Primary uterine rhabdomyosarcoma in a patient with a history of breast cancer and gastrointestinal stromal tumor

Gottwald, Leszek; Góra, Ewa; Korczyński, Jerzy; Piekarski, Janusz; Morawiec, Zbigniew; Jesionek-Kupnicka, Dorota; Sowa, Piotr; Ciałkowska-Rysz, Aleksandra; Bieńkiewicz, Andrzej

doi:10.1111/j.1447-0756.2008.00915.x

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Gottwald et al 35 reported the development of a uterine rhabdomyosarcoma in a patient currently treated with Anastrozole. The authors question whether there is an association of uterine pathology with the use of AIs.…”

Section: Other Sarcomasmentioning

confidence: 99%

Uterine Sarcoma and Aromatase Inhibitors: Tom Baker Cancer Centre Experience and Review of the Literature

Altman

Nelson

Chu

et al. 2012

Int J Gynecol Cancer

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Section: Other Sarcomasmentioning

confidence: 99%

Uterine Sarcoma and Aromatase Inhibitors: Tom Baker Cancer Centre Experience and Review of the Literature

Altman

Nelson

Chu

et al. 2012

Int J Gynecol Cancer

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“…To the best of our knowledge, besides the present case, only Gottwald et al, in 2008, reported such case. They reported that she had previous history of breast carcinoma, and interestingly, was diagnosed with both uterine RMS and Gastric GIST while receiving adjuvant hormonal therapy for breast cancer [ 30 ]. The present case had no past medical history, yet pursued a very aggressive clinical course and died 3 months after surgery because of complications of systemic metastasis,despite receiving postoperative chemotherapy and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

A rare adult case of primary uterine rhabdomyosarcoma with mixed pattern: a clinicopathological & immunohistochemical study with literature review

Kamel,

Hasby

2024

Diagn Pathol

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Background Rhabdomyosarcomas are aggressive tumors that comprise a group of morphologically similar but biologically diverse lesions. Owing to its rarity, Mixed pattern RMS (ARMS and ERMS) constitutes a diagnostic and therapeutic dilemma. Case Herein is presented a very rare case of mixed alveolar & embryonal rhabdomyosarcoma in the uterus of a 68-year-old woman. The wall of the uterine corpus & cervix was replaced by multiple whitish–yellow, firm nodules, measuring up to 12 cm. Microscopically, the tumor was predominantly composed of round to polygonal cells arranged in nests with alveolar pattern intermingled with hypo- & hypercellular areas of more primitive cells with scattered multinucleated giant cells seen as well. Extensive sampling failed to show epithelial elements. Immunohistochemical staining showed positive staining for vimentin, desmin, myogenin, CD56 & WT-1. However, no staining was detected for CK, LCA, CD10, ER, SMA, CD99, S100, Cyclin-D1 & Olig-2. Metastatic deposits were found in the peritoneum. The patient received postoperative chemotherapy and radiotherapy but died of systemic metastases 3 months after surgery. Conclusion The rarity of this histological tumor entity and its aggressive behavior and poor prognosis grab attention to improving recognition and treatment modalities in adults.

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“…4 Uterine rhabdomyosarcomas have been reported in patients treated with either tamoxifen citrate or anastrozole for breast carcinoma. 5,6 Although a causative effect cannot be elicited, it is interesting that such a rare tumor as rhabdomyosarcoma in adults has been associated with patients previously treated with anastrozole or tamoxifen for breast cancer. However, the role of these medications in the development of rhabdomyosarcoma is purely speculative and requires further investigation before a pathogenic effect can be proposed.…”

Section: Commentmentioning

confidence: 99%

Caruncular Alveolar Rhabdomyosarcoma in a Woman Previously Treated for Breast Cancer

Ramstead¹,

Buffam²,

White³

2012

Arch Ophthalmol

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Accelerated development of conjunctival melanoma during pregnancy may be simply coincidence. This has been postulated for cutaneous melanoma, although most studies suggest a genuine increased risk. 4 The 2 main postulated theories for this increased risk are hormonal factors and decreased immunity. Several investigators have examined the role of sex hormone receptor status in conjunctival melanoma, PAM, and nevi. 3,5,6 Chowers et al 5 investigated 2 cases of conjunctival melanoma and 13 cases of PAM and were unable to detect estrogen receptors in any. Paridaens et al 3 found that 6 of 15 conjunctival melanomas were estrogen receptor positive. More recently, Pache et al 6 found expression of progesterone receptors in 96% of cases, consisting of 69 nevi, 5 cases of PAM, and 2 melanomas. Staining for estrogen and progesterone receptors was negative in this patient. Changes in immunity that accompany pregnancy may also play an important role. To protect the fetus from rejection, pregnancy induces immunosuppression with a predominant T-helper 2 response to inciting stimuli. Indeed, the severity of many diseases has been shown to be affected by pregnancy. This anti-inflammatory response may also affect tumor surveillance and promote tumor growth. This reduction in immune surveillance has been suggested by Paridaens et al, 3 who described a young woman with growth of conjunctival melanosis and melanoma during the course of 3 pregnancies. An additional feature of concern in this patient was that the PAM was nonpigmented in some areas. While PAM sine pigmento is well recognized, often in conjunction with pigmented areas, it can be difficult to follow up. 7 In conclusion, while this link with pregnancy and conjunctival melanoma progression cannot be fully explained, it would be prudent for young women with PAM with atypia to be closely monitored during reproductive life.

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Primary uterine rhabdomyosarcoma in a patient with a history of breast cancer and gastrointestinal stromal tumor

Cited by 6 publications

References 15 publications

Uterine Sarcoma and Aromatase Inhibitors: Tom Baker Cancer Centre Experience and Review of the Literature

Uterine Sarcoma and Aromatase Inhibitors: Tom Baker Cancer Centre Experience and Review of the Literature

A rare adult case of primary uterine rhabdomyosarcoma with mixed pattern: a clinicopathological & immunohistochemical study with literature review

Caruncular Alveolar Rhabdomyosarcoma in a Woman Previously Treated for Breast Cancer

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