Primary thrombophilia in Mexico IX

Ruíz‐Argüelles, Guillermo J.; Garcés‐Eisele, Javier; Camacho-Alarcón, Cecilia; Reyes-Núñez, Virginia; Moncada-González, Benjamín; Valdés-Tapia, Patricia; León-Montes, Nancy; Ruíz-Delgado, Guillermo J.

doi:10.1177/1076029612448418

Cited by 16 publications

(8 citation statements)

References 30 publications

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“…During a 324-month period, all consecutive mestizo Mexican patients referred to our center by physicians from different parts of the country were prospectively enrolled if they had one of the following clinical markers related to a primary hypercoagulable state [ 6 , 7 , 8 , 9 , 10 , 11 ]: a) thrombosis at age younger than 40 years; b) family history of thrombosis (first-degree relatives); c) recurrent thrombosis without apparent triggering factors; d) thrombosis at uncommon anatomic locations; or e) resistance to conventional antithrombotic therapy. Patients with overt malignancy, puerperium, pregnancy, use of oral contraceptives, or other conditions related to secondary thrombophilia were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Sticky platelet syndrome (SPS) was first described by Holliday et al [ 1 ] at the 9 th Conference on Stroke and Cerebral Circulation in Arizona in 1983. Since then, we and others have found that SPS is a common cause of arterial and venous thrombosis [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. SPS is the second most common hereditary thrombophilic condition after resistance to activated protein C and the most common thrombophilia associated with arterial thrombosis, with an incidence of 21% [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Primary thrombophilia in México XII: Miscarriages are more frequent in persons with the Sticky Platelet Syndrome (SPS)

Ruíz-Delgado¹,

Cantero-Fortiz²,

Méndez-Huerta³

et al. 2017

Tjh

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Objective:Sticky platelet syndrome (SPS) is an inherited condition that leads to arterial and venous thrombosis. There is scant information about the association between SPS and obstetric complications. This study aimed to assess the relationship between SPS and fetal loss at a single institution.Materials and Methods:The obstetric histories of all consecutive female patients prospectively studied in a 324-month period at a single institution with a history of thrombosis and a clinical marker of primary thrombophilia were reviewed.Results:Between 1989 and 2016, 268 consecutive patients with a clinical marker of primary thrombophilia and a history of arterial or venous thrombosis were studied; of these, 108 were female patients. Within this subset of thrombophilic females, 77 (71%) had been pregnant at some point. Twenty-eight of these 77 patients (37%) had had a spontaneous abortion and 24 of those (86%) were found to have SPS. On the other hand, in a subset of 73 female patients with SPS who had been pregnant, 32% had miscarriages. These figures are significantly higher than the prevalence of spontaneous abortions in the general Mexican population of pregnant women, which is 12%-13% (chi-square: 7.47; p=0.0063). Accordingly, the relative risk of having a miscarriage is 2.66 times higher in female patients with SPS than in the general population (p=0.0014).Conclusion:In Mexico, female patients with SPS experience significantly more spontaneous abortions than the general population. Since the treatment of SPS is simple and effective and could in turn prevent adverse obstetric outcomes, its investigation in women treated for obstetric complications may be useful and deserves further research.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary thrombophilia in México XII: Miscarriages are more frequent in persons with the Sticky Platelet Syndrome (SPS)

Ruíz-Delgado¹,

Cantero-Fortiz²,

Méndez-Huerta³

et al. 2017

Tjh

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“…Sokol et al showed a significantly increased incidence of these GP6 polymorphisms in SPS patients with miscarriages [20]. Furthermore, Ruiz–Argüelles et al analyzed the glycoprotein IIIa PI A1/A2 polymorphism in conjunction with the SPS, but no significant association was found [46]. Sokol et al investigated SPS patients with miscarriages and controls for genetic polymorphism and Gas6/PEAR1 gene polymorphisms could be described [16].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss

Yagmur¹,

Bast

Mühlfeld

et al. 2019

JCM

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Platelet hyperaggregability, known as sticky platelet syndrome (SPS), is a prothrombotic disorder that has been increasingly associated with pregnancy loss. In this retrospective study, we aimed to investigate the clinical and diagnostic relevance of SPS in 208 patients with infertility and unexplained pregnancy loss history. We studied 208 patients that had been referred to undergo a dose-dependent platelet aggregation response to adenosine diphosphate and epinephrine using light transmission aggregometry modified by Mammen during an 11-year period. Patients’ platelet aggregation response was compared with platelet function in 29 female healthy controls of fertile age with no previous history of pregnancy loss. We found a prevalence of SPS type II (33.2%) in 208 female patients with infertility and pregnancy loss. ∆-epinephrine-induced platelet aggregation in patients with SPS was significantly decreased (median 7% and range −21 to 43%) compared to patients without SPS (median 59%, range 7–88% and p < 0.0001) and healthy controls (median 57%, range 8–106% and p < 0.0001). The optimum SPS-diagnostic cutoff value for ∆-epinephrine aggregation was ≤32% (sensitivity 95.7%, specificity 95.2%). SPS patients with low-dose acetylsalicylic acid (ASA) therapy (n = 56) showed improved pregnancy outcome (32 pregnancies; live births n = 18 (56%)) compared to SPS patients without low-dose ASA (n = 13) (3 pregnancies; live births n = 1 (33%)). Our study demonstrates the clinical and diagnostic relevance of platelet hyperaggregation in women with infertility and pregnancy loss history. Further studies should investigate the potential of SPS as a novel decisional tool with both diagnostic and clinical implications in infertility and pregnancy loss.

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“…Although there have been multiple studies, to date, it has not been possible to find a genetic alteration that explains this syndrome. Different membrane protein polymorphisms have been studied, such as mutations in GPIIIaPlA A1/A2 and in Gas6 c. 834 + 7G>A, in which no statistically significant difference was found between the groups with SPS and controls [ 17 , 18 ]. However, some polymorphisms of GP6 SNPs have been shown to be present more frequently in cases of SPS [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss

Solis-Jimenez

Hinojosa-Heredia

García-Covarrubias

et al. 2018

Case Reports in Nephrology

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Introduction Sticky platelet syndrome (SPS) is a prothrombotic disease that is not well recognized and difficult to diagnose. Case Report We present a case of a 49-year-old diabetic woman on ambulatory peritoneal dialysis therapy who underwent a kidney transplant from living-related donor. The donor was her sister with whom she shared one haplotype and absence of donor specific antibodies. The posttransplant evolution was torpid, developing progressive deterioration, which made us suspect a failure in the graft. Doppler ultrasound reported renal vein thrombosis and hypoperfusion of the renal artery. Without clinical improvement, she required a reintervention that ended in graftectomy, in which the histopathological report showed negative C4d with medullary and cortical infarction. Hematological studies were negative for antibodies against phospholipids, with correct levels of proteins C and S and antithrombin. Platelet aggregometry studies were carried out, which were compatible with SPS. Conclusions Recognition of SPS in pretransplant studies is difficult if there is no history of previous thrombotic events. However, we must consider this entity in cases of acute thrombosis and loss of the graft of uncertain origin.

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Primary thrombophilia in Mexico IX

Abstract: In Mexican mestizo patients, the platelet GP IIIa PL(A1/A2) gene polymorphism does not lead to the SPS phenotype.

Cited by 16 publications

References 30 publications

Primary thrombophilia in México XII: Miscarriages are more frequent in persons with the Sticky Platelet Syndrome (SPS)

Primary thrombophilia in México XII: Miscarriages are more frequent in persons with the Sticky Platelet Syndrome (SPS)

High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss

Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss

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