Primary thoracic giant cell tumor of bone sensitive to steroids

Yang, Huiliang; Im, Gi Hye; Nielsen, G. Petur; Kheterpal, Arvin; Schwab, Joseph H.

doi:10.1007/s00256-018-2911-y

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…We reviewed studies on aggressive GCT published over the past 20 years according to PRISMA statement, and 52 studies were involved ( Figure 10 ). 15 - 66 There were 60 patients with 53 CT scans and 39 MRI scans, of whom 21 patients underwent enhanced scans simultaneously. The typical and atypical features were summarized according to the diagnostic standards in the present study ( Table 2 ) and the frequency of the features was similar.…”

Section: Resultsmentioning

confidence: 99%

Imaging Features of Aggressive Giant Cell Tumors of the Mobile Spine: Retrospective Analysis of 101 Patients From Single Center

Yuan

Zhang

Yang

et al. 2021

Global Spine Journal

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Study Design: Retrospective study. Objectives: Giant cell tumors (GCTs) of the mobile spine can be locally aggressive. This study described and classified the typical and atypical appearance of aggressive spinal GCTs according to imaging findings to help the imaging diagnosis, especially for patients with rapid neurological deficit that may require emergent surgery without biopsy. Methods: Computed tomography (CT) and magnetic resonance imaging (MRI) scans of patients diagnosed with aggressive spinal GCTs at single center were reviewed. Results: Overall, 101 patients with 100 CT images and 94 MR images were examined. All lesions were osteolytic with cortical destruction; 95 lesions showed epidural extension; 90 were centered in the vertebral body; 82 showed pathological fracture and/or collapse of the vertebral body; 78 had pseudotrabeculation on CT; 80 showed low-to-iso signal intensity or heterogeneous high-signal intensity with cystic areas on the T2-weighted images; 9 showed fluid–fluid level on T2-weighted images; and 61 patients showed marked enhancement on contrast-enhanced CT and/or MRI. Forty-one lesions (40.6%) had at least 1 atypical radiographic feature: 19 involved ≥2 segments; 11 were centered in the posterior neural arch; 10 had a paravertebral mass over 2 segments; 16 showed partial margin sclerosis with partial cortical destruction on CT scans; and 3 showed mineralization within the tumor on CT. Eighty-eight patients underwent CT-guided biopsy with a diagnostic accuracy rate of 94.3%. Conclusions: Spinal GCTs might appear more radiologically atypical, and about 40% of the lesions may have at least 1 atypical feature. CT-guided biopsies are recommended for definitive diagnosis.

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Section: Resultsmentioning

confidence: 99%

Imaging Features of Aggressive Giant Cell Tumors of the Mobile Spine: Retrospective Analysis of 101 Patients From Single Center

Yuan

Zhang

Yang

et al. 2021

Global Spine Journal

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18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of spinal giant cell tumors

et al. 2020

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Giant Cell-Rich Tumors of the Skeleton

Diaz-Perez,

Rosenberg

2024

Advances in Anatomic Pathology

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The accurate diagnosis of giant cell-rich tumors of bone is challenging, especially in limited tissue samples. This diverse group of neoplasms have similar and often ambiguous clinical presentations, radiologic features, and morphologic characteristics. During the last decade, the discovery of pathogenic recurrent genetic alterations has allowed the development of immunohistochemical surrogate markers and FISH assays that can help differentiate the entities of this broad group from one another. The correct diagnosis of these neoplasms is essential in the management of the affected patients.

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Primary thoracic giant cell tumor of bone sensitive to steroids

Cited by 3 publications

References 25 publications

Imaging Features of Aggressive Giant Cell Tumors of the Mobile Spine: Retrospective Analysis of 101 Patients From Single Center

Imaging Features of Aggressive Giant Cell Tumors of the Mobile Spine: Retrospective Analysis of 101 Patients From Single Center

18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of spinal giant cell tumors

Giant Cell-Rich Tumors of the Skeleton

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