Primary Tumor Maximum Standardized Uptake Value Measured on<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Is a Prognostic Value for Survival in Bile Duct and Gallbladder Cancer

Lee, Ji Yong; Kim, Hong Joo; Yim, Seo Hyung; Shin, Doosup; Yu, Jeong Sik; Ju, Deok Yun; Park, Jung Ho; Park, Dong Il; Cho, Yong Kyun; Sohn, Chong Il; Jeon, Woo Kyu; Kim, Byung Ik

doi:10.4166/kjg.2013.62.4.227

Cited by 18 publications

(9 citation statements)

References 24 publications

(33 reference statements)

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“…There are a limited number of previous studies that have assessed factors to predict cholangiocarcinoma prognosis based on 18 F-FDG PET/CT. Lee et al reported that SUV max of the primary tumor was an independent and significant prognostic factor for overall survival in bile duct and gallbladder cancer [12]. Park et al reported that preoperative SUV max of the primary tumor was significantly associated with recurrence in patients with biliary tract cancer [13].…”

Section: Discussionmentioning

confidence: 99%

“…Positron emission tomography (PET) using 18 F-fluoro-2deoxy-D-glucose ( 18 F-FDG) is a useful tool for predicting prognosis in many kinds of malignancies [7][8][9][10]. In addition, several studies have reported that metabolic parameters derived from 18 F-FDG PET/CT might be useful for predicting prognosis in biliary tract malignancies [11][12][13][14]. These studies, however, included patients with various types of hepatobiliary cancers, such as intrahepatic cholangiocarcinoma or gall bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

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Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

Park

Bae

et al. 2018

Nucl Med Mol Imaging

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Purpose As there were few previous studies with a small number of subjects, the purpose of this was to evaluate the prognostic significance of 18 F-FDG PET/CT in patients with distal bile duct cancer undergoing curative surgery. Methods The study included 40 patients (M/F = 24:16; age 68.0 ± 8.0 years) who underwent preoperative 18 F-FDG PET/CT followed by curative surgical resection. The participant's age, sex, Eastern Cooperative Oncology Group performance-status score, baseline serum CA 19-9 level, stage, pathologic T and N stages, tumor size, tumor grade, tumor growth pattern, R0 resection, and adjuvant therapy were included as clinicopathological variables for predicting overall survival. The PET variables were maximum standardized uptake value (SUV max), average SUV (SUV avg), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the tumor. The Kaplan-Meyer method and Cox proportional hazards model were used for the survival analysis. Results A total of 15 of 40 patients (37.5%) died during the follow-up period. In univariate analysis, low SUV max (≤ 2.7, p = 0.0005) and low SUV avg (≤ 2.6, p = 0.0034) were significant predictors of poor overall survival. In multivariate analyses, only low SUV max (HR = 6.7016, 95% CI 1.9961-22.4993, p = 0.0047) was an independent prognostic factor associated with poor overall survival. Conclusion The SUV max of the primary tumor measured by 18 F-FDG PET/CT was an independent significant prognostic factor for overall survival in patients with distal bile duct cancer. However, different results from a previous study warrant further large sample-sized study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

Park

Bae

et al. 2018

Nucl Med Mol Imaging

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“…CCa has a poor prognosis and surgical resection with appropriate lymph node dissection is advocated as the curative approach in some patients [2]. Consequently, accurate evaluation and staging are critical to provide indication to surgery and to avoid unnecessary surgical interventions [3].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Evaluation of the Primary Tumor in Patients with Cholangiocarcinoma: A Meta-Analysis

Annunziata

Caldarella

Pizzuto

et al. 2014

BioMed Research International

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Objective. To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for primary tumor evaluation in patients with cholangiocarcinoma (CCa). Methods. A comprehensive literature search of studies published through December 31, 2013, was performed. Pooled sensitivity and specificity were calculated on a per patient based analysis. Subgroup analyses considering the device used (PET versus PET/CT) and the localization of the primary tumor (intrahepatic cholangiocarcinoma (IH-CCa), extrahepatic cholangiocarcinoma (EH-CCa), and hilar cholangiocarcinoma (H-CCa)) were carried out. Results. Twenty-three studies including 1232 patients were included in the meta-analysis. Pooled sensitivity and specificity of 18F-FDG-PET or PET/CT were 81% and 82%, respectively. Pooled sensitivity and specificity, respectively, were 80% and 89% for PET, 82% and 75% for PET/CT, 95% and 83% for IH-CCa, 84% and 95% for H-CCa, and 76% and 74% for EH-CCa. Conclusions. 18F-FDG-PET and PET/CT were demonstrated to be accurate diagnostic imaging methods for primary tumor evaluation in patients with CCa. These tools have a better diagnostic accuracy in patients with IH-CCa than in patients with EH-CCa. Further studies are needed to evaluate the accuracy of 18F-FDG-PET or PET/CT in patients with H-CCa.

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“…The average SUV values for involved organs of IgG4-related disease were reported to be 4.14 (range, 0.30-8.78) (17) or 3.2 (range, 1.1-8.3) (19). In contrast, the mean SUVmax of biliary malignancy was reported to be 6.4 ± 4.6 (20). The findings of an SUVmax of 8.2 and the localized accumulation of 18 F-FDG in the present case were thought to hamper the differential diagnosis from biliary malignancy.…”

Section: Discussionmentioning

confidence: 99%

A Resected Case of Follicular Cholangitis That Was Positive on <sup>18</sup>F-fluorodeoxyglucose-positron Emission Tomography

Kosone¹,

Takagi²,

Takakusagi³

et al. 2020

Intern. Med.

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We experienced a case of follicular cholangitis that was positive on fluorodeoxyglucose-positron emission tomography (18 F-FDG-PET). A 70-year-old man was admitted for jaundice. Endoscopic retrograde cholangiography showed stenosis of the middle to upper choledocus. 18 F-FDG-PET depicted a localized hot spot at the stenotic lesion (maximum standardized uptake value = 8.2). Although no malignant findings were found in the cytology or on a bile duct biopsy, malignancy could not be excluded, so surgical treatment was performed. Follicular cholangitis is a new, rare disease that causes severe biliary stricture. Only 11 cases of follicular cholangitis have been reported, including the present case.

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Primary Tumor Maximum Standardized Uptake Value Measured on¹⁸F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Is a Prognostic Value for Survival in Bile Duct and Gallbladder Cancer

Cited by 18 publications

References 24 publications

Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

Diagnostic Accuracy of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Evaluation of the Primary Tumor in Patients with Cholangiocarcinoma: A Meta-Analysis

A Resected Case of Follicular Cholangitis That Was Positive on <sup>18</sup>F-fluorodeoxyglucose-positron Emission Tomography

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Primary Tumor Maximum Standardized Uptake Value Measured on18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Is a Prognostic Value for Survival in Bile Duct and Gallbladder Cancer

Cited by 18 publications

References 24 publications

Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

Diagnostic Accuracy of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Evaluation of the Primary Tumor in Patients with Cholangiocarcinoma: A Meta-Analysis

A Resected Case of Follicular Cholangitis That Was Positive on <sup>18</sup>F-fluorodeoxyglucose-positron Emission Tomography

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Primary Tumor Maximum Standardized Uptake Value Measured on¹⁸F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Is a Prognostic Value for Survival in Bile Duct and Gallbladder Cancer