Primary tuberculous osteomyelitis of the mandible

Nwoku, L.; Kekere-Ekun, Tajudeen A.; Sawyer, Danny R.; Olude, O.

doi:10.1016/s0301-0503(83)80011-3

Cited by 25 publications

(18 citation statements)

References 9 publications

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“…To our knowledge, only three cases have been documented and the youngest patient was a 6-year-old boy. [4][5][6] As infectious route to the mandibular bone, three routes could be considered. One is direct transfer of infected sputum or infected raw milk through a carious tooth, a postextraction socket and mucosal wound.…”

Section: Discussionmentioning

confidence: 99%

“…1-6 However, primary tuberculous osteomyelitis of the mandible is extremely rare. [4][5][6] We present a case of a 3-year-old boy with primary tuberculous osteomyelitis of the mandible. He complained of a left submandibular mass.…”

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confidence: 99%

“…Although pulmonary lesions are usual, those of extrapulmonary tuberculosis have reportedly increased. [1][2][3][4][5][6] However, primary tuberculous osteomyelitis of the mandible is extremely rare. [4][5][6] We present a case of a 3-year-old boy with primary tuberculous osteomyelitis of the mandible.…”

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confidence: 99%

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Primary tuberculous osteomyelitis of the mandible

Imamura

Kakihara

Yamamoto

et al. 2004

Pediatrics International

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Tuberculosis is a chronic infectious granulomatous disease caused by Mycobacterium tuberculosis and less frequently by Mycobacterium bovis. Although pulmonary lesions are usual, those of extrapulmonary tuberculosis have reportedly increased. 1-6 However, primary tuberculous osteomyelitis of the mandible is extremely rare. [4][5][6] We present a case of a 3-year-old boy with primary tuberculous osteomyelitis of the mandible. He complained of a left submandibular mass. Radiographic examination revealed osteolytic lesions in the left mandibular angle, the left scapula and the left ulna. A biopsy from the mandible showed non-caseating epithelial granuloma. The mandibular mass spontaneously regressed in a month without definitive diagnosis. Swelling of the bilateral mandibular body was found 2 years later. He was diagnosed as having tuberculous osteomyelitis by culture study and treated with isoniazid and rifampicin without recurrence. Here we stress the importance of considering tuberculous osteomyelitis in the differential diagnosis of jaw lesions to prevent serious systemic spread. Case reportA 3-year-old Japanese boy was admitted to a local hospital with a complaint of a bean-sized subcutaneous mass in the neck. Microscopic examination of the resected subcutaneous mass showed non-caseating epithelioid cell granulomas without definitive diagnosis. Ziehl-Neelsen staining for mycobacterium and culturing of this material were not performed. He developed swelling of the left mandible 1 month later, and was administered antibiotics including ampicillin-sulbactam, cefmetazole, aspoxicillin, ceftizoxime and minocycline without improvement.He was then referred to Niigata University Medical & Dental Hospital for further evaluation. He did not have underlying primary immune deficiency. It was established that Bacillus Calmette Guerin vaccination had been given at the age of 3 months and there had been no contact with tuberculosis patients. In his family there was no history of tuberculosis either. At presentation, a firm, non-tender and immovable mass measuring 5 cm in diameter was observed in the left mandiblar angle. A thumb-sized submandibular lymph node was also found. Hepatosplenomegaly was not found. Radiographic study revealed irregular osteolytic findings in the left mandibular angle. Osteolytic lesions were also found in the left scapula and the proximal metaphysis of the left ulna. Sclerotic change was found in the left orbital bone. Chest roentgenography revealed no findings suggestive of tuberculosis. Computed tomography revealed bone destruction and new bone formation in the left ramus (Fig. 1). A technetium ( 99m TcMDP) scan showed increased activity in the left mandibular bone, left scapula, left proximal ulna, and bilateral pelvis (Fig. 2). A gallium ( 67 Ga) scan showed increased activity only in the left mandibular bone. Laboratory findings showed white blood cell count of 9400/mm 3 , red blood cell count of 485 × 10 4 /mm 3 , hemoglobin of 9.7 g/dL, hematocrit of 31.6%, platelet count of 44.2 × 10 4 /mm 3 ...

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Section: Discussionmentioning

confidence: 99%

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Primary tuberculous osteomyelitis of the mandible

Imamura

Kakihara

Yamamoto

et al. 2004

Pediatrics International

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“…It usually involves gingival and is associated with caseation of the dependent lymph nodes; the lesion itself remains painless in most cases. [2] In contrast, secondary oral tuberculosis is common and is usually seen in older adults. [3] The most commonly affected site is the tongue, followed by palate, lips, buccal mucosa, gin-giva, and frenulum.…”

Section: Introductionmentioning

confidence: 99%

Primary gingival tuberculosis: A rare clinical entity

2011

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Tuberculosis is a specific granulomatous infectious disease and a major cause of death in developing countries. Primary gingival tuberculosis is extremely rare and forgotten entity. Oral lesions usually appear as secondary to primary tuberculosis infection elsewhere. The lesion may take the form of nodules, ulcers, or elevated fissures. We report a case of primary tuberculosis of gingiva, manifesting as gingival enlargement with ulceration and discharge. Diagnosis was based on histopathologic examination, complete blood count, chest X-ray, and immunologic investigations with detection of antibodies against Mycobacterium tuberculosis. With the recent increase in the incidence of tuberculosis, this case report also emphasizes the need for clinicians to be aware of this possibility, consider tuberculosis in the differential diagnosis of gingival enlargement, and thus, play a role in the early detection of this disease.

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“…It usually involves gingival and is associated with caseation of the dependent lymph nodes; the lesion itself remains painless in most cases. 3 In contrast, secondary oral tuberculosis is common and is usually seen in older adults. 4 The most commonly affected oral site is the tongue followed by palate, lips, buccal mucosa, gingiva and the frenulum.…”

Section: Introductionmentioning

confidence: 99%

Gingival Tuberculosis - A Rare Presentation

Akhtar

Talha

Haiyat

et al. 2018

AAMS

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Tuberculosis is a specific granulomatous infectious disease and a major cause of morbidity and mortality in the developing countries. Primary gingival tuberculosis is extremely rare and is often a forgotten entity. It usually manifests as an ulcer. Oral lesions usually appear as a secondary form of infection. We report a case of primary tuberculosis in a 22 year old female who presented to the dental out-patients department with complaints of diffuse gingival enlargement. The patient had no evidence of tuberculosis anywhere else in the body. The possibility of gingival enlargement due to drugs, leukemia, fungus and sarcoidosis was ruled out. Histopathology of the resected mass showed caseating epithelioid granulomas. Anti-tubercular therapy comprising of 4 drug regimen was administered. On follow up after 6 months, there was no recurrence of the disease. This case emphasizes the need for dental surgeons to include tuberculosis in the differential diagnosis of gingival enlargement for early detection of this highly infectious disease.

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Primary tuberculous osteomyelitis of the mandible

Cited by 25 publications

References 9 publications

Primary tuberculous osteomyelitis of the mandible

Primary tuberculous osteomyelitis of the mandible

Primary gingival tuberculosis: A rare clinical entity

Gingival Tuberculosis - A Rare Presentation

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