Primary Thyroid Mucoepidermoid Carcinoma (MEC) Is Clinically, Prognostically, and Molecularly Different from Sclerosing MEC with Eosinophilia: A Multicenter and Integrated Study

Le, Hieu Trong; Nguyen, Truong Phan Xuan; Hirokawa, Mitsuyoshi; Katoh, Ryohei; Mitsutake, Norisato; Matsuse, Michiko; Sako, Ayaka; Kondo, Tetsuo; Vasan, Nilesh; Kim, Young Mi; Liu, Ying; Hassell, Lewis; Kakudo, Kennichi; Vuong, Huy Gia

doi:10.1007/s12022-022-09741-1

Cited by 10 publications

(3 citation statements)

References 78 publications

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“…To better understand the pathogenesis of MEC in salivary versus extra-salivary origins, researchers have compared the molecular profile of primary breast MECs with salivary and extra-salivary MECs ( 33 ). Primary MEC in the salivary gland and lung have been found to be associated with MAML2 fusion ( 34 , 35 ), however, the pathogenesis of primary thyroid MEC seems to be MAML2-independent ( 36 ). Among the reported cases of breast MEC that have been investigated for presence of MAML2 rearrangements, three have presented with the feature, suggesting a need for the classification of more tumors ( 1 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma—a rare salivary gland-type tumor of the breast: are we dealing with primary or secondary?—a case report and literature review

Zhang,

Bhimani,

Lanjewar

et al. 2024

Gland Surg

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Background Salivary gland-like tumors are extremely unusual in the breast, and their histology is very similar to primary salivary gland neoplasms. Mucoepidermoid carcinoma (MEC), a common salivary gland tumor, displays an infrequent occurrence in the breast, accounting for a mere 0.2–0.3% incidence. Given its rarity, it is critical to accurately distinguish it from metastatic cases before diagnosing it as a primary breast MEC for appropriate treatment. Currently, there is no consensus on the treatment of MEC, and there is a paucity of literature highlighting the ideal treatment modality, especially for estrogen receptor (ER)-positive cancers. Therefore, the aim of our case report was to underscore the diagnostic process, surgical and adjunctive treatments for our patient with ER-positive, progesterone receptor (PR)-negative and human epidermal growth factor receptor 2 (HER2)-negative MEC while also conducting a literature review to contribute to the limited existing data. Case Description A 67-year-old African American woman presented with a lobulated 3.1-cm left breast mass on mammography, for which she underwent ultrasound-guided core needle biopsy that revealed invasive carcinoma with squamous differentiation. The carcinoma was ER-positive, PR-negative and HER2-negative. Subsequently, she underwent a lumpectomy with sentinel lymph node biopsy. Her final pathology revealed an intermediate-grade MEC with negative lymph nodes. She had a past medical history of benign salivary gland tumor, as well as a family history of BReast CAncer gene 1 ( BRCA1 )-associated breast cancer in her daughter. Conclusions MEC of the breast is a rare tumor with a relatively favorable overall prognosis. The early and precise diagnosis of this condition plays a pivotal role in formulating effective treatment strategies and ensuring positive survival rates. Nonetheless, future studies are recommended to further explore the role of surgical approaches and adjuvant therapy to improve treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma—a rare salivary gland-type tumor of the breast: are we dealing with primary or secondary?—a case report and literature review

Zhang,

Bhimani,

Lanjewar

et al. 2024

Gland Surg

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“…While being one of the most common malignant tumors derived from salivary gland tissue, primary thyroid MEC is an extremely rare and often poorly understood tumor, accounting for less than 0.5% of primary thyroid neoplasms [1,2]. Approximately 60 cases have been reported [25] since the first primary thyroid MEC patient was presented by Rhatigan in 1978 [8].…”

Section: Discussionmentioning

confidence: 99%

“…Generally, MEC arising in the thyroid is associated with an indolent clinical evolution and a favorable prognosis and usually presents as a solitary thyroid nodule, prompting evaluation [47,48]. A recent literature review on this topic [25] showed that thyroid MECs typically occur in elderly patients, mostly in men. Chronic lymphocytic thyroiditis was present in 42% of cases, while concurrent thyroid neoplasms were documented in more than 50%.…”

Section: Discussionmentioning

confidence: 99%

Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement

Mitrache,

Terzea,

Sirbu

et al. 2024

Biomedicines

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Mucoepidermoid carcinomas (MECs) represent the most common malignant neoplasms of the salivary glands, but they have also been described in other unusual sites. Primary MECs originating in the thyroid gland are exceedingly rare, accounting for less than 0.5% of thyroid tumors. Owing to their low to medium grade, they are usually associated with an indolent evolution and a good long-term prognosis, generally being managed surgically based on the extent of the disease. However, this does not always apply, as primary thyroid MECs may present as metastatic or locally advanced diseases. While several treatment options have been explored in such cases, no consensus currently exists on their optimal treatment plan, and they should be managed in a multidisciplinary fashion. We report the case of a 67-year-old patient with primary MEC of the thyroid, which behaved aggressively, with extensive pulmonary metastasis, ultimately leading to the rapid clinical deterioration and death of the patient.

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Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma

et al. 2023

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Primary Thyroid Mucoepidermoid Carcinoma (MEC) Is Clinically, Prognostically, and Molecularly Different from Sclerosing MEC with Eosinophilia: A Multicenter and Integrated Study

Cited by 10 publications

References 78 publications

Mucoepidermoid carcinoma—a rare salivary gland-type tumor of the breast: are we dealing with primary or secondary?—a case report and literature review

Mucoepidermoid carcinoma—a rare salivary gland-type tumor of the breast: are we dealing with primary or secondary?—a case report and literature review

Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma

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