Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients

Abstract

BackgroundThis retrospective study was designed to investigate the clinical characteristics, diagnosis, treatment and prognosis of primary tracheobronchial mucoepidermoid carcinoma (MEC).MethodsClinical data were retrospectively analyzed from 32 patients with pathologically confirmed primary tracheobronchial MEC between January 1990 and December 2010 at Zhejiang Cancer Hospital. The Kaplan-Meier methods were used to estimate and compare survival rates.ResultsThere were 19 males and 13 females ranging in age from 7 to 73 years, with a median age of 28 years. Twenty-six of the 32 patients were treated with surgery alone. The other six patients were treated with surgery plus postoperative radiotherapy or chemotherapy. Six patients died during the follow-up time. The overall five-year survival rates were 81.25%, whereas the five-year survival rate of seven patients with high-grade tumors was only 28.6%. Stage I and II patients experienced better survival than Stage III and IV patients (the five-year survival rate was 100% and 43.6% respectively, P<0.001).ConclusionsPrimary tracheobronchial MEC is a rare disease. Histologic grading and TNM (tumor-node-metastasis)staging are independent prognostic factors. Surgical resection is the primary treatment.

Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases

“…Furthermore, although the numbers of patients were limited in previous studies [8–12, 21, 22, 30], it is easy to observe the trend that the average age of the patients was related to the tumor grade. In our study, we focused on elderly patients of >65 years of age and analyzed the prognostic factors influencing DFS and OS.…”

A case of mucoepidermoid carcinoma of the bronchus presented with hydropneumothorax in a child

“…Primary mucoepidermoid carcinoma (MEC) of the tracheobronchial airway is a rare childhood tumor, with fewer than 100 cases reported worldwide and constituting only 0.1–0.2% of primary lung malignancies . In the present study, we report bronchial MEC in a 12‐year‐old boy manifesting pneumothorax.…”

Bronchial Mucoepidermoid Carcinoma Successfully Treated with Radiation Therapy: A Case Report

“…In their cox regression analysis, histological grade and TNM stage and resectability were significantly associated with prognosis. Other reports described grade and operability as meaningful factors of prognosis [4,20]. In another report, age was also reported as a prognostic factor [22].…”

“…A few advanced bronchial MEC cases have been treated as NSCLC in clinical practice [4,14]. We summarized the papers reporting on the treatment and prognosis of pulmonary MEC (Table 1) [15][16][17][18][19][20][21][22][23][24][25][26]. Chin and colleagues examined 41 cases of surgical treatment and reported that 5-year survival rate of high-grade MEC was 53.2% and 5-year survival rate of low grade MEC was 66.7% [17].…”