Primary urethral carcinoma in females: an epidemiologic study on demographical factors, histological types, tumour stage and survival

Derksen, Joris W.; Visser, Otto; Rivière, Guy Brutel de la; Meuleman, E.J.H.; Heldeweg, Eddi A.; Lagerveld, Brunolf W.

doi:10.1007/s00345-012-0882-5

Cited by 83 publications

(66 citation statements)

References 26 publications

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“…These results are in accordance with prior studies [2,8,9] . For the multivariable analysis, we included all significant parameters from the univariate analyses that correlated with survival.…”

Section: Discussionsupporting

confidence: 83%

“…Therefore, combining all these cases into one group carries important limitations. However, population-based studies have shown that the histological subtype of urethral carcinoma does not appear to exert an impact on prognosis [1,2,8,9] . Nonetheless, it has to be acknowledged that urethral cancer is a rare disease for which therapeutic strategies still need to be better defined [12] .…”

Section: Discussionmentioning

confidence: 99%

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Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

et al. 2016

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chronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020). Conclusion: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach. © 2016 S. Karger AG, Basel Key WordsBladder cancer · Lymph node · Prognosis · Radical cystectomy · Risk factor · Survival · Urethra Abstract Introduction: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma. Methods: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence. Results: Syn-

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

et al. 2016

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“…5 The median interval from onset of symptoms to diagnosis is about 4.5 months. 1 The proximal one-third of the female urethra is lined by transitional epithelium, the distal two-thirds by stratified squamous epithelium. Accordingly, the histology of urethral tumours is generally consistent with the location.…”

Section: Discussionmentioning

confidence: 99%

“…6 Spread of urethral carcinoma also follows the anatomic subdivision: the anterior/distal female urethra drains primarily to the inguinal nodes; the mid-and proximal urethra drains to the external iliac and deep pelvic lymph nodes. 1 Female urethral carcinoma is rare, with a poor prognosis; it has a 5-and 10-year survival rate of 32% to 51% and 31% to 42%, respectively. 8 Data on this topic are limited, composed mostly of small case series.…”

Section: Discussionmentioning

confidence: 99%

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Primary proximal urethral adenocarcinoma: Case report and brief review

Siosaki

Machado

Souza

et al. 2013

CUAJ

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case report E499Cite as: Can Urol Assoc J 2013;7(7-8):e499-501. http://dx.doi.org/10.5489/cuaj.399 Published online July 2, 2013. AbstractPrimary urethral cancer in females is rare. It has a poor prognosis. The published data on this topic are limited, composed mostly of small case series. This paper presents a case of an advanced adenocarcinoma of the urethra, intestinal type, treated with anterior exenteration.

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Clinical features and oncological outcomes of primary female urethral cancer

Lee

et al. 2022

Journal of Surgical Oncology

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Investigation of the clinical features and treatment outcomes of primary female urethral cancer (FUC) at a single institution. Materials and Methods: We retrospectively reviewed 32 FUC patients during 1997-2017. We investigated preoperative risk factors predicting overall (overall survival [OS]) and recurrence-free survival (RFS) and reviewed clinical features, treatment modality, and oncologic outcomes according to pathology. The median follow-up duration and age was 56 months (range: 4-229) and 61 years (range: 15-82), respectively.Results: The median OS and RFS were 70 and 16 months, respectively. A total of 19 (59.4%) patients received systemic chemotherapy, including 14 (43.8%) who received radiation therapy. Further, 22 patients (68.8%) underwent surgery. On univariate analysis, >T2, N+, and tumor size ≥3 cm were associated with poorer OS. There were 15 cases of distant metastasis and five local recurrences.Outcomes were poorest in adenocarcinoma (AC), moderate in clear cell carcinoma and transitional cell carcinoma, and best in squamous cell carcinoma (SCC). Conclusion:Female urethral lesions should be carefully examined to exclude FUC.Distal urethral SCC was responsive to surgical excision, but proximal urethral AC had poor oncological outcome even after extensive treatment. Due to the heterogeneity and poor prognosis of FUC, multimodal treatment is mandatory.

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Primary urethral carcinoma in females: an epidemiologic study on demographical factors, histological types, tumour stage and survival

Cited by 83 publications

References 26 publications

Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

Primary proximal urethral adenocarcinoma: Case report and brief review

Clinical features and oncological outcomes of primary female urethral cancer

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