Primary Thyroid-Like Follicular Renal Cell Carcinoma: An Emerging Entity

Malde, Sachin; Sheikh, Ishfaq Ahmad; Woodman, Isabel; Fish, David E.; Bilagi, P.; Sheriff, M. K. M.

doi:10.1155/2013/687427

Cited by 16 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tumour size is variable, ranging from 11 to 118 mm in the greatest dimension. Thyroid‐like follicular carcinoma of the kidney usually follows a non‐aggressive and indolent clinical course, although several patients with metastases in the regional lymph nodes, lung, retroperitoneum, skull and meninges have been reported …”

Section: Thyroid‐like Follicular Carcinoma Of the Kidneymentioning

confidence: 99%

“…Thyroid-like follicular carcinoma of the kidney usually follows a non-aggressive and indolent clinical course, although several patients with metastases in the regional lymph nodes, lung, retroperitoneum, skull and meninges have been reported. [31][32][33][34][35][36] Grossly, thyroid-like follicular carcinoma of the kidney appears well-circumscribed and encapsulated, and the cut surface is tan-brown to dark brown. On microscopy, there is a distinct follicular pattern and thyroid-like morphology, with variable-size follicles filled with colloid-like content, resembling follicular carcinoma of the thyroid (Figure 2A-F).…”

Section: Thyroid-like Follicular Carcinoma Of the Kidneymentioning

confidence: 99%

See 1 more Smart Citation

New and emerging renal entities: a perspective post‐WHO 2016 classification

2018

View full text Add to dashboard Cite

Renal tumours include a heterogeneous and diverse spectrum of neoplasms. Recent advances in this field have significantly improved our understanding of the morphological, immunohistochemical, molecular, epidemiological and clinical characteristics of renal tumours, which led to the new Vancouver classification of renal neoplasia and the new World Health Organization (WHO) classification of renal cell tumours. This review aims to summarise the new information and evidence on several new and emerging/provisional renal entities, which were mostly generated after the recent classification of renal neoplasia. We include in this review the following new and emerging/provisional renal entities: succinate dehydrogenase‐deficient renal cell carcinoma, thyroid‐like follicular carcinoma of the kidney, anaplastic lymphoma kinase rearrangement‐associated renal cell carcinoma, renal cell carcinomas with prominent smooth muscle stroma, fumarate hydratase‐deficient renal cell carcinoma, biphasic squamoid papillary renal cell carcinoma, eosinophilic solid and cystic renal cell carcinoma, atrophic kidney‐like renal cell carcinoma, clear cell renal cell carcinoma with giant cells and emperipolesis, Warthin‐like papillary renal cell carcinoma, and low‐grade oncocytic renal tumour (CD117‐negative; cytokeratin 7‐positive). Some of these entities, such as succinate dehydrogenase‐deficient renal cell carcinoma, have already been recognised as new entities in the WHO classification, and some have been recognised as provisional/emerging entities. However, we include in this review several additional entities that, on the basis of the published evidence, also warrant this designation. We hope that this review will ease the navigation through this complex and evolving field, and will inform and stimulate new studies and discussions.

show abstract

Section: Thyroid‐like Follicular Carcinoma Of the Kidneymentioning

confidence: 99%

Section: Thyroid-like Follicular Carcinoma Of the Kidneymentioning

confidence: 99%

New and emerging renal entities: a perspective post‐WHO 2016 classification

2018

View full text Add to dashboard Cite

show abstract

“…PET scan: mild FDG uptake.T/post op therapy with sunitinib for lung metastases. No FU data.Malde 2013 (19)29 FFlank painThyroid normal (F)L LP, 58(CT) Complex multiseptated partially cystic, low attenuation, no enhancement. (MRI) no enhancement.T.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Thyroid-like follicular carcinoma of the kidney presenting on a ten year-old prepubertal girl

et al. 2019

View full text Add to dashboard Cite

The very rare thyroid-like carcinoma of the kidney (TLCK) is microscopically similar to thyroid follicular cell carcinoma (TFCC). Differential diagnosis with secondary thyroid tumors depends on non-reactivity to immunohistochemical (IHC) markers for TFCC (thyroglobulin - TG and TTF1). We herein describe the fourth Pediatric case in literature and extensively review the subject. Only 29 cases were published to the moment. Most cases were asymptomatic and incidentally detected. Most tumors are hyperechoic and hyperdense with low grade heterogenous enhancement on CT and MRI. Most patients were treated with radical nephrectomy, but partial nephrectomy was used in some cases, apparently with the same results. Metastases are uncommon and apparently do not change prognosis, but follow-ups are limited. Up to the moment, TLCK presents as a low grade malignancy that may be treated exclusively with surgery and frequently with partial kidney renal preservation. A preoperative percutaneous biopsy is a common procedure to investigate atypical tumors in childhood and adult tumors. To recognize the possibility of TLCK is fundamental to avoid unnecessary thyroidectomies in those patients, supposing a primary thyroid tumor.

show abstract

“…Additional case reports appeared in the literature [6-10], all but one describing tumors with follicular morphology, composed of cells with moderate amphophilic to slightly eosinophilic cytoplasm creating macro and microfollicles containing inspissated colloid-like material, with only small amount of packed follicles devoid of secretions. One of two cases described by Alessandrini et al [9], however showed focal papillary arhitecture, without nuclear grooving or optical clearing.…”

Section: Discussionmentioning

confidence: 99%

Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report

2013

View full text Add to dashboard Cite

Thyroid-like follicular carcinoma of the kidney (TLFC), a rare neoplasm with low malignant potential, is histologically similar to primary thyroid follicular carcinoma, but characteristically lacks thyroid immunohistochemical markers. We report a case of 34-year old patient with nephrolithiasis. Ultrasound revealed hepatorenal cysts consistent with adult type polycystic kidney disease (ATPKD) and a cytologically confirmed left kidney tumor. Nephrectomy specimen contained sharply demarcated lesion of unusual morphology. Tubular and cystic structures lined by mostly cuboidal cells and filled with amorphous eosinophillic material, reminiscent of follicular carcinoma of the thyroid gland, were diagnostic for TLFC. Thyroid markers were negative. To our knowledge this is the first report of TFLC associated to ATPKD. Brief review of previously published TFLCs, possible relationship between entities and differential diagnosis are discussed.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8067946569612694

show abstract

Primary Thyroid-Like Follicular Renal Cell Carcinoma: An Emerging Entity

Cited by 16 publications

References 12 publications

New and emerging renal entities: a perspective post‐WHO 2016 classification

New and emerging renal entities: a perspective post‐WHO 2016 classification

Thyroid-like follicular carcinoma of the kidney presenting on a ten year-old prepubertal girl

Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report

Contact Info

Product

Resources

About