Primary Tumor Standardized Uptake Value Measured on Fluorodeoxyglucose Positron Emission Tomography Is of Prognostic Value for Survival in Non-small Cell Lung Cancer: Update of a Systematic Review and Meta-Analysis by the European Lung Cancer Working Party for the International Association for the Study of Lung Cancer Staging Project

Paesmans, Marianne; Berghmans, Thierry; Dusart, Michelle; Garcia, C.; Hossein-Foucher, Claude; Lafitte, Jean-Jacques; Mascaux, Céline; Meert, Anne-Pascale; Roelandts, Martine; Scherpereel, Arnaud; Munoz, Vanessa Terrones; Sculier, Jean-Paul

doi:10.1097/jto.0b013e3181d0a4f5

Cited by 237 publications

(159 citation statements)

References 38 publications

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“…6) Our results show that FDG uptake measured by SUVmax is a prognostic factor in stage I lung adenocarcinoma treated with surgery, which is consistent with the results of previous studies. However, the definitions and implications of high-and low-risk PET findings have yet to be determined.…”

Section: Discussionsupporting

confidence: 93%

Prognostic Impact of FDG-PET in Surgically Treated Pathological Stage I Lung Adenocarcinoma

Higuchi

Hasegawa

Osugi

et al. 2014

ATCS

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Purpose: This retrospective study evaluated whether the maximum standardized uptake value (SUVmax) on 18F-deoxyglucose (FDG)-positron emission tomography (PET) could be used to predict the prognosis of patients with pathological stage I adenocarcinoma. Methods: We analyzed 138 consecutive patients with pathological stage IA or IB lung adenocarcinoma except pure bronchioloalveolar carcinoma (BAC) who underwent preoperative FDG-PET imaging and curative resection from January 2005 to October 2010. We analyzed associations between disease-free survival (DFS) and clinicopathological factors. Results: The 5-year DFS rate was 77.7%. Twenty two patients (15.9%) developed recurrence after surgery. Multivariate analysis identified SUVmax and lymphovascular (ly) involvement as the independent prognostic factors for recurrence (p = 0.0255 and p = 0.0333, respectively). We divided the patients into groups according to SUVmax and ly involvement. The 5-year DFS rate was 97.0% in patients with SUVmax ≤2.5 and without ly involvement, 100% with both SUVmax ≤2.5 and ly involvement, 70.2% with SUVmax >2.5 and without ly involvement, and 53.1% with both SUVmax >2.5 and ly involvement. Conclusions: The results of this study suggest that SUVmax and ly involvement could be used to predict the prognosis of patients with pathological stage I adenocarcinoma. The combination of these prognostic factors could also identify high risk groups of recurrence.

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Section: Discussionsupporting

confidence: 93%

Prognostic Impact of FDG-PET in Surgically Treated Pathological Stage I Lung Adenocarcinoma

Higuchi

Hasegawa

Osugi

et al. 2014

ATCS

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“…These cells must metabolize glucose by glycolysis, rather than oxidative phosphorylation, to prevent apoptosis, thereby increasing their glucose utilization. In turn, high levels of glucose metabolism, as inferred from 18 F-FDG PET studies, have been shown to correlate with poor outcome in patients with NSCLC (5,6).…”

Section: Discussionmentioning

confidence: 99%

“…PET with 18 F-FDG, a radiolabeled form of glucose, exploits genomic and gene alterations in malignant cells that results in alterations in glucose metabolism, an effect first described by Otto Warburg in 1924 (4). There is evidence that alterations in glucose metabolism in primary lung tumors, resulting in greater glucose utilization and hence 18 F-FDG uptake, may correlate with a more aggressive phenotype (5,6).…”

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confidence: 99%

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Sex and SUVmax: Sex-Dependent Prognostication in Early Non–Small Cell Lung Cancer

et al. 2012

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The identification of robust prognostic factors for patients with early-stage non-small cell lung cancer (NSCLC) is clinically important. The International Association for the Study of Lung Cancer has identified both sex and the maximum standardized uptake value (SUVmax) of 18 F-FDG in the primary tumor as measured by PET as potential prognostic variables. We examined the prognostic value of SUVmax in a surgical cohort of patients with NSCLC and disaggregated the findings by sex. Methods: Patients who had undergone a preoperative PET/CT scan and surgical resection with curative intent from 2001 to 2009 were identified from a prospective database. An SUVmax cutoff was calculated using receiver-operating-characteristic curves. Overall survival was correlated with SUVmax for the whole cohort and disaggregated by sex. Results: Inclusion criteria were met by 189 patients: 127 (67%) men and 62 (33%) women. Five-year survival was 54.6% for the whole cohort, 47.7% for men, and 68.2% for women. SUVmax correlated negatively with survival in a univariate analysis for the whole cohort (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.54-4.09; P , 0.001) and men (HR, 3.42; 95% CI, 1.94-6.05; P , 0.001) but not for women (HR, 1.61; 95% CI, 0.43-3.12; P 5 0.77), using 8 as a cutoff. In multivariate analysis, SUVmax correlated with overall survival for the whole cohort (HR, 1.70; 95% CI, 1.05-2.99; P 5 0.05) and men (HR, 2.40; 95% CI, 1.32-4.37; P 5 0.004) but not for women (HR, 0.80; 95% CI,; P 5 0.80). Conclusion: SUVmax independently predicted overall survival for men but not for women in this surgical cohort. Our results suggest that SUVmax is an independent prognostic variable in men with surgically treated early NSCLC.

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“…Pour la 7 e édition, les facteurs pronostiques avaient été étudiés sur la banque de données de l'IASLC. Il y avait été proposé certains facteurs résumés dans le tableau 4, qui ont un rôle pronostique important, à savoir le stade clinique, l'indice de performance, l'âge, le sexe, et, dans certains cas, le type histologique, le SUVmax à la TEP et certains paramètres biologiques [23,24]. Tout ceci devrait être revu avec des données prospectives beaucoup plus complètes qui devraient être disponibles pour la classi cation suivante.…”

Section: Pronosticunclassified

Classification TNM du cancer bronchique

Sculier

2014

Revue des Maladies Respiratoires Actualités

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RésuméLa classi cation TNM des cancers bronchiques a changé en 2009 sur la base d'une nouvelle approche méthodologique. Les différentes modi cations et le nouveau système sont décrits avec les différents descripteurs et symboles utilisés. La nouvelle carte ganglionnaire lymphatique avec ses différentes stations et zones est présentée. Les rôles pronostiques et opérationnels sont discutés ainsi que les améliorations potentielles à apporter. ©2014 SPLF. Publié par Elsevier Masson SAS. Tous droits réservés. AbstractThe TNM classi cation has changed in 2009 on the basis of a new methodological approach. The various modi cations and the new system are described with the different descriptors and symbols used. The new lymphatic nodes map is presented with the different stations and zones. The prognostic and operational roles are discussed as well as the potential improvements that might be proposed.

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Cited by 237 publications

References 38 publications

Prognostic Impact of FDG-PET in Surgically Treated Pathological Stage I Lung Adenocarcinoma

Prognostic Impact of FDG-PET in Surgically Treated Pathological Stage I Lung Adenocarcinoma

Sex and SUVmax: Sex-Dependent Prognostication in Early Non–Small Cell Lung Cancer

Classification TNM du cancer bronchique

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