Primary Thrombophilia in Mexico XII: Miscarriages Are More Frequent in Persons with the Sticky Platelet Syndrome (SPS)

Abstract

Background: The sticky platelet syndrome (SPS) is an inherited condition which leads into arterial and venous thrombosis. There is scant information about the association between the SPS and obstetric complications. Objective: To assess the relationship of the SPS and fetal loss in a single institution. Material and methods: The obstetric history of all the consecutive female patients prospectively studied along a 324 month period, in a single institution with a history of thrombosis and a clinical marker of primary thrombophilia was reviewed. Results: Between 1989 and 2016, 268 consecutive patients with a clinical marker of primary thrombophilia and a history of arterial or venous thrombosis were studied; of these, 108 were female patients. Within this subset, 77 (71%) had been pregnant at some moment. Twenty eight of these 77 patients (37%) had had an abortion and 24 out of these (86%) were found to have the SPS. On the other hand, in a subset of 73 female patients with the SPS who had been pregnant, 32% had miscarriages (14 had one abortion, 5 two abortions and 4 three or more abortions). These figures are significantly higher than the prevalence of abortions in the Mexican general population of pregnant women, which is 12-13% (chi square = 7.47; p = 0.0063). Accordingly, the relative risk of having a miscarriage is 2.66 times higher in female patients with the SPS than in the general population (p = 0.0014 ). Conclusion: In México, female patients with the SPS experience significantly more miscarriages than the general population. Since the treatment of the SPS is simple and effective and could in turn prevent adverse obstetric outcomes, its investigation in women studied because obstetric complications may be useful and deserves further research. Disclosures No relevant conflicts of interest to declare.

Professor Peter Kubisz (1942–2022)—Un hommage à trois étincelles

“…As a result of our interest in the SPS and with the assistance of various collaborators and of the previously mentioned giant clotters, we have now pieced several features of the SPS which can be summarized as follows 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 :…”

Two observations of the hematology of women

“…Miscarriages in Mexico occur in 12-13% of healthy women 3 . This figure goes up to 32% in women with the sticky platelet syndrome (SPS), a statistically significant difference.…”

“…This figure goes up to 32% in women with the sticky platelet syndrome (SPS), a statistically significant difference. The SPS has been recognized as the most frequent cause of recurrent fetal loss in our country 3 , more frequent than even other autoimmune or infectious conditions, such as antiphospholipid syndrome or infections by toxoplasma, rubella, cytomegalovirus, or herpes 3 . The proper identification of SPS followed by appropriate treatment leads into the course of successful pregnancies in these women, provided they are given antiplatelet drugs, mainly aspirin, throughout the whole pregnancy.…”