it is also profoundly involved in the secretion of vascular endothelial growth factor (VEGF), and even plays a critical part in carcinogenesis [10].…”

Section: Discussionmentioning

confidence: 99%

MIF Promoted Cardiovascular Angiogenesis via Erk/Mapk Pathway

Cao¹,

Fan²,

Yu³

2017

J Clin Exp Cardiolog

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As the pivotal part of cardiovascular angiogenesis, endothelial cells dysfunction is the leading cause of cardiovascular diseases. Macrophage migration inhibitory factor (MIF) is a tumor growth factor with important roles in cervical tumor formation, invasion, progression and metastasis. However, there was no report on effect of MIF on endothelial cells is unclear, and it is still unknown whether MIF is associated with angiogenesis of endothelial cells. Our study was focused on the effect of MIF and PD98059 on endothelial cells HUVEC cell line, so as to investigate the influence of MIF on expression of vascular endothelial growth factor (VEGF). We also explored whether MIF will influence angiogenesis of endothelial cells via ERK/MAPK pathways. Endothelial cells HUVEC cells were conventionally cultured, and Western blot were used to detect the expression of MIF, ERK1 and VEGF proteins after HUVEC cells were intervened by MTT and PD98059. Inter-group difference was statistically assessed. Positive expressions of MIF, ERK1 and VEGF were observed in HUVEC cells. Proliferation activity in MIF group gradually increased after 24 h, 48 h or 72 h treatment (P<0.05). Expressions of ERK1 and VEGF were increased after MIF 48 h treatment (P<0.05). Proliferation activity in PD98059 group gradually decreased after 24 h, 48 h or 72 h treatment (P<0.05). Expressions of ERK1 and VEGF were decreased after MIF 48 h treatment (P<0.05). Compared with control group, expressions of ERK1, IL-2 and VEGF were significantly decreased in both MIF pre-stimulation +PD98059 inhibition group and PD98059 pre-exposure+MIF stimulation group (P<0.05), while no difference was observed between MIF pre-stimulation+PD98059 inhibition group and PD98059 pre-exposure+MIF stimulation group (P>0.05). Expressions of ERK1 and VEGF are involved in the process of endothelial cells HUVEC cell line. MIF is correlated with increased cell proliferation and promoted cardiovascular angiogenesis via ERK/MAPK pathway

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“…The multivariate analysis showed that there was a 59% reduction in cancer-specific mortality with the performance of radical surgery and 52% reduction in overall mortality for radiotherapy. 4 Thus, radical hysterectomy was deemed superior to primary radiation because of higher survival rate and decreased morbidity. Despite its advantage (no abdominal incisions required) as well as attendant disadvantages (radiationrelated complications and higher morbidity rate), primary radiation, in this case, does not necessarily qualify as MIT.…”

Section: Treatments Without Incisions Are Not Always Mitmentioning

confidence: 99%

Robotic-assisted laparoscopy may not be a minimally invasive therapy

Lee¹

2015

Gynecology and Minimally Invasive Therapy

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Primary therapy for early-stage cervical cancer: radical hysterectomy vs radiation

Cited by 105 publications

References 26 publications

Isolation and characterization of cancer stem cells from cervical cancer HeLa cells

Isolation and characterization of cancer stem cells from cervical cancer HeLa cells

MIF Promoted Cardiovascular Angiogenesis via Erk/Mapk Pathway

Robotic-assisted laparoscopy may not be a minimally invasive therapy

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